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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1807 1
1825 1
1826 1
1868 1
1913 1
1936 1
1947 1
1949 1
1951 1
1956 1
1960 1
1962 1
1963 2
1964 2
1965 7
1967 3
1968 5
1969 4
1970 5
1971 5
1972 7
1973 5
1974 6
1975 9
1976 17
1977 9
1978 7
1979 14
1980 20
1981 21
1982 10
1983 17
1984 23
1985 28
1986 22
1987 29
1988 36
1989 35
1990 50
1991 52
1992 67
1993 59
1994 61
1995 46
1996 54
1997 57
1998 49
1999 67
2000 79
2001 83
2002 83
2003 86
2004 82
2005 101
2006 90
2007 115
2008 117
2009 151
2010 138
2011 145
2012 161
2013 148
2014 198
2015 237
2016 249
2017 251
2018 280
2019 225
2020 238
2021 239
2022 230
2023 221
2024 177

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4,624 results

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Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial.
Grebely J, Dalgard O, Conway B, Cunningham EB, Bruggmann P, Hajarizadeh B, Amin J, Bruneau J, Hellard M, Litwin AH, Marks P, Quiene S, Siriragavan S, Applegate TL, Swan T, Byrne J, Lacalamita M, Dunlop A, Matthews GV, Powis J, Shaw D, Thurnheer MC, Weltman M, Kronborg I, Cooper C, Feld JJ, Fraser C, Dillon JF, Read P, Gane E, Dore GJ; SIMPLIFY Study Group. Grebely J, et al. Among authors: shaw d. Lancet Gastroenterol Hepatol. 2018 Mar;3(3):153-161. doi: 10.1016/S2468-1253(17)30404-1. Epub 2018 Jan 6. Lancet Gastroenterol Hepatol. 2018. PMID: 29310928 Free article. Clinical Trial.
BACKGROUND: Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to treat recent PWID. This study aimed to evaluate the efficacy of sofosbuvir and velpatasvir th …
BACKGROUND: Despite revised guidelines that no longer exclude people who inject drugs (PWID) from treatment for hepatitis C virus (HC …
Pseudokinases from a structural perspective.
Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. Taylor SS, et al. Among authors: shaw a. Biochem Soc Trans. 2013 Aug;41(4):981-6. doi: 10.1042/BST20130120. Biochem Soc Trans. 2013. PMID: 23863167 Free PMC article. Review.
The catalytic (C) subunit of PKA was the first protein kinase structure to be solved, and it continues to serve as the prototype for the protein kinase superfamily. ...The C-spine is thus fused. However, the A481F mutant is still capable of binding wild-type B-Raf a …
The catalytic (C) subunit of PKA was the first protein kinase structure to be solved, and it continues to serve as the prototype for …
Truncating Variants in RFC1 in Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome.
Ronco R, Perini C, Currò R, Dominik N, Facchini S, Gennari A, Simone R, Stuart S, Nagy S, Vegezzi E, Quartesan I, El-Saddig A, Lavin T, Tucci A, Szymura A, Novis De Farias LE, Gary A, Delfeld M, Kandikatla P, Niu N, Tawde S, Shaw J, Polke J, Reilly MM, Wood NW, Crespan E, Gomez C, Chen JYH, Schmahmann JD, Gosal D, Houlden H, Das S, Cortese A. Ronco R, et al. Among authors: shaw j. Neurology. 2023 Jan 31;100(5):e543-e554. doi: 10.1212/WNL.0000000000201486. Epub 2022 Oct 26. Neurology. 2023. PMID: 36289003 Free PMC article.
RESULTS: We identified 7 patients from 5 unrelated families with clinically defined CANVAS carrying a heterozygous (AAGGG)(n) expansion together with a second truncating variant in trans in RFC1, which included the following: c.1267C>T (p.Arg423Ter), c.1739_1740d …
RESULTS: We identified 7 patients from 5 unrelated families with clinically defined CANVAS carrying a heterozygous (AAGGG)(n) expansion toge …
TBK1 has a new Akt.
Shaw LM. Shaw LM. J Biol Chem. 2021 Oct;297(4):101244. doi: 10.1016/j.jbc.2021.101244. Epub 2021 Sep 24. J Biol Chem. 2021. PMID: 34563542 Free PMC article.
