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2006 1
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126 results

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Page 1
Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival.
Sun Y, Ren M, Zhang Y, Li S, Luo Z, Sun S, He S, Wang G, Zhang D, Mansour SL, Song L, Liu Z. Sun Y, et al. Science. 2025 Apr 18;388(6744):eado4930. doi: 10.1126/science.ado4930. Epub 2025 Apr 18. Science. 2025. PMID: 39883789
Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production. However, long-term OHC survival was compromised in Casz1 mutant mice. In addition, the transcription factor Gata3 was down-regulated in Casz1-deleted IHCs, and …
Loss of Casz1 resulted in transdifferentiation of IHCs into OHCs, without affecting OHC production. However, long-term OHC survival w …
Epigenetic modification of Castor zinc finger 1 (CASZ1) is associated with tumor microenvironments and prognosis of clear cell renal cell carcinoma.
Li F, Liang J, Wei X. Li F, et al. Int J Surg. 2025 Jan 1;111(1):988-997. doi: 10.1097/JS9.0000000000002070. Int J Surg. 2025. PMID: 39235847 Free PMC article.
The involvement of the Castor zinc finger 1 (CASZ1) gene in adverse prognostic outcomes has been observed across different cancer types. ...Diminished CASZ1 mRNA levels were notably correlated with heightened cytosine-phosphate-guanine (CpG) methylation, indicating …
The involvement of the Castor zinc finger 1 (CASZ1) gene in adverse prognostic outcomes has been observed across different cancer typ …
Role of the CASZ1 transcription factor in tissue development and disease.
Liu T, Li T, Ke S. Liu T, et al. Eur J Med Res. 2023 Dec 5;28(1):562. doi: 10.1186/s40001-023-01548-y. Eur J Med Res. 2023. PMID: 38053207 Free PMC article. Review.
Additionally, CASZ1 controls the transition between neurogenesis and gliomagenesis. During human cardiovascular system development, CASZ1 is essential for cardiomyocyte differentiation, cardiac morphogenesis, and vascular morphology homeostasis and formation. ... …
Additionally, CASZ1 controls the transition between neurogenesis and gliomagenesis. During human cardiovascular system development, …
CASZ1: Current Implications in Cardiovascular Diseases and Cancers.
Jian H, Poetsch A. Jian H, et al. Biomedicines. 2023 Jul 24;11(7):2079. doi: 10.3390/biomedicines11072079. Biomedicines. 2023. PMID: 37509718 Free PMC article. Review.
However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, whic …
However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at f …
CASZ1: a promising factor modulating aldosterone biosynthesis and mineralocorticoid receptor activity.
Yokota K, Shibata H, Kurihara I, Itoh H, Sone M. Yokota K, et al. Hypertens Res. 2023 Feb;46(2):417-420. doi: 10.1038/s41440-022-01131-8. Epub 2022 Dec 16. Hypertens Res. 2023. PMID: 36522424 Review.
Further, a recent study of GWAS on PA identified CASZ1 to be a PA-related gene and demonstrated that overexpression of CASZ1 suppresses aldosterone biosynthesis in adrenal cells. These results suggest CASZ1 plays a pivotal role in the pathophysiology of hyper …
Further, a recent study of GWAS on PA identified CASZ1 to be a PA-related gene and demonstrated that overexpression of CASZ1 s …
CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia.
Cardoso BA, Duque M, Gírio A, Fragoso R, Oliveira ML, Allen JR, Martins LR, Correia NC, Silveira AB, Veloso A, Kimura S, Demoen L, Matthijssens F, Jeha S, Cheng C, Pui CH, Grosso AR, Neto JL, De Almeida SF, Van Vlieberghe P, Mullighan CG, Yunes JA, Langenau DM, Pflumio F, Barata JT. Cardoso BA, et al. Haematologica. 2024 Jun 1;109(6):1713-1725. doi: 10.3324/haematol.2023.282854. Haematologica. 2024. PMID: 38058200 Free PMC article.
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 has been implicated in cancer, either suppressing or promoting tumor development depending on the tissue. ...
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 …
CASZ1 Regulates Late Epidermal Differentiation.
Oss-Ronen L, Tickotsky Moskovitz N, Levi H, Levin L, Cohen I. Oss-Ronen L, et al. J Invest Dermatol. 2024 Nov;144(11):2593-2595.e4. doi: 10.1016/j.jid.2024.04.007. Epub 2024 May 17. J Invest Dermatol. 2024. PMID: 38763175 Free article. No abstract available.
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T, Hoekzema K, Vecchio D, Wu H, Sulovari A, Coe BP, Gillentine MA, Wilfert AB, Perez-Jurado LA, Kvarnung M, Sleyp Y, Earl RK, Rosenfeld JA, Geisheker MR, Han L, Du B, Barnett C, Thompson E, Shaw M, Carroll R, Friend K, Catford R, Palmer EE, Zou X, Ou J, Li H, Guo H, Gerdts J, Avola E, Calabrese G, Elia M, Greco D, Lindstrand A, Nordgren A, Anderlid BM, Vandeweyer G, Van Dijck A, Van der Aa N, McKenna B, Hancarova M, Bendova S, Havlovicova M, Malerba G, Bernardina BD, Muglia P, van Haeringen A, Hoffer MJV, Franke B, Cappuccio G, Delatycki M, Lockhart PJ, Manning MA, Liu P, Scheffer IE, Brunetti-Pierri N, Rommelse N, Amaral DG, Santen GWE, Trabetti E, Sedláček Z, Michaelson JJ, Pierce K, Courchesne E, Kooy RF; SPARK Consortium; Nordenskjöld M, Romano C, Peeters H, Bernier RA, Gecz J, Xia K, Eichler EE. Wang T, et al. Nat Commun. 2020 Oct 1;11(1):4932. doi: 10.1038/s41467-020-18723-y. Nat Commun. 2020. PMID: 33004838 Free PMC article.

