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Page 1
Did you mean c briganti[Author] (156 results)?
Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle.
Mistretta M, Fiorito V, Allocco AL, Ammirata G, Hsu MY, Digiovanni S, Belicchi M, Napoli L, Ripolone M, Trombetta E, Mauri P, Farini A, Meregalli M, Villa C, Porporato PE, Miniscalco B, Crich SG, Riganti C, Torrente Y, Tolosano E. Mistretta M, et al. Among authors: riganti c. Cell Rep. 2024 Mar 26;43(3):113854. doi: 10.1016/j.celrep.2024.113854. Epub 2024 Feb 26. Cell Rep. 2024. PMID: 38412099 Free article.
Here, we generate a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and show that, by sustaining heme synthesis, FLVCR1a contributes to determine the energy phenotype in skeletal muscle cells and to modulate satellite ce …
Here, we generate a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and show tha …
Doxorubicin-antioxidant co-drugs.
Chegaev K, Riganti C, Rolando B, Lazzarato L, Gazzano E, Guglielmo S, Ghigo D, Fruttero R, Gasco A. Chegaev K, et al. Among authors: riganti c. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5307-10. doi: 10.1016/j.bmcl.2013.07.070. Epub 2013 Aug 8. Bioorg Med Chem Lett. 2013. PMID: 23973213 Free article.
Doxorubicin-antioxidant multitarget compounds 6 and 7 were obtained by combining doxorubicin (DOX) with caffeic and ferulic acids through an ester linkage at C-14. The products were studied in in vitro models of cardiomyocytes and breast cancer cells, characterized by diff …
Doxorubicin-antioxidant multitarget compounds 6 and 7 were obtained by combining doxorubicin (DOX) with caffeic and ferulic acids through an …
Integrating vosoritide therapy with limb surgery in paediatric patients with achondroplasia: real-life experiences.
Allegri AEM, Bedeschi MF, Bocchi MB, Camurri V, Gonfiantini MV, Leoni C, Mariani M, Palmacci O, Porro M, Riganti S, Tedesco C, Rinaldi B, Scarano E, Schiavariello C, Selicorni A, Stagi S, Verdoni F, Zampino G, Maghnie M, Onesimo R. Allegri AEM, et al. Among authors: riganti s. Orphanet J Rare Dis. 2025 Jul 17;20(1):369. doi: 10.1186/s13023-025-03853-7. Orphanet J Rare Dis. 2025. PMID: 40676599 Free PMC article.
Until 2021, there were no precision treatments available, and in some countries, elective surgery was considered a standard approach to increase height, improve body proportions, enhance functionality, and correct deformities in a selected group of patients. Recently, C-ty …
Until 2021, there were no precision treatments available, and in some countries, elective surgery was considered a standard approach to incr …
Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus.
Bertino F, Mukherjee D, Bonora M, Bagowski C, Nardelli J, Metani L, Zanin Venturini DI, Chianese D, Santander N, Salaroglio IC, Hentschel A, Quarta E, Genova T, McKinney AA, Allocco AL, Fiorito V, Petrillo S, Ammirata G, De Giorgio F, Dennis E, Allington G, Maier F, Shoukier M, Gloning KP, Munaron L, Mussano F, Salsano E, Pareyson D, di Rocco M, Altruda F, Panagiotakos G, Kahle KT, Gressens P, Riganti C, Pinton PP, Roos A, Arnold T, Tolosano E, Chiabrando D. Bertino F, et al. Among authors: riganti c. Cell Rep Med. 2024 Jul 16;5(7):101647. doi: 10.1016/j.xcrm.2024.101647. Cell Rep Med. 2024. PMID: 39019006 Free PMC article.
Here, we identify FLVCR1 (feline leukemia virus subgroup C receptor 1) as a gene responsible for a severe form of CH in humans and mice. Mechanistically, our data reveal that the full-length isoform encoded by the FLVCR1 gene, FLVCR1a, interacts with the IP3R3-VDAC complex …
Here, we identify FLVCR1 (feline leukemia virus subgroup C receptor 1) as a gene responsible for a severe form of CH in humans and mi …
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance.
