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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.
Moskal JR, Burch R, Burgdorf JS, Kroes RA, Stanton PK, Disterhoft JF, Leander JD. Moskal JR, et al. Among authors: burgdorf js. Expert Opin Investig Drugs. 2014 Feb;23(2):243-54. doi: 10.1517/13543784.2014.852536. Epub 2013 Nov 20. Expert Opin Investig Drugs. 2014. PMID: 24251380 Free PMC article. Review.
Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.
Burgdorf J, Kroes RA, Zhang XL, Gross AL, Schmidt M, Weiss C, Disterhoft JF, Burch RM, Stanton PK, Moskal JR. Burgdorf J, et al. Behav Brain Res. 2015 Nov 1;294:177-85. doi: 10.1016/j.bbr.2015.07.039. Epub 2015 Jul 22. Behav Brain Res. 2015. PMID: 26210936 Free PMC article.
Social, communication, and cortical structural impairments in Epac2-deficient mice.
Srivastava DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Moskal JR, Casanova MF, Waters J, Penzes P. Srivastava DP, et al. Among authors: burgdorf j. J Neurosci. 2012 Aug 22;32(34):11864-78. doi: 10.1523/JNEUROSCI.1349-12.2012. J Neurosci. 2012. PMID: 22915127 Free PMC article.
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