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Year Number of Results
2008 2
2009 1
2011 1
2012 2
2013 2
2015 1
2016 1
2018 1
2019 1
2021 0
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Page 1
Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis.
Zhao H, Martin E, Matalkah F, Shah N, Ivanov A, Ruppert JM, Lockman PR, Agazie YM. Zhao H, et al. Oncogene. 2019 Mar;38(13):2275-2290. doi: 10.1038/s41388-018-0574-8. Epub 2018 Nov 22. Oncogene. 2019. PMID: 30467378 Free PMC article.
Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.
Zhao H, Agazie YM. Zhao H, et al. BMC Cancer. 2015 Mar 8;15:109. doi: 10.1186/s12885-015-1131-2. BMC Cancer. 2015. PMID: 25885600 Free PMC article.
Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.
Zhou X, Agazie YM. Zhou X, et al. J Biol Chem. 2009 May 1;284(18):12226-34. doi: 10.1074/jbc.M900020200. Epub 2009 Mar 4. J Biol Chem. 2009. PMID: 19261604 Free PMC article.
SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer.
Matalkah F, Martin E, Zhao H, Agazie YM. Matalkah F, et al. Breast Cancer Res. 2016 Jan 4;18(1):2. doi: 10.1186/s13058-015-0659-z. Breast Cancer Res. 2016. PMID: 26728598 Free PMC article.
The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration.
Hartman ZR, Schaller MD, Agazie YM. Hartman ZR, et al. Mol Cancer Res. 2013 Jun;11(6):651-64. doi: 10.1158/1541-7786.MCR-12-0578. Epub 2013 Mar 19. Mol Cancer Res. 2013. PMID: 23512980 Free PMC article.
HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling.
Hartman Z, Zhao H, Agazie YM. Hartman Z, et al. Oncogene. 2013 Aug 29;32(35):4169-80. doi: 10.1038/onc.2012.418. Epub 2012 Oct 1. Oncogene. 2013. PMID: 23027125 Free PMC article.
The signaling and transformation potency of the overexpressed HER2 protein is dependent on the normally-expressed EGFR.
Zhou X, Agazie YM. Zhou X, et al. Cell Signal. 2012 Jan;24(1):140-50. doi: 10.1016/j.cellsig.2011.08.015. Epub 2011 Sep 3. Cell Signal. 2012. PMID: 21911055 Free PMC article.
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
Zhou XD, Agazie YM. Zhou XD, et al. Cell Death Differ. 2008 Jun;15(6):988-96. doi: 10.1038/cdd.2008.54. Epub 2008 Apr 18. Cell Death Differ. 2008. PMID: 18421299
SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis.
Zhou X, Coad J, Ducatman B, Agazie YM. Zhou X, et al. Histopathology. 2008 Oct;53(4):389-402. doi: 10.1111/j.1365-2559.2008.03103.x. Epub 2008 Jul 15. Histopathology. 2008. PMID: 18643929