CA38192/CA/NCI NIH HHS/United States[Grant Number] - Search Results

Year	Number of Results
1989	1
1990	1
1994	1
1995	2
1996	2
1997	2
1998	2
1999	2
2021	0

1

2-ethynylnaphthalene as a mechanism-based inactivator of the cytochrome P-450 catalyzed N-oxidation of 2-naphthylamine.

Hammons GJ, Alworth WL, Hopkins NE, Guengerich FP, Kadlubar FF. Hammons GJ, et al. Chem Res Toxicol. 1989 Nov-Dec;2(6):367-74. doi: 10.1021/tx00012a003. Chem Res Toxicol. 1989. PMID: 2519725

2

Aryl acetylenes as mechanism-based inhibitors of cytochrome P450-dependent monooxygenase enzymes.

Foroozesh M, Primrose G, Guo Z, Bell LC, Alworth WL, Guengerich FP. Foroozesh M, et al. Chem Res Toxicol. 1997 Jan;10(1):91-102. doi: 10.1021/tx960064g. Chem Res Toxicol. 1997. PMID: 9074808

3

Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1.

Shimada T, Yamazaki H, Foroozesh M, Hopkins NE, Alworth WL, Guengerich FP. Shimada T, et al. Chem Res Toxicol. 1998 Sep;11(9):1048-56. doi: 10.1021/tx980090+. Chem Res Toxicol. 1998. PMID: 9760279

4

Inactivation of cytochrome P450s 2B1, 2B4, 2B6, and 2B11 by arylalkynes.

Roberts ES, Hopkins NE, Foroozesh M, Alworth WL, Halpert JR, Hollenberg PF. Roberts ES, et al. Drug Metab Dispos. 1997 Nov;25(11):1242-8. Drug Metab Dispos. 1997. PMID: 9351899 Clinical Trial.

5

Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity.

Alexander DL, Zhang L, Foroozesh M, Alworth WL, Jefcoate CR. Alexander DL, et al. Toxicol Appl Pharmacol. 1999 Dec 1;161(2):123-39. doi: 10.1006/taap.1999.8794. Toxicol Appl Pharmacol. 1999. PMID: 10581206

6

Mechanistic studies of 9-ethynylphenanthrene-inactivated cytochrome P450 2B1.

Roberts ES, Ballou DP, Hopkins NE, Alworth WL, Hollenberg PF. Roberts ES, et al. Arch Biochem Biophys. 1995 Nov 10;323(2):303-12. doi: 10.1006/abbi.1995.9960. Arch Biochem Biophys. 1995. PMID: 7487092

7

A role for threonine 302 in the mechanism-based inactivation of P450 2B4 by 2-ethynylnaphthalene.

Roberts ES, Pernecky SJ, Alworth WL, Hollenberg PF. Roberts ES, et al. Arch Biochem Biophys. 1996 Jul 15;331(2):170-6. doi: 10.1006/abbi.1996.0295. Arch Biochem Biophys. 1996. PMID: 8660695

8

Identification of selective mechanism-based inactivators of cytochromes P-450 2B4 and 2B5, and determination of the molecular basis for differential susceptibility.

Strobel SM, Szklarz GD, He Y, Foroozesh M, Alworth WL, Roberts ES, Hollenberg PF, Halpert JR. Strobel SM, et al. J Pharmacol Exp Ther. 1999 Jul;290(1):445-51. J Pharmacol Exp Ther. 1999. PMID: 10381811

9

Effects of 1-ethynylpyrene and related inhibitors of P450 isozymes upon benzo[a]pyrene metabolism by liver microsomes.

Hall M, Parker DK, Grover PL, Lu JY, Hopkins NE, Alworth WL. Hall M, et al. Chem Biol Interact. 1990;76(2):181-92. doi: 10.1016/0009-2797(90)90087-4. Chem Biol Interact. 1990. PMID: 2225228

10

Identification of active-site peptides from 3H-labeled 2-ethynylnaphthalene-inactivated P450 2B1 and 2B4 using amino acid sequencing and mass spectrometry.

Roberts ES, Hopkins NE, Zaluzec EJ, Gage DA, Alworth WL, Hollenberg PF. Roberts ES, et al. Biochemistry. 1994 Mar 29;33(12):3766-71. doi: 10.1021/bi00178a037. Biochemistry. 1994. PMID: 8142377

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