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94 results
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Rescuing the function of mutant p53.
Bullock AN, Fersht AR. Bullock AN, et al. Nat Rev Cancer. 2001 Oct;1(1):68-76. doi: 10.1038/35094077. Nat Rev Cancer. 2001. PMID: 11900253 Review.
Thermodynamic stability of wild-type and mutant p53 core domain.
Bullock AN, Henckel J, DeDecker BS, Johnson CM, Nikolova PV, Proctor MR, Lane DP, Fersht AR. Bullock AN, et al. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14338-42. doi: 10.1073/pnas.94.26.14338. Proc Natl Acad Sci U S A. 1997. PMID: 9405613 Free PMC article.
CIS is a potent checkpoint in NK cell-mediated tumor immunity.
Delconte RB, Kolesnik TB, Dagley LF, Rautela J, Shi W, Putz EM, Stannard K, Zhang JG, Teh C, Firth M, Ushiki T, Andoniou CE, Degli-Esposti MA, Sharp PP, Sanvitale CE, Infusini G, Liau NP, Linossi EM, Burns CJ, Carotta S, Gray DH, Seillet C, Hutchinson DS, Belz GT, Webb AI, Alexander WS, Li SS, Bullock AN, Babon JJ, Smyth MJ, Nicholson SE, Huntington ND. Delconte RB, et al. Among authors: bullock an. Nat Immunol. 2016 Jul;17(7):816-24. doi: 10.1038/ni.3470. Epub 2016 May 23. Nat Immunol. 2016. PMID: 27213690
Computational redesign of protein-protein interaction specificity.
Kortemme T, Joachimiak LA, Bullock AN, Schuler AD, Stoddard BL, Baker D. Kortemme T, et al. Among authors: bullock an. Nat Struct Mol Biol. 2004 Apr;11(4):371-9. doi: 10.1038/nsmb749. Epub 2004 Mar 21. Nat Struct Mol Biol. 2004. PMID: 15034550
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.
Taylor KR, Mackay A, Truffaux N, Butterfield Y, Morozova O, Philippe C, Castel D, Grasso CS, Vinci M, Carvalho D, Carcaboso AM, de Torres C, Cruz O, Mora J, Entz-Werle N, Ingram WJ, Monje M, Hargrave D, Bullock AN, Puget S, Yip S, Jones C, Grill J. Taylor KR, et al. Among authors: bullock an. Nat Genet. 2014 May;46(5):457-461. doi: 10.1038/ng.2925. Epub 2014 Apr 6. Nat Genet. 2014. PMID: 24705252 Free PMC article.
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, Geyer M, Bullock AN, Young RA, Gray NS. Zhang T, et al. Among authors: bullock an. Nat Chem Biol. 2016 Oct;12(10):876-84. doi: 10.1038/nchembio.2166. Epub 2016 Aug 29. Nat Chem Biol. 2016. PMID: 27571479 Free PMC article.
Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.
Linossi EM, Chandrashekaran IR, Kolesnik TB, Murphy JM, Webb AI, Willson TA, Kedzierski L, Bullock AN, Babon JJ, Norton RS, Nicola NA, Nicholson SE. Linossi EM, et al. Among authors: bullock an. PLoS One. 2013 Aug 21;8(8):e70536. doi: 10.1371/journal.pone.0070536. eCollection 2013. PLoS One. 2013. PMID: 23990909 Free PMC article.
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Shintre CA, Pike AC, Li Q, Kim JI, Barr AJ, Goubin S, Shrestha L, Yang J, Berridge G, Ross J, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, Marsden BD, von Delft F, Bullock AN, Gileadi O, Burgess-Brown NA, Carpenter EP. Shintre CA, et al. Among authors: bullock an. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9710-5. doi: 10.1073/pnas.1217042110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716676 Free PMC article.
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