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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1985 1
1986 2
1988 1
1991 1
1992 2
1994 3
1995 28
1996 39
1997 55
1998 101
1999 144
2000 148
2001 204
2002 214
2003 285
2004 342
2005 452
2006 520
2007 670
2008 737
2009 656
2010 714
2011 666
2012 688
2013 600
2014 568
2015 600
2016 581
2017 558
2018 490
2019 512
2020 462
2021 100
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9,637 results
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Page 1
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.
Pertwee RG. Pertwee RG. Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10. Br J Pharmacol. 2008. PMID: 17828291 Free PMC article. Review.
Delta9-THCV behaves as a potent CB2 receptor partial agonist in vitro. In contrast, it antagonizes cannabinoid receptor agonists in CB1-expressing tissues. This it does with relatively high potency and in a manner that is both tissue and ligand depende …
Delta9-THCV behaves as a potent CB2 receptor partial agonist in vitro. In contrast, it antagonizes cannabinoid receptor
Structural Insights into CB1 Receptor Biased Signaling.
Al-Zoubi R, Morales P, Reggio PH. Al-Zoubi R, et al. Int J Mol Sci. 2019 Apr 13;20(8):1837. doi: 10.3390/ijms20081837. Int J Mol Sci. 2019. PMID: 31013934 Free PMC article. Review.
CB1 receptor ligands have been shown to induce a complex pattern of intracellular effects. ...These proteins can mediate receptor desensitization, trafficking, or signaling. Ligand specificity and selectivity, complex cellular components, and the concomitant
CB1 receptor ligands have been shown to induce a complex pattern of intracellular effects. ...These proteins can mediate re
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor.
Shao Z, Yan W, Chapman K, Ramesh K, Ferrell AJ, Yin J, Wang X, Xu Q, Rosenbaum DM. Shao Z, et al. Nat Chem Biol. 2019 Dec;15(12):1199-1205. doi: 10.1038/s41589-019-0387-2. Epub 2019 Oct 28. Nat Chem Biol. 2019. PMID: 31659318
The CB1 receptor mediates the central nervous system response to cannabinoids, and is a drug target for pain, anxiety and seizures. CB1 also responds to allosteric modulators, which influence cannabinoid binding and efficacy. ...
The CB1 receptor mediates the central nervous system response to cannabinoids, and is a drug target for pain, anxiety and seiz …
Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling.
Walsh KB, Andersen HK. Walsh KB, et al. Int J Mol Sci. 2020 Aug 25;21(17):6115. doi: 10.3390/ijms21176115. Int J Mol Sci. 2020. PMID: 32854313 Free PMC article. Review.
Synthetic cannabinoids (SCs) are a class of new psychoactive substances (NPSs) that exhibit high affinity binding to the cannabinoid CB1 and CB2 receptors and display a pharmacological profile similar to the phytocannabinoid (-)-trans-delta(9)-tetrahydrocannabinol ( …
Synthetic cannabinoids (SCs) are a class of new psychoactive substances (NPSs) that exhibit high affinity binding to the cannabinoid
CB1 cannabinoid receptor ligands.
Thakur GA, Nikas SP, Makriyannis A. Thakur GA, et al. Mini Rev Med Chem. 2005 Jul;5(7):631-40. doi: 10.2174/1389557054368772. Mini Rev Med Chem. 2005. PMID: 16026309 Review.
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications. ...T …
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and ha …
CB1 receptor-mediated respiratory depression by endocannabinoids.
Iring A, Hricisák L, Benyó Z. Iring A, et al. Respir Physiol Neurobiol. 2017 Jun;240:48-52. doi: 10.1016/j.resp.2017.02.011. Epub 2017 Feb 22. Respir Physiol Neurobiol. 2017. PMID: 28254562
Endocannabinoids (ECs) are bioactive lipid mediators acting on two distinct cannabinoid receptors (CB1 and CB2), which are ubiquitously expressed in many tissues including the respiratory system. ...In contrast, CB1 knock-out mice showed no alteration in any …
Endocannabinoids (ECs) are bioactive lipid mediators acting on two distinct cannabinoid receptors (CB1 and CB2), which are ubi …
CB1 receptor-deficient mice as a model for depression.
Valverde O, Torrens M. Valverde O, et al. Neuroscience. 2012 Mar 1;204:193-206. doi: 10.1016/j.neuroscience.2011.09.031. Epub 2011 Sep 19. Neuroscience. 2012. PMID: 21964469 Review.
In this review, we have integrated most of the study that have been developed using mice lacking CB1 cannabinoid receptor for the studies of emotional responses. ...Finally, clinical studies support and confirm the obtained findings in animal models and lead …
In this review, we have integrated most of the study that have been developed using mice lacking CB1 cannabinoid receptor
Stress regulates endocannabinoid-CB1 receptor signaling.
Hillard CJ. Hillard CJ. Semin Immunol. 2014 Oct;26(5):380-8. doi: 10.1016/j.smim.2014.04.001. Epub 2014 May 29. Semin Immunol. 2014. PMID: 24882055 Free PMC article. Review.
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. ...Data are reviewed that support the hypothesis that CB1 receptor signaling is stress responsive and that maintaining robust endo …
The CB1 cannabinoid receptor is a G protein coupled receptor that is widely expressed throughout the brain. ...D …
Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor.
Nguyen T, Li JX, Thomas BF, Wiley JL, Kenakin TP, Zhang Y. Nguyen T, et al. Med Res Rev. 2017 May;37(3):441-474. doi: 10.1002/med.21418. Epub 2016 Nov 23. Med Res Rev. 2017. PMID: 27879006 Free PMC article. Review.
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological processes and physiological functions. ...In 2005, it was discovered that the CB1 receptor contains allosteric site(s) that can be …
The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role in many biological proc …
Overcoming the Psychiatric Side Effects of the Cannabinoid CB1 Receptor Antagonists: Current Approaches for Therapeutics Development.
Nguyen T, Thomas BF, Zhang Y. Nguyen T, et al. Curr Top Med Chem. 2019;19(16):1418-1435. doi: 10.2174/1568026619666190708164841. Curr Top Med Chem. 2019. PMID: 31284863 Free PMC article. Review.
The Cannabinoid CB1 Receptor (CB1R) is involved in a variety of physiological pathways and has long been considered a golden target for therapeutic manipulation. ...
The Cannabinoid CB1 Receptor (CB1R) is involved in a variety of physiological pathways and has long been considered a g …
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