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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1985 1
1986 2
1988 1
1991 1
1992 2
1994 3
1995 28
1996 39
1997 55
1998 101
1999 144
2000 148
2001 204
2002 214
2003 285
2004 342
2005 452
2006 520
2007 670
2008 737
2009 656
2010 714
2011 666
2012 688
2013 601
2014 570
2015 600
2016 582
2017 558
2018 494
2019 518
2020 531
2021 488
2022 418
2023 334
2024 194

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10,853 results

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Page 1
The CB1 Receptor as the Cornerstone of Exostasis.
Piazza PV, Cota D, Marsicano G. Piazza PV, et al. Neuron. 2017 Mar 22;93(6):1252-1274. doi: 10.1016/j.neuron.2017.02.002. Neuron. 2017. PMID: 28334603 Free article. Review.
The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in most brain and body functions. In this Perspective, we provide evidence indicating that CB1 receptor functions are key determina …
The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in mo …
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.
Pertwee RG. Pertwee RG. Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10. Br J Pharmacol. 2008. PMID: 17828291 Free PMC article. Review.
Delta9-THCV behaves as a potent CB2 receptor partial agonist in vitro. In contrast, it antagonizes cannabinoid receptor agonists in CB1-expressing tissues. This it does with relatively high potency and in a manner that is both tissue and ligand depende …
Delta9-THCV behaves as a potent CB2 receptor partial agonist in vitro. In contrast, it antagonizes cannabinoid receptor
Structural Insights into CB1 Receptor Biased Signaling.
Al-Zoubi R, Morales P, Reggio PH. Al-Zoubi R, et al. Int J Mol Sci. 2019 Apr 13;20(8):1837. doi: 10.3390/ijms20081837. Int J Mol Sci. 2019. PMID: 31013934 Free PMC article. Review.
CB1 receptor ligands have been shown to induce a complex pattern of intracellular effects. ...These proteins can mediate receptor desensitization, trafficking, or signaling. Ligand specificity and selectivity, complex cellular components, and the concomitant
CB1 receptor ligands have been shown to induce a complex pattern of intracellular effects. ...These proteins can mediate re
CB1 cannabinoid receptor ligands.
Thakur GA, Nikas SP, Makriyannis A. Thakur GA, et al. Mini Rev Med Chem. 2005 Jul;5(7):631-40. doi: 10.2174/1389557054368772. Mini Rev Med Chem. 2005. PMID: 16026309 Review.
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications. ...T …
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and ha …
Stress regulates endocannabinoid-CB1 receptor signaling.
Hillard CJ. Hillard CJ. Semin Immunol. 2014 Oct;26(5):380-8. doi: 10.1016/j.smim.2014.04.001. Epub 2014 May 29. Semin Immunol. 2014. PMID: 24882055 Free PMC article. Review.
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. ...Data are reviewed that support the hypothesis that CB1 receptor signaling is stress responsive and that maintaining robust endo …
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. ...D …
CB1 receptor-deficient mice as a model for depression.
Valverde O, Torrens M. Valverde O, et al. Neuroscience. 2012 Mar 1;204:193-206. doi: 10.1016/j.neuroscience.2011.09.031. Epub 2011 Sep 19. Neuroscience. 2012. PMID: 21964469 Review.
In this review, we have integrated most of the study that have been developed using mice lacking CB1 cannabinoid receptor for the studies of emotional responses. ...Finally, clinical studies support and confirm the obtained findings in animal models and lead …
In this review, we have integrated most of the study that have been developed using mice lacking CB1 cannabinoid receptor
Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.
Nguyen T, Li JX, Thomas BF, Wiley JL, Kenakin TP, Zhang Y. Nguyen T, et al. Med Res Rev. 2017 May;37(3):441-474. doi: 10.1002/med.21418. Epub 2016 Nov 23. Med Res Rev. 2017. PMID: 27879006 Free PMC article. Review.
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological processes and physiological functions. ...In 2005, it was discovered that the CB1 receptor contains allosteric site(s) that can be …
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological proc …
Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling.
Walsh KB, Andersen HK. Walsh KB, et al. Int J Mol Sci. 2020 Aug 25;21(17):6115. doi: 10.3390/ijms21176115. Int J Mol Sci. 2020. PMID: 32854313 Free PMC article. Review.
In addition to their desirable euphoric and antinociceptive effects, SCs can cause severe toxicity including seizures, respiratory depression, cardiac arrhythmias, stroke and psychosis. Binding of SCs to the CB1 receptor, expressed in the central and peripheral nerv …
In addition to their desirable euphoric and antinociceptive effects, SCs can cause severe toxicity including seizures, respiratory depressio …
CB1 receptor antagonists: new discoveries leading to new perspectives.
Kirilly E, Gonda X, Bagdy G. Kirilly E, et al. Acta Physiol (Oxf). 2012 May;205(1):41-60. doi: 10.1111/j.1748-1716.2012.02402.x. Acta Physiol (Oxf). 2012. PMID: 22463610 Review.
CB(1) receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be effective as therapeutic agents for obesity and related cardiometabolic problems; however, use of rimonabant, the first marketed CB(1) recep
CB(1) receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be eff …
CB1 receptor antagonists for the treatment of nicotine addiction.
Cohen C, Kodas E, Griebel G. Cohen C, et al. Pharmacol Biochem Behav. 2005 Jun;81(2):387-95. doi: 10.1016/j.pbb.2005.01.024. Pharmacol Biochem Behav. 2005. PMID: 15935455 Review.
The CB1 receptor plays a key role in this interaction. CB1 knockout mice are less sensitive to the motivational effects of nicotine although this depends on the experimental model. The selective CB1 antagonist, rimonabant (SR141716), reduces nicotine s …
The CB1 receptor plays a key role in this interaction. CB1 knockout mice are less sensitive to the motivational effects …
10,853 results
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