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110 results

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Page 1
CASZ1: Current Implications in Cardiovascular Diseases and Cancers.
Jian H, Poetsch A. Jian H, et al. Biomedicines. 2023 Jul 24;11(7):2079. doi: 10.3390/biomedicines11072079. Biomedicines. 2023. PMID: 37509718 Free PMC article. Review.
However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, whic …
However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at f …
CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity.
Yokota K, Shibata H, Kurihara I, Itoh H, Sone M. Yokota K, et al. Hypertens Res. 2023 Feb;46(2):417-420. doi: 10.1038/s41440-022-01131-8. Epub 2022 Dec 16. Hypertens Res. 2023. PMID: 36522424 Review.
Further, a recent study of GWAS on PA identified CASZ1 to be a PA-related gene and demonstrated that overexpression of CASZ1 suppresses aldosterone biosynthesis in adrenal cells. These results suggest CASZ1 plays a pivotal role in the pathophysiology of hyper …
Further, a recent study of GWAS on PA identified CASZ1 to be a PA-related gene and demonstrated that overexpression of CASZ1 s …
Role of the CASZ1 transcription factor in tissue development and disease.
Liu T, Li T, Ke S. Liu T, et al. Eur J Med Res. 2023 Dec 5;28(1):562. doi: 10.1186/s40001-023-01548-y. Eur J Med Res. 2023. PMID: 38053207 Free PMC article. Review.
Additionally, CASZ1 controls the transition between neurogenesis and gliomagenesis. During human cardiovascular system development, CASZ1 is essential for cardiomyocyte differentiation, cardiac morphogenesis, and vascular morphology homeostasis and formation. ... …
Additionally, CASZ1 controls the transition between neurogenesis and gliomagenesis. During human cardiovascular system development, …
CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.
Cardoso BA, Duque M, Gírio A, Fragoso R, Oliveira ML, Allen JR, Martins LR, Correia NC, Silveira AB, Veloso A, Kimura S, Demoen L, Matthijssens F, Jeha S, Cheng C, Pui CH, Grosso AR, Neto JL, De Almeida SF, Van Vlieberghe P, Mullighan CG, Yunes JA, Langenau DM, Pflumio F, Barata JT. Cardoso BA, et al. Haematologica. 2024 Jun 1;109(6):1713-1725. doi: 10.3324/haematol.2023.282854. Haematologica. 2024. PMID: 38058200 Free PMC article.
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 has been implicated in cancer, either suppressing or promoting tumor development depending on the tissue. ...
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 …
Epigenetic modification of Castor zinc finger 1 (CASZ1) is associated with tumor microenvironments and prognosis of clear cell renal cell carcinoma.
Li F, Liang J, Wei X. Li F, et al. Int J Surg. 2024 Sep 4. doi: 10.1097/JS9.0000000000002070. Online ahead of print. Int J Surg. 2024. PMID: 39235847
The involvement of the Castor zinc finger 1 (CASZ1) gene in adverse prognostic outcomes has been observed across different cancer types. ...Diminished CASZ1 mRNA levels were notably correlated with heightened cytosine-phosphate-guanine (CpG) methylation , indicating …
The involvement of the Castor zinc finger 1 (CASZ1) gene in adverse prognostic outcomes has been observed across different cancer typ …
CASZ1 Is Essential for Skin Epidermal Terminal Differentiation.
Droll SH, Zhang BJ, Levine MC, Xue C, Ho PJ, Bao X. Droll SH, et al. J Invest Dermatol. 2024 Sep;144(9):2029-2038. doi: 10.1016/j.jid.2024.02.014. Epub 2024 Mar 6. J Invest Dermatol. 2024. PMID: 38458428 Free PMC article.
CASZ1 expression is upregulated during epidermal terminal differentiation. In addition, CASZ1 expression is impaired in several skin disorders with impaired barrier function, such as atopic dermatitis, psoriasis, and squamous cell carcinoma. ...Taken together, our f …
CASZ1 expression is upregulated during epidermal terminal differentiation. In addition, CASZ1 expression is impaired in severa …
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T, Hoekzema K, Vecchio D, Wu H, Sulovari A, Coe BP, Gillentine MA, Wilfert AB, Perez-Jurado LA, Kvarnung M, Sleyp Y, Earl RK, Rosenfeld JA, Geisheker MR, Han L, Du B, Barnett C, Thompson E, Shaw M, Carroll R, Friend K, Catford R, Palmer EE, Zou X, Ou J, Li H, Guo H, Gerdts J, Avola E, Calabrese G, Elia M, Greco D, Lindstrand A, Nordgren A, Anderlid BM, Vandeweyer G, Van Dijck A, Van der Aa N, McKenna B, Hancarova M, Bendova S, Havlovicova M, Malerba G, Bernardina BD, Muglia P, van Haeringen A, Hoffer MJV, Franke B, Cappuccio G, Delatycki M, Lockhart PJ, Manning MA, Liu P, Scheffer IE, Brunetti-Pierri N, Rommelse N, Amaral DG, Santen GWE, Trabetti E, Sedláček Z, Michaelson JJ, Pierce K, Courchesne E, Kooy RF; SPARK Consortium; Nordenskjöld M, Romano C, Peeters H, Bernier RA, Gecz J, Xia K, Eichler EE. Wang T, et al. Nat Commun. 2020 Oct 1;11(1):4932. doi: 10.1038/s41467-020-18723-y. Nat Commun. 2020. PMID: 33004838 Free PMC article.