Schirizzi A, Renna N, De Leonardis G, Montanaro R, Mastropasqua F, Graziano G, Riganti C, Pisano I, Laghezza A, Abate C, Stefanachi A, Colabufo NA, Caccioppoli C, Bianco G, Valentini AM, Armentano R, Giannelli G, Contino M, D'Alessandro R. Schirizzi A, et al. Among authors: riganti c. J Exp Clin Cancer Res. 2025 Jul 16;44(1):209. doi: 10.1186/s13046-025-03476-7. J Exp Clin Cancer Res. 2025. PMID: 40665405 Free PMC article.
Mitochondrial energetic failure underlies FLVCR1-related sensory neuropathy.
Bertino F, Zanin Venturini DI, Grasso E, Kopecka J, Salio C, Gnutti B, Basnet RM, Bellini S, Mignani L, Zhao B, Kleefeld F, Hentschel A, Magnani F, Fiorito V, Abalai RE, Metani L, Allocco AL, Petrillo S, De Giorgio F, Ammirata G, Salsano E, Pareyson D, di Rocco M, Abicht A, McCourt E, Horvath R, Kölbel H, Larson A, Roos A, Yu TW, Finazzi D, Riganti C, Tolosano E, Chiabrando D. Bertino F, et al. Among authors: riganti c. Commun Biol. 2026 Feb 14;9(1):429. doi: 10.1038/s42003-026-09691-y. Commun Biol. 2026. PMID: 41691085 Free PMC article.
Understanding the underlying molecular mechanism is fundamental to improve the treatment of patients affected by these rare disorders. Feline Leukemia Virus Subgroup C Receptor 1 (FLVCR1) is one of the genes previously associated with sensory neuropathy that requires furth …
Understanding the underlying molecular mechanism is fundamental to improve the treatment of patients affected by these rare disorders. Felin …
Fighting Multidrug Resistance with Ruthenium-Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition.
Teixeira RG, Salaroglio IC, Oliveira NFB, Sequeira JGN, Fontrodona X, Romero I, Machuqueiro M, Tomaz AI, Garcia MH, Riganti C, Valente A. Teixeira RG, et al. Among authors: riganti c. J Med Chem. 2023 Oct 26;66(20):14080-14094. doi: 10.1021/acs.jmedchem.3c01120. Epub 2023 Aug 24. J Med Chem. 2023. PMID: 37616241 Free PMC article.
As such, a new series of ruthenium-cyclopentadienyl ("RuCp") compounds with the general formula [Ru(eta(5)-C(5)H(4)R)(4,4'-R'-2,2'-bipy)(PPh(3))] were prepared and fully characterized. All compounds were evaluated toward non-small cell lung cancer cells with different degr …
As such, a new series of ruthenium-cyclopentadienyl ("RuCp") compounds with the general formula [Ru(eta(5)-C(5)H(4)R)(4,4'-R'-2,2'-bi …
Click ferrocenyl-erlotinib conjugates active against erlotinib-resistant non-small cell lung cancer cells in vitro.
Biegański P, Godel M, Riganti C, Kawano DF, Kopecka J, Kowalski K. Biegański P, et al. Among authors: riganti c. Bioorg Chem. 2022 Feb;119:105514. doi: 10.1016/j.bioorg.2021.105514. Epub 2021 Nov 24. Bioorg Chem. 2022. PMID: 34864281
Among the series of investigated compounds two isomers commonly bearing C(O)CH(2)CH(2) spacer have shown superior to erlotinib activity against erlotinib-resistant H1650 and H1975 cells whereas compound with short methylene spacer devoid of any activity. ...
Among the series of investigated compounds two isomers commonly bearing C(O)CH(2)CH(2) spacer have shown superior to erlotinib activi …
71 results