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How Strain-Release Determines Chemoselectivity: A Mechanistic Study of Rhodium-Catalyzed Bicyclo[1.1.0]butane Activation.
Lai W, Zhong K, Liu S, Liu S, Chen H, Ni H, Zeng Z, Zhao Z, Lan Y, Bai R. Lai W, et al. J Phys Chem Lett. 2022 Aug 25;13(33):7694-7701. doi: 10.1021/acs.jpclett.2c01528. Epub 2022 Aug 12. J Phys Chem Lett. 2022. PMID: 35960186
In this work, three BCB-activation modes in Rh-catalyzed BCB transformations that construct diastereoselective alpha-quaternary beta-lactones were investigated by density functional theory calculations. Our results show that, compared with C1-C3 insertion and C-C3 o …
In this work, three BCB-activation modes in Rh-catalyzed BCB transformations that construct diastereoselective alpha-quaternary beta-lactone …
Cycloastragenol and Astragaloside IV activate telomerase and protect nucleus pulposus cells against high glucose-induced senescence and apoptosis.
Hong H, Xiao J, Guo Q, Du J, Jiang Z, Lu S, Zhang H, Zhang X, Wang X. Hong H, et al. Exp Ther Med. 2021 Nov;22(5):1326. doi: 10.3892/etm.2021.10761. Epub 2021 Sep 20. Exp Ther Med. 2021. PMID: 34630680 Free PMC article.
Results demonstrated an upregulation in the expression levels of p16, c-C3 and BAX, and increased beta-Gal staining; while the expression level of Bcl-2 was downregulated in a concentration-dependent manner. Pre-treatment of the NPCs with CAG and AG-IV downregulated …
Results demonstrated an upregulation in the expression levels of p16, c-C3 and BAX, and increased beta-Gal staining; while the …
Serum complement C3 and α2-macroglobulin are potentially useful biomarkers for inflammatory bowel disease patients.
Okada K, Itoh H, Ikemoto M. Okada K, et al. Heliyon. 2021 Mar 23;7(3):e06554. doi: 10.1016/j.heliyon.2021.e06554. eCollection 2021 Mar. Heliyon. 2021. PMID: 33851052 Free PMC article.
Hence, the serum levels of c-C3 and alpha(2)-MG could be good indicators of the severity of UC. CONCLUSION: Serum c-C3 and alpha(2)-MG are suitable biomarkers for monitoring the condition of patients with UC....
Hence, the serum levels of c-C3 and alpha(2)-MG could be good indicators of the severity of UC. CONCLUSION: Serum c- …
Correlation between SARS-COV-2 antibody screening by immunoassay and neutralizing antibody testing.
Mendrone-Junior A, Dinardo CL, Ferreira SC, Nishya A, Salles NA, de Almeida Neto C, Hamasaki DT, Facincani T, de Oliveira Alves LB, Machado RRG, Araujo DB, Durigon EL, Rocha V, Sabino EC. Mendrone-Junior A, et al. Transfusion. 2021 Apr;61(4):1181-1190. doi: 10.1111/trf.16268. Epub 2021 Jan 25. Transfusion. 2021. PMID: 33491194 Free PMC article.
Regarding the studied criteria for identifying CP donors with high nAbs titers: (a) C1 showed 76.1% accuracy if S/CO = 4.65, (b) C2 presented 76.1% accuracy if S/CO 4.57 and (c) C3 had 71.6% accuracy if S/CO was 4.57 or if S/CO was between 2.68-4.57 and the last COV …
Regarding the studied criteria for identifying CP donors with high nAbs titers: (a) C1 showed 76.1% accuracy if S/CO = 4.65, (b) C2 presente …
Self-Assembled Supramolecular Bilayer Nanoparticles Composed of Near-Infrared Dye as a Theranostic Nanoplatform To Encapsulate Hydrophilic Drugs Effectively.
