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Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.
Hu M, Luo Q, Alitongbieke G, Chong S, Xu C, Xie L, Chen X, Zhang D, Zhou Y, Wang Z, Ye X, Cai L, Zhang F, Chen H, Jiang F, Fang H, Yang S, Liu J, Diaz-Meco MT, Su Y, Zhou H, Moscat J, Lin X, Zhang XK. Hu M, et al. Mol Cell. 2017 Apr 6;66(1):141-153.e6. doi: 10.1016/j.molcel.2017.03.008. Mol Cell. 2017. PMID: 28388439 Free PMC article.
Targeting truncated RXRα for cancer therapy.
Zhang X, Zhou H, Su Y. Zhang X, et al. Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):49-59. doi: 10.1093/abbs/gmv104. Epub 2015 Oct 21. Acta Biochim Biophys Sin (Shanghai). 2016. PMID: 26494413 Free PMC article. Review.
NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell.
Chen F, Chen J, Lin J, Cheltsov AV, Xu L, Chen Y, Zeng Z, Chen L, Huang M, Hu M, Ye X, Zhou Y, Wang G, Su Y, Zhang L, Zhou F, Zhang XK, Zhou H. Chen F, et al. Protein Cell. 2015 Sep;6(9):654-666. doi: 10.1007/s13238-015-0178-9. Epub 2015 Jul 9. Protein Cell. 2015. PMID: 26156677 Free PMC article.
Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.
Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y. Chen L, et al. Chem Biol. 2014 May 22;21(5):596-607. doi: 10.1016/j.chembiol.2014.02.017. Epub 2014 Apr 3. Chem Biol. 2014. PMID: 24704507 Free PMC article.