We identify 90 genes enriched for DNMs (FDR 5%; e.g., GABRG2 and UIMC1); of which, 61 reach FWER significance (p < 3.64E-07; e.g., CASZ1). In addition to doubling the number of patients for many NDD risk genes, we present phenotype-genotype correlations for seven risk g

…

We identify 90 genes enriched for DNMs (FDR 5%; e.g., GABRG2 and UIMC1); of which, 61 reach FWER significance (p < 3.64E-07; e.g., CAS

…
CASZ1 Is Essential for Skin Epidermal Terminal Differentiation.
Droll SH, Zhang BJ, Levine MC, Xue C, Ho PJ, Bao X. Droll SH, et al. J Invest Dermatol. 2024 Sep;144(9):2029-2038. doi: 10.1016/j.jid.2024.02.014. Epub 2024 Mar 6. J Invest Dermatol. 2024. PMID: 38458428 Free PMC article.
CASZ1 expression is upregulated during epidermal terminal differentiation. In addition, CASZ1 expression is impaired in several skin disorders with impaired barrier function, such as atopic dermatitis, psoriasis, and squamous cell carcinoma. ...Taken together, our f …
CASZ1 expression is upregulated during epidermal terminal differentiation. In addition, CASZ1 expression is impaired in severa …
Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry.
Liu Z, Zhang X, Xu M, Lei H, Shern JF, Thiele CJ. Liu Z, et al. Cell Death Dis. 2022 Oct 15;13(10):871. doi: 10.1038/s41419-022-05314-6. Cell Death Dis. 2022. PMID: 36243768 Free PMC article.
Oncogenic subversion of CRC TFs is well documented, but the role of loss of tumor suppressors plays remains unclear. Zinc-finger TF CASZ1 is a chromosome 1p36 (chr1p36) tumor suppressor. Single-cell RNA sequencing data analyses indicate that CASZ1 is highly expresse …
Oncogenic subversion of CRC TFs is well documented, but the role of loss of tumor suppressors plays remains unclear. Zinc-finger TF CASZ1 …
126 results