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Failure to detect preterm infants at risk of hypoglycemia before discharge.
Hume R, McGeechan A, Burchell A. Hume R, et al. J Pediatr. 1999 Apr;134(4):499-502. doi: 10.1016/s0022-3476(99)70210-6. J Pediatr. 1999. PMID: 10190927 Clinical Trial.
In a series of 79 consecutive preterm infants who were ready for discharge, 14 (18%) infants were unable to maintain normal concentrations of blood glucose. This finding suggests that a significant number of preterm infants are at risk of hypoglycemia at home if …
In a series of 79 consecutive preterm infants who were ready for discharge, 14 (18%) infants were unable to maintain normal concentra …
Identification of novel polymorphisms in the glucokinase and glucose-6-phosphatase genes in infants who died suddenly and unexpectedly.
Forsyth L, Hume R, Howatson A, Busuttil A, Burchell A. Forsyth L, et al. J Mol Med (Berl). 2005 Aug;83(8):610-8. doi: 10.1007/s00109-005-0666-0. Epub 2005 May 26. J Mol Med (Berl). 2005. PMID: 15918042
A novel heterozygous polymorphism -77G>A in the G6PC1 promoter in 6.3% of non-SIDS and 2.9% of control infants decreased basal G6PC1 promoter activity (p<0.001). We describe three novel polymorphisms in the GK gene, S263S, -45G>A, and a common
A novel heterozygous polymorphism -77G>A in the G6PC1 promoter in 6.3% of non-SIDS and 2.9% of control infants decreased ba
Plasma catecholamines and the counterregulatory responses to hypoglycemia in infants: a critical role for epinephrine and cortisol.
Jackson L, Williams FL, Burchell A, Coughtrie MW, Hume R. Jackson L, et al. J Clin Endocrinol Metab. 2004 Dec;89(12):6251-6. doi: 10.1210/jc.2004-0550. J Clin Endocrinol Metab. 2004. PMID: 15579785
The purpose of this study was to define plasma catecholamine responses as part of the counterregulatory hormonal reaction to hypoglycemia in infants after a regular 3- to 4-h feed was omitted. ...
The purpose of this study was to define plasma catecholamine responses as part of the counterregulatory hormonal reaction to hypoglycemia in …
Glucose homeostasis in the newborn.
Hume R, Burchell A, Williams FL, Koh DK. Hume R, et al. Early Hum Dev. 2005 Jan;81(1):95-101. doi: 10.1016/j.earlhumdev.2004.10.005. Epub 2004 Nov 19. Early Hum Dev. 2005. PMID: 15707720 Review.
Firstly, up to 20% of preterm infants about to be discharged home are at risk of hypoglycaemia if a feed is delayed. Cortisol, corticotrophin and epinephrine levels are higher in the infants with severe and persistent hypoglycaemia, but insulin, glucagon and human growth h …
Firstly, up to 20% of preterm infants about to be discharged home are at risk of hypoglycaemia if a feed is delayed. Cortisol, cortic …
Developmental disorders of glucose metabolism in infants.
Hume R, McGeechan A, Burchell A. Hume R, et al. Child Care Health Dev. 2002 Sep;28 Suppl 1:45-7. doi: 10.1046/j.1365-2214.2002.00013.x. Child Care Health Dev. 2002. PMID: 12515440
The standard method of functionally measuring hepatic glucose production and/or disordered glucose production is the response to a glucagon tolerance test. ...CONCLUSIONS: An increase in plasma glucose of less than 4 mmol/L is considered abnormal in adults following admini …
The standard method of functionally measuring hepatic glucose production and/or disordered glucose production is the response to a gl …
Polymorphisms in genes involved in glucose metabolism in cases of sudden infant death syndrome.
Burchell A, Forsyth L, Hume R. Burchell A, et al. Child Care Health Dev. 2002 Sep;28 Suppl 1:37-9. doi: 10.1046/j.1365-2214.2002.00011.x. Child Care Health Dev. 2002. PMID: 12515438
A number of mutations in key proteins involved in regulation of blood glucose (e.g. glucokinase) have been found to result in reduced birth weight. ...This clearly shows that while MODY babies are often small, MODY is not a common cause of either intra-uterine growt
A number of mutations in key proteins involved in regulation of blood glucose (e.g. glucokinase) have been found to result in reduced
Perinatal factors influencing hepatic glucose-6-phosphatase enzyme activity.
Hume R, McGeechan A, Burchell A. Hume R, et al. J Perinatol. 2000 Jul-Aug;20(5):301-6. doi: 10.1038/sj.jp.7200379. J Perinatol. 2000. PMID: 10920788
STUDY DESIGN: The maximum velocity (Vmax) of the hepatic microsomal glucose-6-phosphatase enzyme, as the dependent variable, was correlated by stepwise multiple regression analysis with clinical data from a consecutive series of 45 preterm infants from a level 3 neo …
STUDY DESIGN: The maximum velocity (Vmax) of the hepatic microsomal glucose-6-phosphatase enzyme, as the dependent variable, was correlated …
The glucose-6-phosphatase enzyme in developing human trachea and oesophagus.
Hume R, Burchell A. Hume R, et al. Histochem J. 1996 Feb;28(2):141-7. doi: 10.1007/BF02331419. Histochem J. 1996. PMID: 8737295
Recently, it has become clear that it is also present in lower amounts in a variety of other tissues. Previous histochemical studies of glucose-6-phosphate hydrolysis in trachea have given equivocal results and only one study on adult oesophagus has shown glucose-6-phospha …
Recently, it has become clear that it is also present in lower amounts in a variety of other tissues. Previous histochemical studies …
Abnormal expression of glucose-6-phosphatase in preterm infants.
Hume R, Burchell A. Hume R, et al. Arch Dis Child. 1993 Feb;68(2):202-4. doi: 10.1136/adc.68.2.202. Arch Dis Child. 1993. PMID: 8386919 Free PMC article.
Early detection of metabolic abnormalities in preterm infants impaired by disorders of blood glucose concentrations.
Lyall H, Burchell A, Howie PW, Ogston S, Hume R. Lyall H, et al. Clin Chem. 1994 Apr;40(4):526-30. Clin Chem. 1994. PMID: 8149605

We have therefore studied retrospectively in a matched cohort of 109 infants the blood glucose profiles correlated with the severity of respiratory distress syndrome (expressed as the fraction of inspired oxygen, FiO2): group A, mild, FiO2 < 0.25; group B, modera

We have therefore studied retrospectively in a matched cohort of 109 infants the blood glucose profiles correlated with the severity …
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