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121 results

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Page 1
Buspirone.
Wilson TK, Tripp J. Wilson TK, et al. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30285372 Free Books & Documents.
Buspirone has recently come into favor, primarily due to its decreased side-effect profile compared to other anxiolytic treatments. ...Off-labeled buspirone is used for the augmentation of unipolar depression. This activity reviews the mechanism of action, adverse e …
Buspirone has recently come into favor, primarily due to its decreased side-effect profile compared to other anxiolytic treatments. . …
The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease.
Thomas Broome S, Castorina A. Thomas Broome S, et al. Int J Mol Sci. 2022 Feb 6;23(3):1845. doi: 10.3390/ijms23031845. Int J Mol Sci. 2022. PMID: 35163768 Free PMC article.
We found that high dosages of buspirone prevented the behavioural deficits caused by rotenone in the open field test. ...These results pinpoint the neuroprotective efficacy of buspirone against rotenone toxicity, suggesting its potential use as a therapeutic …
We found that high dosages of buspirone prevented the behavioural deficits caused by rotenone in the open field test. ...These result …
Buspirone attenuated methotrexate-induced hippocampal toxicity in rats by regulating Nrf2/HO-1, PPAR-gamma, NF-kappaB/nNOS, and ROS/NLRP3/caspase-1 signaling pathways.
Althagafy HS, Sharawi ZW, Batawi AH, Almohaimeed HM, Al-Thubiani WS, Hassanein EHM, Rateb A. Althagafy HS, et al. J Biochem Mol Toxicol. 2023 Sep;37(9):e23414. doi: 10.1002/jbt.23414. Epub 2023 Jun 21. J Biochem Mol Toxicol. 2023. PMID: 37341015
Proinflammatory cytokine production and oxidative stress are possible mechanisms for MTX-induced neurotoxicity. Buspirone (BSP), a partial agonist of the 5-HT1a receptor (5-HT1aR), has emerged as an anxiolytic drug. ...The current study investigated BSP's potential anti-in …
Proinflammatory cytokine production and oxidative stress are possible mechanisms for MTX-induced neurotoxicity. Buspirone (BSP), a pa …
Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium.
Biswal MR, Paulson RJ, Vichare R, Lewin AS. Biswal MR, et al. Antioxidants (Basel). 2023 Dec 17;12(12):2129. doi: 10.3390/antiox12122129. Antioxidants (Basel). 2023. PMID: 38136248 Free PMC article.
We exposed differentiated human ARPE-19 cells to paraquat to induce oxidative damage in culture, and utilized a mouse model with sodium iodate (NaIO(3))-induced oxidative injury to evaluate the effect of buspirone. To investigate buspirone's effect on protect …
We exposed differentiated human ARPE-19 cells to paraquat to induce oxidative damage in culture, and utilized a mouse model with sodium ioda …
Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model.
Salimi A, Razian M, Pourahmad J. Salimi A, et al. Curr Clin Pharmacol. 2018;13(2):120-127. doi: 10.2174/1574884713666180516112920. Curr Clin Pharmacol. 2018. PMID: 29766823
RESULTS: Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 g/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide …
RESULTS: Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 g/ml, af …
Buspirone: a new type of anxiolytic.
Dommisse CS, DeVane CL. Dommisse CS, et al. Drug Intell Clin Pharm. 1985 Sep;19(9):624-8. doi: 10.1177/106002808501900903. Drug Intell Clin Pharm. 1985. PMID: 2864225 Review.
Buspirone is a member of a new class of agents known as azaspirodecanediones, and represents the first nonbenzodiazepine anxiolytic to be introduced in the U.S. in recent years. ...The drug is reported to have minimal sedating effect, to cause no impairment of driving-rela …
Buspirone is a member of a new class of agents known as azaspirodecanediones, and represents the first nonbenzodiazepine anxiolytic t …
Antidepressant- and anxiolytic-like activities and acute toxicity evaluation of the Psilocybe cubensis mushroom in experimental models in mice.
Hernandez-Leon A, Escamilla-Orozco RI, Tabal-Robles AR, Martínez-Vargas D, Romero-Bautista L, Escamilla-Soto G, González-Romero OS, Torres-Valencia M, González-Trujano ME. Hernandez-Leon A, et al. J Ethnopharmacol. 2024 Feb 10;320:117415. doi: 10.1016/j.jep.2023.117415. Epub 2023 Nov 15. J Ethnopharmacol. 2024. PMID: 37977425
AIM OF THE STUDY: To evaluate the anxiolytic- and antidepressant-like effects, as well as the acute toxicity of P. cubensis mushroom. MATERIAL AND METHODS: First, the acute toxicity (LD(50)) of P. cubensis (2000 mg/kg) was determined after the esophageal (p.o.) and …
AIM OF THE STUDY: To evaluate the anxiolytic- and antidepressant-like effects, as well as the acute toxicity of P. cubensis mushroom. …
Thermoregulatory defense mechanisms.
Sessler DI. Sessler DI. Crit Care Med. 2009 Jul;37(7 Suppl):S203-10. doi: 10.1097/CCM.0b013e3181aa5568. Crit Care Med. 2009. PMID: 19535948 Review.
Meperidine-especially in combination with buspirone-is especially effective while provoking only modest toxicity. The combination of buspirone and dexmedetomidine is comparably effective while avoiding the respiratory depression association with opioid admini …
Meperidine-especially in combination with buspirone-is especially effective while provoking only modest toxicity. The combinat …
Gepirone. Organon.
Leslie RA. Leslie RA. Curr Opin Investig Drugs. 2001 Aug;2(8):1120-7. Curr Opin Investig Drugs. 2001. PMID: 11892924 Review.
Mechanism of action studies have demonstrated that gepirone, compared to buspirone, possesses a much greater selectivity for 5-HT1A receptors over dopamine D2 receptors. ...
Mechanism of action studies have demonstrated that gepirone, compared to buspirone, possesses a much greater selectivity for 5-HT1A r …
Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo.
Zhang BW, Pang NH, Xu RA, Qu GE, Tang CR. Zhang BW, et al. Drug Des Devel Ther. 2022 Jun 30;16:2031-2042. doi: 10.2147/DDDT.S359451. eCollection 2022. Drug Des Devel Ther. 2022. PMID: 35795848 Free PMC article.
CONCLUSION: Axitinib inhibited buspirone metabolism in vivo and in vitro, which increases the risk of the side effects of buspirone in the clinic. When coadministered with axitinib, a lower dosage of buspirone should be defined to avoid a toxic respons …
CONCLUSION: Axitinib inhibited buspirone metabolism in vivo and in vitro, which increases the risk of the side effects of buspiron …
121 results