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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1902 1
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1918 1
1922 1
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1926 1
1932 1
1937 1
1939 1
1940 1
1946 1
1947 3
1948 3
1949 8
1950 5
1951 2
1952 3
1953 4
1954 2
1955 2
1956 1
1957 1
1958 2
1959 3
1960 6
1961 3
1962 13
1963 6
1964 5
1965 15
1966 14
1967 17
1968 16
1969 16
1970 24
1971 10
1972 18
1973 30
1974 17
1975 59
1976 91
1977 69
1978 66
1979 105
1980 137
1981 164
1982 155
1983 153
1984 195
1985 216
1986 198
1987 196
1988 183
1989 211
1990 199
1991 198
1992 219
1993 227
1994 220
1995 236
1996 241
1997 243
1998 245
1999 271
2000 282
2001 292
2002 341
2003 350
2004 338
2005 358
2006 407
2007 409
2008 392
2009 392
2010 447
2011 491
2012 562
2013 552
2014 591
2015 586
2016 687
2017 752
2018 861
2019 937
2020 1173
2021 1345
2022 1372
2023 1285
2024 1367
2025 1808
2026 464

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21,441 results

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Page 1
Butyrate: A Double-Edged Sword for Health?
Liu H, Wang J, He T, Becker S, Zhang G, Li D, Ma X. Liu H, et al. Adv Nutr. 2018 Jan 1;9(1):21-29. doi: 10.1093/advances/nmx009. Adv Nutr. 2018. PMID: 29438462 Free PMC article. Review.
Endogenous butyrate production, delivery, and absorption by colonocytes have been well documented. ...With anti-inflammatory properties, butyrate enhances intestinal barrier function and mucosal immunity. However, the role of butyrate in obesity remains contr …
Endogenous butyrate production, delivery, and absorption by colonocytes have been well documented. ...With anti-inflammatory properti …
Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage/WNT/ERK signaling pathway.
Liang L, Liu L, Zhou W, Yang C, Mai G, Li H, Chen Y. Liang L, et al. Clin Sci (Lond). 2022 Feb 25;136(4):291-307. doi: 10.1042/CS20210778. Clin Sci (Lond). 2022. PMID: 35194640
Several studies have reported the significant role of butyrate in host-microbiota communication. However, whether butyrate provides anti-inflammatory profiles in macrophages, thus contributing to UC intestinal mucus barrier protection, has currently remained elusive …
Several studies have reported the significant role of butyrate in host-microbiota communication. However, whether butyrate pro …
Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease.
Salvi PS, Cowles RA. Salvi PS, et al. Cells. 2021 Jul 14;10(7):1775. doi: 10.3390/cells10071775. Cells. 2021. PMID: 34359944 Free PMC article. Review.
This manifests in the apparent protective effect of butyrate against colonic neoplasia. A corollary to this process is butyrate-induced inhibition of intestinal stem cells. Yet, emerging research has illustrated that the evolution of the crypt, along with butyrat …
This manifests in the apparent protective effect of butyrate against colonic neoplasia. A corollary to this process is butyrate …
Butyrate as a Potential Modulator in Gynecological Disease Progression.
Kim N, Yang C. Kim N, et al. Nutrients. 2024 Dec 4;16(23):4196. doi: 10.3390/nu16234196. Nutrients. 2024. PMID: 39683590 Free PMC article. Review.
In PCOS, butyrate aids in restoring hormonal balance, enhancing insulin sensitivity, and reducing chronic inflammation. ...However, butyrate's short half-life limits its clinical application, spurring interest in butyrate analogs and probiotics to maintain st …
In PCOS, butyrate aids in restoring hormonal balance, enhancing insulin sensitivity, and reducing chronic inflammation. ...However, …
Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression.
He Y, Ling Y, Zhang Z, Mertens RT, Cao Q, Xu X, Guo K, Shi Q, Zhang X, Huo L, Wang K, Guo H, Shen W, Shen M, Feng W, Xiao P. He Y, et al. Redox Biol. 2023 Sep;65:102822. doi: 10.1016/j.redox.2023.102822. Epub 2023 Jul 20. Redox Biol. 2023. PMID: 37494767 Free PMC article.