Proteome of Coxiella burnetii.
Ihnatko R, Shaw E, Toman R. Ihnatko R, et al. Among authors: shaw e. Adv Exp Med Biol. 2012;984:105-30. doi: 10.1007/978-94-007-4315-1_6. Adv Exp Med Biol. 2012. PMID: 22711629 Review.
Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogen's physiology and offered new possibilities in investigations of inter- or intra-species relatedness. ...Given these advances, proteomics may make mark …
Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogen's physiolo …
HIV-1 Vpu Mediates HLA-C Downregulation.
Apps R, Del Prete GQ, Chatterjee P, Lara A, Brumme ZL, Brockman MA, Neil S, Pickering S, Schneider DK, Piechocka-Trocha A, Walker BD, Thomas R, Shaw GM, Hahn BH, Keele BF, Lifson JD, Carrington M. Apps R, et al. Among authors: shaw gm. Cell Host Microbe. 2016 May 11;19(5):686-95. doi: 10.1016/j.chom.2016.04.005. Cell Host Microbe. 2016. PMID: 27173934 Free PMC article.
HLA-C reduction is mediated by viral Vpu and reduces the ability of HLA-C restricted CTLs to suppress viral replication in CD4+ cells in vitro. ...HIV-2 also suppresses HLA-C expression through distinct mechanisms, underscoring the immune pressure HLA-C …
HLA-C reduction is mediated by viral Vpu and reduces the ability of HLA-C restricted CTLs to suppress viral replication in CD4 …
C-peptide as a Therapy for Kidney Disease: A Systematic Review and Meta-Analysis.
Shaw JA, Shetty P, Burns KD, Fergusson D, Knoll GA. Shaw JA, et al. PLoS One. 2015 May 20;10(5):e0127439. doi: 10.1371/journal.pone.0127439. eCollection 2015. PLoS One. 2015. PMID: 25993479 Free PMC article. Review.
C-peptide has intrinsic biological activity and may be renoprotective. We conducted a systematic review to determine whether C-peptide had a beneficial effect on renal outcomes. ...Reduction in albuminuria was also reported in the C-peptide group (p<0.05). …
C-peptide has intrinsic biological activity and may be renoprotective. We conducted a systematic review to determine whether C …
Exploring the heterogeneous transcriptional response of the CNS to systemic LPS and Poly(I:C).
Bormann D, Copic D, Klas K, Direder M, Riedl CJ, Testa G, Kühtreiber H, Poreba E, Hametner S, Golabi B, Salek M, Haider C, Endmayr V, Shaw LE, Höftberger R, Ankersmit HJ, Mildner M. Bormann D, et al. Among authors: shaw le. Neurobiol Dis. 2023 Nov;188:106339. doi: 10.1016/j.nbd.2023.106339. Epub 2023 Oct 31. Neurobiol Dis. 2023. PMID: 37913832 Free article.
Here we utilized single nuclei RNA sequencing (snRNAseq), serum proteome profiling and primary cell culture methods to systematically compare the acute response of the mammalian brain to the bacterial PAMP lipopolysaccharide (LPS) and the viral PAMP polyinosinic:polycytidylic aci …
Here we utilized single nuclei RNA sequencing (snRNAseq), serum proteome profiling and primary cell culture methods to systematically compar …
Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin.
Lee CT, Huang KS, Shaw JF, Chen JR, Kuo WS, Shen G, Grumezescu AM, Holban AM, Wang YT, Wang JS, Hsiang YP, Lin YM, Hsu HH, Yang CH. Lee CT, et al. Among authors: shaw jf. Front Pharmacol. 2020 Nov 30;11:575704. doi: 10.3389/fphar.2020.575704. eCollection 2020. Front Pharmacol. 2020. PMID: 33328984 Free PMC article. Review.
A crucial pharmacological effect of C. militaris is immunomodulation. In this review, we catalog the immunomodulatory effects of different extracts of C. militaris, namely total extracts, polysaccharides and cordycepin. Total extracts obtained using water or 50% eth …
A crucial pharmacological effect of C. militaris is immunomodulation. In this review, we catalog the immunomodulatory effects of diff …
4,624 results