We identify 90 genes enriched for DNMs (FDR 5%; e.g., GABRG2 and UIMC1); of which, 61 reach FWER significance (p < 3.64E-07; e.g., CASZ1). In addition to doubling the number of patients for many NDD risk genes, we present phenotype-genotype correlations for seven risk g

…

We identify 90 genes enriched for DNMs (FDR 5%; e.g., GABRG2 and UIMC1); of which, 61 reach FWER significance (p < 3.64E-07; e.g., CAS

…
Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells.
Mao C, Huang C, Hu Z, Qu S. Mao C, et al. MedComm (2020). 2022 Oct 20;3(4):e182. doi: 10.1002/mco2.182. eCollection 2022 Dec. MedComm (2020). 2022. PMID: 36276925 Free PMC article.
Knockdown of CASZ1 inhibited proliferation and invasion in vitro, whereas upregulation of CASZ1 presented opposite results. Overexpression of CASZ1 increased transcriptional process of target gene p75NTR. CASZ1 was the potential transcriptional regulat …
Knockdown of CASZ1 inhibited proliferation and invasion in vitro, whereas upregulation of CASZ1 presented opposite results. Ov …
CASZ1 promotes migration, invasion, and metastasis of lung cancer cells by controlling expression of ITGAV.
Taheri Baghmisheh S, Wu YY, Wu JE, Hsu KF, Chen YL, Hong TM. Taheri Baghmisheh S, et al. Am J Cancer Res. 2023 Jan 15;13(1):176-189. eCollection 2023. Am J Cancer Res. 2023. PMID: 36777515 Free PMC article.
The results of an RNA-sequencing analysis of CASZ1-silenced cells showed that CASZ1 considerably affected the integrin-mediated pathways. CASZ1 bound to the ITGAV promoter and transcriptionally regulated ITGAV expression. Our findings demonstrate that CASZ …
The results of an RNA-sequencing analysis of CASZ1-silenced cells showed that CASZ1 considerably affected the integrin-mediate …
A Casz1-NuRD complex regulates temporal identity transitions in neural progenitors.
Mattar P, Jolicoeur C, Dang T, Shah S, Clark BS, Cayouette M. Mattar P, et al. Sci Rep. 2021 Feb 16;11(1):3858. doi: 10.1038/s41598-021-83395-7. Sci Rep. 2021. PMID: 33594190 Free PMC article.
A number of temporal identity factors that control these transitions in progenitor competence have been identified, but the molecular mechanisms underlying their function remain unclear. Here, we asked how Casz1, the mammalian orthologue of Drosophila castor, regulates com …
A number of temporal identity factors that control these transitions in progenitor competence have been identified, but the molecular mechan …
110 results