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Are the decreases in hepatic cytochrome P-450 and other drug-metabolising enzymes caused by indomethacin in vivo mediated by intestinal bacterial endotoxins? 16,16-Dimethylprostaglandin F2 alpha prevents decreases in hepatic drug-metabolising enzymes due to exogenous endotoxin.
Falzon M, Milton AS, Burke MD. Falzon M, et al. Among authors: burke md. Biochem Pharmacol. 1984 Apr 15;33(8):1285-92. doi: 10.1016/0006-2952(84)90182-5. Biochem Pharmacol. 1984. PMID: 6370266
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