Herein, by performing metabolomics, we discovered that butyrate concentrations were significantly decreased in CRC patients. Butyrate supplementation sensitized CRC mice to ferroptosis induction, showing great in vivo translatability. Particularly, butyrate t …
Herein, by performing metabolomics, we discovered that butyrate concentrations were significantly decreased in CRC patients. Butyr …
Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease.
Hodgkinson K, El Abbar F, Dobranowski P, Manoogian J, Butcher J, Figeys D, Mack D, Stintzi A. Hodgkinson K, et al. Clin Nutr. 2023 Feb;42(2):61-75. doi: 10.1016/j.clnu.2022.10.024. Epub 2022 Nov 2. Clin Nutr. 2023. PMID: 36502573 Free article. Review.
Butyrate is a histone deacetylase inhibitor and also signals through three G-protein coupled receptors. It is clear that butyrate has an important role in gastrointestinal health and that butyrate levels can impact both host and microbial functions that are i …
Butyrate is a histone deacetylase inhibitor and also signals through three G-protein coupled receptors. It is clear that butyrate …
Gut Microbial Metabolite Butyrate and Its Therapeutic Role in Inflammatory Bowel Disease: A Literature Review.
Recharla N, Geesala R, Shi XZ. Recharla N, et al. Nutrients. 2023 May 11;15(10):2275. doi: 10.3390/nu15102275. Nutrients. 2023. PMID: 37242159 Free PMC article. Review.
In this review, we aim to present an overview of butyrate synthesis and metabolism and the mechanism of action of butyrate in maintaining intestinal homeostasis and to discuss the therapeutic implications of butyrate in IBD. ...However, butyrate enema …
In this review, we aim to present an overview of butyrate synthesis and metabolism and the mechanism of action of butyrate in …
Butyrate Prevents the Pathogenic Anemia-Inflammation Circuit by Facilitating Macrophage Iron Export.
Xiao P, Cai X, Zhang Z, Guo K, Ke Y, Hu Z, Song Z, Zhao Y, Yao L, Shen M, Li J, Huang Y, Ye L, Huang L, Zhang Y, Liu R, Xu M, Xu X, Zhao Y, Cao Q. Xiao P, et al. Adv Sci (Weinh). 2024 Mar;11(12):e2306571. doi: 10.1002/advs.202306571. Epub 2024 Jan 18. Adv Sci (Weinh). 2024. PMID: 38235606 Free PMC article.
Herein, it is for the first time revealed that anemic IBD patients exhibit impaired production of short-chain fatty acids (SCFAs), particularly butyrate. Butyrate supplementation restores iron metabolism in multiple anemia models. Mechanistically, butyrate up …
Herein, it is for the first time revealed that anemic IBD patients exhibit impaired production of short-chain fatty acids (SCFAs), particula …
Butyrate producers, "The Sentinel of Gut": Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics.
Singh V, Lee G, Son H, Koh H, Kim ES, Unno T, Shin JH. Singh V, et al. Front Microbiol. 2023 Jan 12;13:1103836. doi: 10.3389/fmicb.2022.1103836. eCollection 2022. Front Microbiol. 2023. PMID: 36713166 Free PMC article. Review.
They metabolize carbohydrates via the butyryl-CoA: acetate CoA-transferase pathway and butyrate kinase terminal enzymes to produce most of butyrate. Although, in minor fractions, amino acids can also be utilized to generate butyrate via glutamate and lysine p …
They metabolize carbohydrates via the butyryl-CoA: acetate CoA-transferase pathway and butyrate kinase terminal enzymes to produce mo …
Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit.
Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JFP, Heijink M, Giera M, Willems van Dijk K, Groen AK, Rensen PCN, Wang Y. Li Z, et al. Gut. 2018 Jul;67(7):1269-1279. doi: 10.1136/gutjnl-2017-314050. Epub 2017 Nov 3. Gut. 2018. PMID: 29101261
DESIGN: Acute effects of butyrate on appetite and its method of action were investigated in mice following an intragastric gavage or intravenous injection of butyrate. To study the contribution of satiety to the metabolic benefits of butyrate, mice were fed a …
DESIGN: Acute effects of butyrate on appetite and its method of action were investigated in mice following an intragastric gavage or …
21,441 results
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