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Year Number of Results
1984 1
1985 1
1986 2
1988 1
1991 1
1992 2
1994 3
1995 28
1996 39
1997 55
1998 101
1999 144
2000 148
2001 204
2002 214
2003 285
2004 342
2005 452
2006 520
2007 670
2008 737
2009 656
2010 714
2011 666
2012 688
2013 601
2014 570
2015 600
2016 582
2017 558
2018 494
2019 518
2020 531
2021 490
2022 418
2023 334
2024 357
2025 169

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11,131 results

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Page 1
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.
Pertwee RG. Pertwee RG. Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10. Br J Pharmacol. 2008. PMID: 17828291 Free PMC article. Review.
Delta9-THCV behaves as a potent CB2 receptor partial agonist in vitro. In contrast, it antagonizes cannabinoid receptor agonists in CB1-expressing tissues. This it does with relatively high potency and in a manner that is both tissue and ligand depende …
Delta9-THCV behaves as a potent CB2 receptor partial agonist in vitro. In contrast, it antagonizes cannabinoid receptor …
The CB1 Receptor as the Cornerstone of Exostasis.
Piazza PV, Cota D, Marsicano G. Piazza PV, et al. Neuron. 2017 Mar 22;93(6):1252-1274. doi: 10.1016/j.neuron.2017.02.002. Neuron. 2017. PMID: 28334603 Free article. Review.
The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in most brain and body functions. ...We propose here a possible unifying theory of CB1 receptor functions that can be tested by fut …
The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in mo …
Structural Insights into CB1 Receptor Biased Signaling.
Al-Zoubi R, Morales P, Reggio PH. Al-Zoubi R, et al. Int J Mol Sci. 2019 Apr 13;20(8):1837. doi: 10.3390/ijms20081837. Int J Mol Sci. 2019. PMID: 31013934 Free PMC article. Review.
CB1 receptor ligands have been shown to induce a complex pattern of intracellular effects. ...This review will focus on the structural features of the CB1 receptor, mutations known to bias its signaling, and reported studies of CB1 receptor …
CB1 receptor ligands have been shown to induce a complex pattern of intracellular effects. ...This review will focus on the st …
Stress regulates endocannabinoid-CB1 receptor signaling.
Hillard CJ. Hillard CJ. Semin Immunol. 2014 Oct;26(5):380-8. doi: 10.1016/j.smim.2014.04.001. Epub 2014 May 29. Semin Immunol. 2014. PMID: 24882055 Free PMC article. Review.
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. ...On the other hand, repeated exposure to the same stress can sensitize CB1 receptor signaling, resulting in dampening of the str …
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. ...O …
CB1 cannabinoid receptor ligands.
Thakur GA, Nikas SP, Makriyannis A. Thakur GA, et al. Mini Rev Med Chem. 2005 Jul;5(7):631-40. doi: 10.2174/1389557054368772. Mini Rev Med Chem. 2005. PMID: 16026309 Review.
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications. ...T …
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and ha …
CB1 receptor-deficient mice as a model for depression.
Valverde O, Torrens M. Valverde O, et al. Neuroscience. 2012 Mar 1;204:193-206. doi: 10.1016/j.neuroscience.2011.09.031. Epub 2011 Sep 19. Neuroscience. 2012. PMID: 21964469 Review.
Considering the body of elements that acts under the control of the endocannabinoid system and the key role played by the activation of the CB1 cannabinoid receptors in the control of emotion and mood, we had proposed that genetically modified mice lacking the CB …
Considering the body of elements that acts under the control of the endocannabinoid system and the key role played by the activation of the …
Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling.
Walsh KB, Andersen HK. Walsh KB, et al. Int J Mol Sci. 2020 Aug 25;21(17):6115. doi: 10.3390/ijms21176115. Int J Mol Sci. 2020. PMID: 32854313 Free PMC article. Review.
In addition to their desirable euphoric and antinociceptive effects, SCs can cause severe toxicity including seizures, respiratory depression, cardiac arrhythmias, stroke and psychosis. Binding of SCs to the CB1 receptor, expressed in the central and peripheral nerv …
In addition to their desirable euphoric and antinociceptive effects, SCs can cause severe toxicity including seizures, respiratory depressio …
Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.
Nguyen T, Li JX, Thomas BF, Wiley JL, Kenakin TP, Zhang Y. Nguyen T, et al. Med Res Rev. 2017 May;37(3):441-474. doi: 10.1002/med.21418. Epub 2016 Nov 23. Med Res Rev. 2017. PMID: 27879006 Free PMC article. Review.
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological processes and physiological functions. ...In 2005, it was discovered that the CB1 receptor contains allosteric site(s) that can be …
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological proc …
CB1 receptor antagonists: new discoveries leading to new perspectives.
Kirilly E, Gonda X, Bagdy G. Kirilly E, et al. Acta Physiol (Oxf). 2012 May;205(1):41-60. doi: 10.1111/j.1748-1716.2012.02402.x. Acta Physiol (Oxf). 2012. PMID: 22463610 Review.
CB(1) receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be effective as therapeutic agents for obesity and related cardiometabolic problems; however, use of rimonabant, the first marketed CB(1) recep …
CB(1) receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be eff …
Efficacy in CB1 receptor-mediated signal transduction.
Howlett AC. Howlett AC. Br J Pharmacol. 2004 Aug;142(8):1209-18. doi: 10.1038/sj.bjp.0705881. Br J Pharmacol. 2004. PMID: 15308578 Free PMC article. Review.
CB(1) receptor cellular signal transduction is dependent on the expression of G proteins to which the receptor couples, the potential for precoupling of particular G proteins to the receptors either by scaffolding mechanisms or colocalization in lipid raft domains, …
CB(1) receptor cellular signal transduction is dependent on the expression of G proteins to which the receptor couples, the po …
11,131 results
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