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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946).
ChemMedChem. 2016 Jul 19;11(14):1517-30. doi: 10.1002/cmdc.201600148. Epub 2016 Jun 16.
ChemMedChem. 2016.
PMID: 27310202
Free PMC article.
BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models.
Liu N, Rowley BR, Bull CO, Schneider C, Haegebarth A, Schatz CA, Fracasso PR, Wilkie DP, Hentemann M, Wilhelm SM, Scott WJ, Mumberg D, Ziegelbauer K.
Liu N, et al. Among authors: bull co.
Mol Cancer Ther. 2013 Nov;12(11):2319-30. doi: 10.1158/1535-7163.MCT-12-0993-T. Epub 2013 Oct 29.
Mol Cancer Ther. 2013.
PMID: 24170767
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Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.
Lapierre JM, Eathiraj S, Vensel D, Liu Y, Bull CO, Cornell-Kennon S, Iimura S, Kelleher EW, Kizer DE, Koerner S, Makhija S, Matsuda A, Moussa M, Namdev N, Savage RE, Szwaya J, Volckova E, Westlund N, Wu H, Schwartz B.
Lapierre JM, et al. Among authors: bull co.
J Med Chem. 2016 Jul 14;59(13):6455-69. doi: 10.1021/acs.jmedchem.6b00619. Epub 2016 Jun 29.
J Med Chem. 2016.
PMID: 27305487
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Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.
Ashwell MA, Lapierre JM, Brassard C, Bresciano K, Bull C, Cornell-Kennon S, Eathiraj S, France DS, Hall T, Hill J, Kelleher E, Khanapurkar S, Kizer D, Koerner S, Link J, Liu Y, Makhija S, Moussa M, Namdev N, Nguyen K, Nicewonger R, Palma R, Szwaya J, Tandon M, Uppalapati U, Vensel D, Volak LP, Volckova E, Westlund N, Wu H, Yang RY, Chan TC.
Ashwell MA, et al.
J Med Chem. 2012 Jun 14;55(11):5291-310. doi: 10.1021/jm300276x. Epub 2012 May 31.
J Med Chem. 2012.
PMID: 22533986
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Recurrent genital infection in the guinea pig: differences between herpes simplex types 1 and 2.
Landry ML, Myerson D, Bull C.
Landry ML, et al.
Intervirology. 1992;34(4):169-79. doi: 10.1159/000150279.
Intervirology. 1992.
PMID: 1339184
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Herpes simplex types 1 and 2: latency in the genital tract of guinea pigs.
Landry ML, Bull C.
Landry ML, et al.
Intervirology. 1992;33(4):204-10. doi: 10.1159/000150252.
Intervirology. 1992.
PMID: 1326498
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Antiviral activity of 5-iodo-2'-deoxyuridine and related drugs in human keratinocytes infected in vitro with herpes simplex virus type 1.
Reuveni H, Bull CO, Landry ML, Milstone LM, Schwartz PM.
Reuveni H, et al. Among authors: bull co.
Skin Pharmacol. 1991;4(4):291-7. doi: 10.1159/000210964.
Skin Pharmacol. 1991.
PMID: 1665069
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Identification of functional domains in murine granulocyte-macrophage colony-stimulating factor using monoclonal antibodies to synthetic peptides.
Greenfield RS, Braslawsky GR, Kadow KF, Spitalny GL, Chace D, Bull CO, Bursuker I.
Greenfield RS, et al. Among authors: bull co.
J Immunol. 1993 Jun 15;150(12):5241-51.
J Immunol. 1993.
PMID: 8515057
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