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Page 1
Butyrate improves insulin sensitivity and increases energy expenditure in mice.
Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. Gao Z, et al. Diabetes. 2009 Jul;58(7):1509-17. doi: 10.2337/db08-1637. Epub 2009 Apr 14. Diabetes. 2009. PMID: 19366864 Free PMC article.
AMP kinase and p38 activities were elevated. In the obese mice, supplementation of butyrate led to an increase in insulin sensitivity and a reduction in adiposity. CONCLUSIONS: Dietary supplementation of butyrate can prevent and treat die …
AMP kinase and p38 activities were elevated. In the obese mice, supplementation of butyrate led to an increase in in …
Hexanoic Acid Improves Metabolic Health in Mice Fed High-Fat Diet.
Ikeda T, Takii K, Omichi Y, Nishimoto Y, Ichikawa D, Matsunaga T, Kawauchi A, Kimura I. Ikeda T, et al. Nutrients. 2025 Sep 4;17(17):2868. doi: 10.3390/nu17172868. Nutrients. 2025. PMID: 40944255 Free PMC article.
Free fatty acids (FFAs) serve as signaling molecules in many biological processes, leading to increased energy expenditure and insulin secretion. Short-chain fatty acids (SCFAs) such as acetic, propionic and butyric acid are bioactive metabolite …
Free fatty acids (FFAs) serve as signaling molecules in many biological processes, leading to increased energy expenditure …
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Liepinsh E, Makrecka-Kuka M, Makarova E, Volska K, Svalbe B, Sevostjanovs E, Grinberga S, Kuka J, Dambrova M. Liepinsh E, et al. Pharmacol Res. 2016 Nov;113(Pt B):788-795. doi: 10.1016/j.phrs.2015.11.014. Epub 2015 Nov 24. Pharmacol Res. 2016. PMID: 26621248
The aim of this study was to test whether exercise combined with decreasing the content of long-chain acylcarnitines represents an effective strategy to improve insulin sensitivity in diabetes. We used a novel compound, 4-[ethyl(dimethyl)ammonio]butanoate (me …
The aim of this study was to test whether exercise combined with decreasing the content of long-chain acylcarnitines represents an effective …
Butyrate Regulates Liver Mitochondrial Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice.
Mollica MP, Mattace Raso G, Cavaliere G, Trinchese G, De Filippo C, Aceto S, Prisco M, Pirozzi C, Di Guida F, Lama A, Crispino M, Tronino D, Di Vaio P, Berni Canani R, Calignano A, Meli R. Mollica MP, et al. Diabetes. 2017 May;66(5):1405-1418. doi: 10.2337/db16-0924. Epub 2017 Feb 21. Diabetes. 2017. PMID: 28223285
Here, hepatic mitochondria were identified as the main target of the beneficial effect of both butyrate-based compounds in reverting insulin resistance and fat accumulation in diet-induced obese mice. ...Finally, the shift of the mitochondrial dynamic …
Here, hepatic mitochondria were identified as the main target of the beneficial effect of both butyrate-based compounds in reverting …
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice.
Udayappan S, Manneras-Holm L, Chaplin-Scott A, Belzer C, Herrema H, Dallinga-Thie GM, Duncan SH, Stroes ESG, Groen AK, Flint HJ, Backhed F, de Vos WM, Nieuwdorp M. Udayappan S, et al. NPJ Biofilms Microbiomes. 2016 Jul 6;2:16009. doi: 10.1038/npjbiofilms.2016.9. eCollection 2016. NPJ Biofilms Microbiomes. 2016. PMID: 28721246 Free PMC article.
Insulin tolerance tests and hyperinsulinemic-euglycemic clamp experiments revealed that alive E. hallii treatment improved insulin sensitivity compared control treatment. In addition, E. hallii treatment increased energy expenditure …
Insulin tolerance tests and hyperinsulinemic-euglycemic clamp experiments revealed that alive E. hallii treatment improved …
Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.
