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FAM50A drives breast cancer brain metastasis through interaction with C9ORF78 to enhance L-asparagine production.
Chen W, Qin Y, Qiao L, Liu X, Gao C, Li TR, Luo Y, Li D, Yan H, Han L, Hai L, Nie F, Wu HB, Chen C, Ping YF, Bian XW. Chen W, et al. Sci Adv. 2025 Jun 20;11(25):eadt3075. doi: 10.1126/sciadv.adt3075. Epub 2025 Jun 18. Sci Adv. 2025. PMID: 40531994 Free PMC article.
Elevated levels of asparagine, catalyzed by asparagine synthetase (ASNS), have been identified as a prerequisite for lung metastasis in breast cancer. However, the roles and regulatory mechanisms of ASNS in breast cancer brain metastasis (BCBM) are not well understo …
Elevated levels of asparagine, catalyzed by asparagine synthetase (ASNS), have been identified as a prerequisite for lung metastasis in brea …
AGO2-RIP-Seq reveals miR-34/miR-449 cluster targetome in sinonasal cancers.
Tomasetti M, Monaco F, Rubini C, Rossato M, De Quattro C, Beltrami C, Sollini G, Pasquini E, Amati M, Goteri G, Santarelli L, Re M. Tomasetti M, et al. PLoS One. 2024 Jan 12;19(1):e0295997. doi: 10.1371/journal.pone.0295997. eCollection 2024. PLoS One. 2024. PMID: 38215077 Free PMC article.
Many studies emphasize the role of specific miRNA in the development and progression of cancer, and their expression profiles could be used as prognostic biomarkers to predict the survival. ...Using this approach, we identified direct target genes (targetome), which were i …
Many studies emphasize the role of specific miRNA in the development and progression of cancer, and their expression profiles could b …
Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.
Wang J, Tadeo X, Hou H, Andrews S, Moresco JJ, Yates JR 3rd, Nagy PL, Jia S. Wang J, et al. Nucleic Acids Res. 2014 Oct;42(18):11419-32. doi: 10.1093/nar/gku842. Epub 2014 Sep 22. Nucleic Acids Res. 2014. PMID: 25245948 Free PMC article.
In addition to its role in telomeric heterochromatin assembly, Tls1-mediated splicing of shelterin mRNAs also regulates telomere length. Given that its human homologue C9ORF78 also associates with the spliceosome and is overexpressed in multiple cancer cell lines, o …
In addition to its role in telomeric heterochromatin assembly, Tls1-mediated splicing of shelterin mRNAs also regulates telomere length. Giv …
Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults.
Gorello P, La Starza R, Varasano E, Chiaretti S, Elia L, Pierini V, Barba G, Brandimarte L, Crescenzi B, Vitale A, Messina M, Grammatico S, Mancini M, Matteucci C, Bardi A, Guarini A, Martelli MF, Foà R, Mecucci C. Gorello P, et al. Haematologica. 2010 Jan;95(1):79-86. doi: 10.3324/haematol.2009.010413. Haematologica. 2010. PMID: 20065082 Free PMC article.
In two cases with cryptic del(9)(q34), fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction detected the TAF_INUP214 fusion and gene expression profiling identified a signature characterized by HOXA and NUP214 upregulation and TAF_I, FNBP1, C9 …
In two cases with cryptic del(9)(q34), fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction detected the T …