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63 results

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Page 1
The CDD System in Computed Tomographic Diagnosis of Diverticular Disease.
Pustelnik D, Elsholtz FHJ, Bojarski C, Hamm B, Niehues SM. Pustelnik D, et al. Among authors: bojarski c. Rofo. 2017 Aug;189(8):740-747. doi: 10.1055/s-0043-110770. Epub 2017 Jun 26. Rofo. 2017. PMID: 28651260 Free article. Review. English.
Citation Format . Pustelnik D, Elsholtz FH, Bojarski C et al. The CDD System in Computed Tomographic Diagnosis of Diverticular Disease. Fortschr Rontgenstr 2017; 189: 740 - 747....
Citation Format . Pustelnik D, Elsholtz FH, Bojarski C et al. The CDD System in Computed Tomographic Diagnosis of Diverticular Diseas …
Gαi-derived peptide binds the µ-opioid receptor.
Kossoń P, Dyniewicz J, Lipiński PFJ, Matalińska J, Misicka A, Bojarski AJ, Mordalski S. Kossoń P, et al. Among authors: bojarski aj. Pharmacol Rep. 2023 Apr;75(2):465-473. doi: 10.1007/s43440-023-00457-5. Epub 2023 Feb 25. Pharmacol Rep. 2023. PMID: 36840824 Free PMC article.
Agonist binding to the receptor stimulates GDP/GTP exchange within the heterotrimeric G protein complex, whereas recent structures of GPCR-G protein complexes revealed that the H5, S1 and S2 domains of Galpha are involved in binding the active receptor, earlier studies showed tha …
Agonist binding to the receptor stimulates GDP/GTP exchange within the heterotrimeric G protein complex, whereas recent structures of GPCR-G …
Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S. El Khamlichi C, et al. Among authors: bojarski aj. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2118847119. doi: 10.1073/pnas.2118847119. Epub 2022 May 20. Proc Natl Acad Sci U S A. 2022. PMID: 35594393 Free PMC article.
In this study, we showed that Serodolin is unique among a number of agonists and antagonists tested: it behaves as an antagonist/inverse agonist on Gs signaling while inducing ERK activation through a beta-arrestin-dependent signaling mechanism that requires c-SRC activati …
In this study, we showed that Serodolin is unique among a number of agonists and antagonists tested: it behaves as an antagonist/inverse ago …
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update.
Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, Castillejo G, De Magistris L, Dieterich W, Di Liberto D, Elli L, Fasano A, Hadjivassiliou M, Kurien M, Lionetti E, Mulder CJ, Rostami K, Sapone A, Scherf K, Schuppan D, Trott N, Volta U, Zevallos V, Zopf Y, Sanders DS. Catassi C, et al. Among authors: bojarski c. Nutrients. 2017 Nov 21;9(11):1268. doi: 10.3390/nu9111268. Nutrients. 2017. PMID: 29160841 Free PMC article. Review.
Mining anion-aromatic interactions in the Protein Data Bank.
Kuzniak-Glanowska E, Glanowski M, Kurczab R, Bojarski AJ, Podgajny R. Kuzniak-Glanowska E, et al. Among authors: bojarski aj. Chem Sci. 2022 Mar 1;13(14):3984-3998. doi: 10.1039/d2sc00763k. eCollection 2022 Apr 6. Chem Sci. 2022. PMID: 35440982 Free PMC article.
The use of a scarcely exploited (x, h) coordinate system led to (i) identification of three separate areas of motif accumulation: A - over the ring, B - over the ring-substituent bonds, and C - roughly in the plane of the aromatic ring, and (ii) unprecedented simultaneous …
The use of a scarcely exploited (x, h) coordinate system led to (i) identification of three separate areas of motif accumulation: A - over t …
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT(1A) activity. Part 5.
Gomółka A, Ciesielska A, Wróbel MZ, Chodkowski A, Kleps J, Dawidowski M, Siwek A, Wolak M, Stachowicz K, Sławińska A, Nowak G, Satała G, Bojarski AJ, Belka M, Ulenberg S, Bączek T, Skowronek P, Turło J, Herold F. Gomółka A, et al. Among authors: bojarski aj. Eur J Med Chem. 2015 Jun 15;98:221-36. doi: 10.1016/j.ejmech.2015.05.003. Epub 2015 May 9. Eur J Med Chem. 2015. PMID: 26043160
A series of novel 4-aryl-pyrido[1,2-c]pyrimidine derivatives containing a 1-(2-quinoline)piperazine moiety was synthesized. The chemical structure of new compounds was confirmed by FT-IR, (1)H NMR, (13)C NMR and HRMS spectra as well as elemental analysis. Affinity o …
A series of novel 4-aryl-pyrido[1,2-c]pyrimidine derivatives containing a 1-(2-quinoline)piperazine moiety was synthesized. The chemi …
Hydrogen Bonds with Fluorine in Ligand-Protein Complexes-the PDB Analysis and Energy Calculations.
Pietruś W, Kafel R, Bojarski AJ, Kurczab R. Pietruś W, et al. Among authors: bojarski aj. Molecules. 2022 Feb 2;27(3):1005. doi: 10.3390/molecules27031005. Molecules. 2022. PMID: 35164270 Free PMC article.
In this study, a statistical analysis of the nature, geometry, and frequency of hydrogen bonds (HBs) formed between the aromatic and aliphatic C-F groups of small molecules and biological targets found in the Protein Data Bank (PDB) repository was presented. ...
In this study, a statistical analysis of the nature, geometry, and frequency of hydrogen bonds (HBs) formed between the aromatic and aliphat …
2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT6 Receptor Inverse Agonists with Cognition-Enhancing Activity.
Drop M, Canale V, Chaumont-Dubel S, Kurczab R, Satała G, Bantreil X, Walczak M, Koczurkiewicz-Adamczyk P, Latacz G, Gwizdak A, Krawczyk M, Gołębiowska J, Grychowska K, Bojarski AJ, Nikiforuk A, Subra G, Martinez J, Pawłowski M, Popik P, Marin P, Lamaty F, Zajdel P. Drop M, et al. Among authors: bojarski aj. ACS Chem Neurosci. 2021 Apr 7;12(7):1228-1240. doi: 10.1021/acschemneuro.1c00061. Epub 2021 Mar 11. ACS Chem Neurosci. 2021. PMID: 33705101 Free PMC article.
Herein, we report on degradation of the 1H-pyrrolo[3,2-c]quinoline scaffold to provide the 2-phenyl-1H-pyrrole-3-carboxamide, which is devoid of canonical indole-like skeleton and retains recognition of 5-HT(6)R. ...
Herein, we report on degradation of the 1H-pyrrolo[3,2-c]quinoline scaffold to provide the 2-phenyl-1H-pyrrole-3-carboxamide, which i …
GPCRdb in 2018: adding GPCR structure models and ligands.
Pándy-Szekeres G, Munk C, Tsonkov TM, Mordalski S, Harpsøe K, Hauser AS, Bojarski AJ, Gloriam DE. Pándy-Szekeres G, et al. Among authors: bojarski aj. Nucleic Acids Res. 2018 Jan 4;46(D1):D440-D446. doi: 10.1093/nar/gkx1109. Nucleic Acids Res. 2018. PMID: 29155946 Free PMC article.
Models are provided for inactive, intermediate and active states-except for classes C and F that so far only have inactive templates. The ligand database has separate browsers for: (i) target selection by receptor, family or class, (ii) ligand filtering based on cross-expe …
Models are provided for inactive, intermediate and active states-except for classes C and F that so far only have inactive templates. …
63 results