Franko A, Neschen S, Rozman J, Rathkolb B, Aichler M, Feuchtinger A, Brachthäuser L, Neff F, Kovarova M, Wolf E, Fuchs H, Häring HU, Peter A, Hrabě de Angelis M. Franko A, et al. Mol Metab. 2017 Jan 6;6(3):256-266. doi: 10.1016/j.molmet.2016.12.007. eCollection 2017 Mar. Mol Metab. 2017. PMID: 28271032 Free PMC article.
Furthermore, BEZ treatment improved energy expenditure and metabolic flexibility. In the liver, BEZ ameliorated steatosis, modified lipid composition and increased mitochondrial mass, which was accompanied by reduced hepatic gluconeogenesis. CONCLUSION …
Furthermore, BEZ treatment improved energy expenditure and metabolic flexibility. In the liver, BEZ ameliorated steatos …
Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet.
Murata Y, Nishio K, Mochiyama T, Konishi M, Shimada M, Ohta H, Itoh N. Murata Y, et al. PLoS One. 2013 Jul 9;8(7):e69330. doi: 10.1371/journal.pone.0069330. Print 2013. PLoS One. 2013. PMID: 23874946 Free PMC article.
BACKGROUND: A low-carbohydrate, high-fat ketogenic diet (KD) induces hepatic ketogenesis and is believed to affect energy metabolism in mice. As hepatic Fgf21 expression was markedly induced in mice fed KD, we examined the effects of KD feeding on m …
BACKGROUND: A low-carbohydrate, high-fat ketogenic diet (KD) induces hepatic ketogenesis and is believed to affect energy metaboli …
Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice.
Srivastava RA, Jahagirdar R, Azhar S, Sharma S, Bisgaier CL. Srivastava RA, et al. Mol Cell Biochem. 2006 Apr;285(1-2):35-50. doi: 10.1007/s11010-005-9053-y. Epub 2006 Feb 14. Mol Cell Biochem. 2006. PMID: 16477380
LDLr deficient mice fed HF diet and simultaneously treated with fenofibrate (100 mg/kg body weight) prevented development of obesity, lowered serum triglycerides and cholesterol, improved insulin sensitivity, and prevented accumulation of lipids in the …
LDLr deficient mice fed HF diet and simultaneously treated with fenofibrate (100 mg/kg body weight) prevented development of obesity, …
Insulin Sensitivity-Enhancing Activity of Phlorizin Is Associated with Lipopolysaccharide Decrease and Gut Microbiota Changes in Obese and Type 2 Diabetes (db/db) Mice.
Mei X, Zhang X, Wang Z, Gao Z, Liu G, Hu H, Zou L, Li X. Mei X, et al. J Agric Food Chem. 2016 Oct 12;64(40):7502-7511. doi: 10.1021/acs.jafc.6b03474. Epub 2016 Sep 27. J Agric Food Chem. 2016. PMID: 27635781
After the last treatment course, body weight, energy intake, serum lipopolysaccharides (LPS), insulin resistance, and fecal short-chain fatty acids (SCFAs) were compared. 16S rRNA gene denaturing gradient gel electrophoresis (DGGE) and quantitative PCR were u …
After the last treatment course, body weight, energy intake, serum lipopolysaccharides (LPS), insulin resistance, and f …
Butyrate mitigates metabolic dysfunctions via the ERalpha-AMPK pathway in muscle in OVX mice with diet-induced obesity.
Fu Q, Li T, Zhang C, Ma X, Meng L, Liu L, Shao K, Wu G, Zhu X, Zhao X. Fu Q, et al. Cell Commun Signal. 2023 May 4;21(1):95. doi: 10.1186/s12964-023-01119-y. Cell Commun Signal. 2023. PMID: 37143096 Free PMC article.
Oral administration of sodium butyrate (NaB) reduced the body fat content and blood lipids, increased whole-body energy expenditure, and improved insulin sensitivity. Additionally, NaB induced oestrogen receptor alpha (ERalpha) exp …
Oral administration of sodium butyrate (NaB) reduced the body fat content and blood lipids, increased whole-body energy …
27 results