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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 2
2005 4
2006 2
2007 2
2008 3
2009 4
2010 2
2020 0
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20 results
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Page 1
Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element.
Hurley LH, Von Hoff DD, Siddiqui-Jain A, Yang D. Hurley LH, et al. Semin Oncol. 2006 Aug;33(4):498-512. doi: 10.1053/j.seminoncol.2006.04.012. Semin Oncol. 2006. PMID: 16890804 Review.
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions.
Qin Y, Hurley LH. Qin Y, et al. Biochimie. 2008 Aug;90(8):1149-71. doi: 10.1016/j.biochi.2008.02.020. Epub 2008 Feb 29. Biochimie. 2008. PMID: 18355457 Free PMC article. Review.
Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein.
González V, Guo K, Hurley L, Sun D. González V, et al. J Biol Chem. 2009 Aug 28;284(35):23622-35. doi: 10.1074/jbc.M109.018028. Epub 2009 Jul 6. J Biol Chem. 2009. PMID: 19581307 Free PMC article.
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.
Seenisamy J, Rezler EM, Powell TJ, Tye D, Gokhale V, Joshi CS, Siddiqui-Jain A, Hurley LH. Seenisamy J, et al. J Am Chem Soc. 2004 Jul 21;126(28):8702-9. doi: 10.1021/ja040022b. J Am Chem Soc. 2004. PMID: 15250722
The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.
Sun D, Hurley LH. Sun D, et al. J Med Chem. 2009 May 14;52(9):2863-74. doi: 10.1021/jm900055s. J Med Chem. 2009. PMID: 19385599 Free PMC article.
The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity.
González V, Hurley LH. González V, et al. Biochemistry. 2010 Nov 16;49(45):9706-14. doi: 10.1021/bi100509s. Epub 2010 Oct 21. Biochemistry. 2010. PMID: 20932061 Free PMC article.
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Seenisamy J, Bashyam S, Gokhale V, Vankayalapati H, Sun D, Siddiqui-Jain A, Streiner N, Shin-Ya K, White E, Wilson WD, Hurley LH. Seenisamy J, et al. J Am Chem Soc. 2005 Mar 9;127(9):2944-59. doi: 10.1021/ja0444482. J Am Chem Soc. 2005. PMID: 15740131
Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.
Dexheimer TS, Sun D, Hurley LH. Dexheimer TS, et al. J Am Chem Soc. 2006 Apr 26;128(16):5404-15. doi: 10.1021/ja0563861. J Am Chem Soc. 2006. PMID: 16620112 Free PMC article.
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.
Rezler EM, Seenisamy J, Bashyam S, Kim MY, White E, Wilson WD, Hurley LH. Rezler EM, et al. J Am Chem Soc. 2005 Jul 6;127(26):9439-47. doi: 10.1021/ja0505088. J Am Chem Soc. 2005. PMID: 15984871
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.
Grand CL, Powell TJ, Nagle RB, Bearss DJ, Tye D, Gleason-Guzman M, Hurley LH. Grand CL, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6140-5. doi: 10.1073/pnas.0400460101. Epub 2004 Apr 12. Proc Natl Acad Sci U S A. 2004. PMID: 15079086 Free PMC article. Retracted.
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