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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ. Curtain CC, et al. Among authors: bush ai. J Biol Chem. 2001 Jun 8;276(23):20466-73. doi: 10.1074/jbc.M100175200. Epub 2001 Mar 27. J Biol Chem. 2001. PMID: 11274207 Free article.
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI. Cherny RA, et al. Among authors: bush ai. Neuron. 2001 Jun;30(3):665-76. doi: 10.1016/s0896-6273(01)00317-8. Neuron. 2001. PMID: 11430801 Free article.
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R. Barnham KJ, et al. Among authors: bush ai. J Biol Chem. 2003 Oct 31;278(44):42959-65. doi: 10.1074/jbc.M305494200. Epub 2003 Aug 18. J Biol Chem. 2003. PMID: 12925530 Free article.
Neurodegenerative diseases and oxidative stress.
Barnham KJ, Masters CL, Bush AI. Barnham KJ, et al. Among authors: bush ai. Nat Rev Drug Discov. 2004 Mar;3(3):205-14. doi: 10.1038/nrd1330. Nat Rev Drug Discov. 2004. PMID: 15031734 Review.
489 results