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Year Number of Results
2010 1
2012 5
2013 4
2014 1
2015 1
2020 0
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Page 1
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.
Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P, Nock G, Strömstedt M, Enerback M, Chelala C, Graupera M, Carroll J, Cosulich S, Saunders PT, Huhtaniemi I, Vanhaesebroeck B. Guillermet-Guibert J, et al. PLoS Genet. 2015 Jul 1;11(7):e1005304. doi: 10.1371/journal.pgen.1005304. eCollection 2015 Jul. PLoS Genet. 2015. PMID: 26132308 Free PMC article.
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.
Soler A, Serra H, Pearce W, Angulo A, Guillermet-Guibert J, Friedman LS, Viñals F, Gerhardt H, Casanovas O, Graupera M, Vanhaesebroeck B. Soler A, et al. J Exp Med. 2013 Sep 23;210(10):1937-45. doi: 10.1084/jem.20121571. Epub 2013 Sep 16. J Exp Med. 2013. PMID: 24043760 Free PMC article.
AKT-ing out: SGK kinases come to the fore.
Moniz LS, Vanhaesebroeck B. Moniz LS, et al. Biochem J. 2013 Jun 15;452(3):e11-3. doi: 10.1042/BJ20130617. Biochem J. 2013. PMID: 23725458
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V, Vanhaesebroeck B. Aksoy E, et al. Nat Immunol. 2012 Nov;13(11):1045-1054. doi: 10.1038/ni.2426. Epub 2012 Sep 30. Nat Immunol. 2012. PMID: 23023391 Free PMC article.
Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
Foukas LC, Berenjeno IM, Gray A, Khwaja A, Vanhaesebroeck B. Foukas LC, et al. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11381-6. doi: 10.1073/pnas.0906461107. Epub 2010 Jun 7. Proc Natl Acad Sci U S A. 2010. PMID: 20534549 Free PMC article.
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