Jeong C, Noh I, Rejinold NS, Kim J, Jon S, Kim YC. Jeong C, et al. ACS Biomater Sci Eng. 2020 Jan 13;6(1):474-484. doi: 10.1021/acsbiomaterials.9b01587. Epub 2019 Dec 3. ACS Biomater Sci Eng. 2020. PMID: 33463245
This method is innovative not only due to formation of the theranostic nanoparticle for immiscible hydrophilic drug delivery but also because of generation of strong fluorescence signals due to the Cy-C dyes on the surfaces of the NPs. In this study, Cy-C (C = C3, C …
This method is innovative not only due to formation of the theranostic nanoparticle for immiscible hydrophilic drug delivery but also becaus …
Honokiol inhibits the growth of SKBR3 cells.
Shi H, Wang Y, Yao M, Zhang D, Fang W, Zhou T, Gan D, Yue S, Qian H, Chen T. Shi H, et al. Transl Cancer Res. 2020 Dec;9(12):7596-7604. doi: 10.21037/tcr-20-3110. Transl Cancer Res. 2020. PMID: 35117359 Free PMC article.
Intracellular accumulation of apoptosis-related proteins Bcl-xl and caspase-3 decreased but C-C3 increased. We also found downregulation of MMP-2 expression, a protein related to invasion and migration (P<0.01), and a decrease in the expression levels of the Wnt/ …
Intracellular accumulation of apoptosis-related proteins Bcl-xl and caspase-3 decreased but C-C3 increased. We also found down …
Phase-amplitude coupling of delta brush unveiling neuronal modulation development in the neonatal brain.
Shibata T, Otsubo H. Shibata T, et al. Neurosci Lett. 2020 Sep 14;735:135211. doi: 10.1016/j.neulet.2020.135211. Epub 2020 Jun 25. Neurosci Lett. 2020. PMID: 32593774
We calculated the modulation index (MI), direct mean vector length (dMVL), and mean of phase angle of coupling by PAC between slow waves (0.5-1.5 Hz) and fast activities (8-25 Hz) in four regions (F: Fp1 and Fp2, C: C3 and C4, T: T3 and T4, O: O1 and O2). RESULTS: W …
We calculated the modulation index (MI), direct mean vector length (dMVL), and mean of phase angle of coupling by PAC between slow waves (0. …
Analysis of Four Polymorphisms Located at the Promoter of the Estrogen Receptor Alpha ESR1 Gene in a Population With Gender Incongruence.
Fernández R, Delgado-Zayas E, Ramírez K, Cortés-Cortés J, Gómez-Gil E, Esteva I, Almaraz MC, Guillamon A, Pásaro E. Fernández R, et al. Sex Med. 2020 Sep;8(3):490-500. doi: 10.1016/j.esxm.2020.04.002. Epub 2020 May 12. Sex Med. 2020. PMID: 32409288 Free PMC article.
The analyzed polymorphisms were in linkage disequilibrium. In the trans men population, the T(C1)-L(C2)-C(C3)-A(C4) haplotype was overrepresented (P = .019) while the T(C1)-L(C2)-C(C3)-G(C4) was subrepresented (P = .005). ...
The analyzed polymorphisms were in linkage disequilibrium. In the trans men population, the T(C1)-L(C2)-C(C3)-A(C4) haplotype …
Impact of UV radiation on DOM transformation on molecular level using FT-ICR-MS and PARAFAC.
Miranda ML, Osterholz H, Giebel HA, Bruhnke P, Dittmar T, Zielinski O. Miranda ML, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 5;230:118027. doi: 10.1016/j.saa.2020.118027. Epub 2020 Jan 7. Spectrochim Acta A Mol Biomol Spectrosc. 2020. PMID: 31986429
Parallel factor analysis (PARAFAC) indicated the presence of three main components in all treatments: C1 (Marine humic M), C2 (Bacterial produced humic C), C3 (Tyrosine), and an additional component in the dark incubation of mesocosm 3, C4 (Tryptophan). ...
Parallel factor analysis (PARAFAC) indicated the presence of three main components in all treatments: C1 (Marine humic M), C2 (Bacterial pro …
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