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Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked co-receptor CD48 reveals a novel mechanism to modulate PD-1-dependent inhibition of human T cells.
White D, Cote-Martin A, Bleck M, Garaffa N, Shaaban A, Wu H, Liu D, Young D, Scheer J, Lorenz IC, Nixon A, Fine JS, Byrne FR, Mbow ML, Moreno-Garcia ME. White D, et al. Among authors: byrne fr. Mol Immunol. 2023 Apr;156:31-38. doi: 10.1016/j.molimm.2023.02.007. Epub 2023 Mar 6. Mol Immunol. 2023. PMID: 36889184
The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease.
Ermann J, Matmusaev M, Haley EK, Braun C, Jost F, Mayer-Wrangowski S, Hsiao P, Ting N, Li L, Terenzio D, Chime J, Lukas S, Patnaude L, Panzenbeck M, Csordas D, Zheng J, Mierz D, Simpson T, King FJ, Klimowicz AP, Mbow ML, Fine JS, Miller CA, Fogal SE, Byrne FR. Ermann J, et al. Among authors: byrne fr. Am J Physiol Gastrointest Liver Physiol. 2021 Nov 1;321(5):G500-G512. doi: 10.1152/ajpgi.00163.2021. Epub 2021 Sep 8. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34494462 Free article.
Optimization of experimental conditions for functional in vitro characterization of humanized antibodies specific for staphylococcal enterotoxin B.
MacIntyre JL, Varshney AK, Wang X, Gatto S, Friedman C, Liu Y, Kerns K, Kovalenko O, Adkins K, Zollner R, Fries BC, Byrne FR. MacIntyre JL, et al. Among authors: byrne fr. Int Immunopharmacol. 2015 Sep;28(1):354-8. doi: 10.1016/j.intimp.2015.06.025. Epub 2015 Jun 27. Int Immunopharmacol. 2015. PMID: 26130567 Free PMC article.
Humanized staphylococcal enterotoxin B (SEB)-specific monoclonal antibodies protect from SEB intoxication and Staphylococcus aureus infections alone or as adjunctive therapy with vancomycin.
Varshney AK, Wang X, MacIntyre J, Zollner RS, Kelleher K, Kovalenko OV, Pechuan X, Byrne FR, Fries BC. Varshney AK, et al. Among authors: byrne fr. J Infect Dis. 2014 Sep 15;210(6):973-81. doi: 10.1093/infdis/jiu198. Epub 2014 May 5. J Infect Dis. 2014. PMID: 24803533 Free PMC article.
Monoclonal antibodies to B and T lymphocyte attenuator (BTLA) have no effect on in vitro B cell proliferation and act to inhibit in vitro T cell proliferation when presented in a cis, but not trans, format relative to the activating stimulus.
Zhang M, Howard K, Winters A, Steavenson S, Anderson S, Smelt S, Doellgast G, Sheelo C, Stevens J, Kim H, Hamburger A, Sein A, Caughey DJ, Lee F, Hsu H, Siu G, Byrne FR. Zhang M, et al. Among authors: byrne fr. Clin Exp Immunol. 2011 Jan;163(1):77-87. doi: 10.1111/j.1365-2249.2010.04259.x. Epub 2010 Nov 16. Clin Exp Immunol. 2011. PMID: 21078085 Free PMC article.
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