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Big data opens a window onto wellness.
Butte AJ. Butte AJ. Nat Biotechnol. 2017 Aug 8;35(8):720-721. doi: 10.1038/nbt.3934. Nat Biotechnol. 2017. PMID: 28787419 Free PMC article. No abstract available.
Creation and implications of a phenome-genome network.
Butte AJ, Kohane IS. Butte AJ, et al. Nat Biotechnol. 2006 Jan;24(1):55-62. doi: 10.1038/nbt1150. Nat Biotechnol. 2006. PMID: 16404398 Free PMC article.
Cell type-specific gene expression differences in complex tissues.
Shen-Orr SS, Tibshirani R, Khatri P, Bodian DL, Staedtler F, Perry NM, Hastie T, Sarwal MM, Davis MM, Butte AJ. Shen-Orr SS, et al. Nat Methods. 2010 Apr;7(4):287-9. doi: 10.1038/nmeth.1439. Epub 2010 Mar 7. Nat Methods. 2010. PMID: 20208531 Free PMC article.
In silico research in the era of cloud computing.
Dudley JT, Butte AJ. Dudley JT, et al. Nat Biotechnol. 2010 Nov;28(11):1181-5. doi: 10.1038/nbt1110-1181. Nat Biotechnol. 2010. PMID: 21057489 Free PMC article. No abstract available.
Performance comparison of whole-genome sequencing platforms.
Lam HY, Clark MJ, Chen R, Chen R, Natsoulis G, O'Huallachain M, Dewey FE, Habegger L, Ashley EA, Gerstein MB, Butte AJ, Ji HP, Snyder M. Lam HY, et al. Nat Biotechnol. 2011 Dec 18;30(1):78-82. doi: 10.1038/nbt.2065. Nat Biotechnol. 2011. PMID: 22178993 Free PMC article.
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O. Mazur PK, et al. Nature. 2014 Jun 12;510(7504):283-7. doi: 10.1038/nature13320. Epub 2014 May 21. Nature. 2014. PMID: 24847881 Free PMC article.
Systematic pan-cancer analysis of tumour purity.
Aran D, Sirota M, Butte AJ. Aran D, et al. Nat Commun. 2015 Dec 4;6:8971. doi: 10.1038/ncomms9971. Nat Commun. 2015. PMID: 26634437 Free PMC article.
Leveraging big data to transform target selection and drug discovery.
Chen B, Butte AJ. Chen B, et al. Clin Pharmacol Ther. 2016 Mar;99(3):285-97. doi: 10.1002/cpt.318. Clin Pharmacol Ther. 2016. PMID: 26659699 Free PMC article. Review.
ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system.
Hughey JJ, Hastie T, Butte AJ. Hughey JJ, et al. Nucleic Acids Res. 2016 May 5;44(8):e80. doi: 10.1093/nar/gkw030. Epub 2016 Jan 26. Nucleic Acids Res. 2016. PMID: 26819407 Free PMC article.
Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses.
Paik H, Chen B, Sirota M, Hadley D, Butte AJ. Paik H, et al. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):599-607. doi: 10.1002/psp4.12108. Epub 2016 Nov 14. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27860440 Free PMC article.
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