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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G. Hudson BD, et al. Among authors: butcher aj. Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26. Mol Pharmacol. 2013. PMID: 23979972 Free PMC article.
Examining site-specific GPCR phosphorylation.
Butcher AJ, Tobin AB, Kong KC. Butcher AJ, et al. Methods Mol Biol. 2011;746:237-49. doi: 10.1007/978-1-61779-126-0_12. Methods Mol Biol. 2011. PMID: 21607860
Chemogenetics defines receptor-mediated functions of short chain free fatty acids.
Bolognini D, Barki N, Butcher AJ, Hudson BD, Sergeev E, Molloy C, Moss CE, Bradley SJ, Le Gouill C, Bouvier M, Tobin AB, Milligan G. Bolognini D, et al. Among authors: butcher aj. Nat Chem Biol. 2019 May;15(5):489-498. doi: 10.1038/s41589-019-0270-1. Epub 2019 Apr 15. Nat Chem Biol. 2019. PMID: 30992568
39 results