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Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade.
Datta J, Majumder S, Kutay H, Motiwala T, Frankel W, Costa R, Cha HC, MacDougald OA, Jacob ST, Ghoshal K. Datta J, et al. Cancer Res. 2007 Mar 15;67(6):2736-46. doi: 10.1158/0008-5472.CAN-06-4433. Cancer Res. 2007. PMID: 17363595 Free PMC article.