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78 results

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Page 1
OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6.
Zhao Y, Ruan J, Li Z, Su X, Chen K, Lin Y, Cai Y, Wang P, Liu B, Schlüter D, Liang G, Wang X. Zhao Y, et al. Clin Transl Med. 2023 Aug;13(8):e1385. doi: 10.1002/ctm2.1385. Clin Transl Med. 2023. PMID: 37608493 Free PMC article.
Supplementation of CCN6 abolished the effect of OTUB1 deletion on breast cancer. Importantly, OTUB1 expression was downregulated in human breast cancer and positively correlated with CCN6 levels. CONCLUSION: This study identified OTUB1 as a novel regul …
Supplementation of CCN6 abolished the effect of OTUB1 deletion on breast cancer. Importantly, OTUB1 expression was downregulat …
CCN6: a modulator of breast cancer progression.
Leask A. Leask A. J Cell Commun Signal. 2016 Jun;10(2):163-4. doi: 10.1007/s12079-016-0321-2. Epub 2016 Apr 16. J Cell Commun Signal. 2016. PMID: 27086280 Free PMC article. Review.
In prior reports, the Kleer laboratory and colleagues have linked reduced expression of CCN6 (WISP3) with aggressive breast cancers. Loss of CCN6 was associated with elevated Akt phosphorylation and TAK1 activation. ...These results are consistent with the hy …
In prior reports, the Kleer laboratory and colleagues have linked reduced expression of CCN6 (WISP3) with aggressive breast cancer
CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/beta-Catenin Signaling to Inhibit EZH2-Driven EMT.
Gonzalez ME, Brophy B, Eido A, Leonetti AE, Djomehri SI, Augimeri G, Carruthers NJ, Cavalcante RG, Giordano F, Andò S, Nesvizhskii AI, Fearon ER, Kleer CG. Gonzalez ME, et al. Cancer Res. 2024 Oct 1;84(19):3235-3249. doi: 10.1158/0008-5472.CAN-23-4054. Cancer Res. 2024. PMID: 39024552 Free PMC article.
Inactivation of the tumor suppressor gene cellular communication network factor 6 (CCN6; also known as Wnt1-induced secreted protein 3) is a feature of mBrCAs, and mice with conditional inactivation of Ccn6 in mammary epithelium (Ccn6-KO) develop spindle mBrC …
Inactivation of the tumor suppressor gene cellular communication network factor 6 (CCN6; also known as Wnt1-induced secreted protein …
CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer.
Kleer CG, Zhang Y, Merajver SD. Kleer CG, et al. Cells Tissues Organs. 2007;185(1-3):95-9. doi: 10.1159/000101308. Cells Tissues Organs. 2007. PMID: 17587813 Review.
We found that CCN6 mRNA is reduced in 80% of cases of the most lethal form of locally advanced breast cancer, inflammatory breast cancer. ...CCN6 has tumor growth-, proliferation-, and invasion-inhibitory functions in breast cancer. ...
We found that CCN6 mRNA is reduced in 80% of cases of the most lethal form of locally advanced breast cancer, inflammatory bre …
Dual roles of cellular communication network factor 6 (CCN6) in the invasion and metastasis of oral cancer cells to bone via binding to BMP2 and RANKL.
Hochi H, Kubota S, Takigawa M, Nishida T. Hochi H, et al. Carcinogenesis. 2023 Dec 2;44(8-9):695-707. doi: 10.1093/carcin/bgad057. Carcinogenesis. 2023. PMID: 37590989 Free PMC article.
Furthermore, CCN6 combined with BMP2 suppressed EMT. These results suggest that CCN6 strongly suppresses EMT in cooperation with BMP2 and TGF-beta. ...Additionally, CCN6 interacted with RANKL, and CCN6 combined with RANKL suppressed RANKL-induced osteo …
Furthermore, CCN6 combined with BMP2 suppressed EMT. These results suggest that CCN6 strongly suppresses EMT in cooperation wi …
The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells.
Huang W, Martin EE, Burman B, Gonzalez ME, Kleer CG. Huang W, et al. Oncotarget. 2016 May 3;7(18):25180-93. doi: 10.18632/oncotarget.7734. Oncotarget. 2016. PMID: 26933820 Free PMC article.
CCN6 exerts breast cancer growth and invasion inhibitory functions, but the mechanisms remain to be defined. ...The relevance of these data to human breast cancer is highlighted by the finding that CCN6 protein levels are inversely correlated with Notc
CCN6 exerts breast cancer growth and invasion inhibitory functions, but the mechanisms remain to be defined. ...The relevance
Matricellular CCN6 (WISP3) protein: a tumor suppressor for mammary metaplastic carcinomas.
Tran MN, Kleer CG. Tran MN, et al. J Cell Commun Signal. 2018 Mar;12(1):13-19. doi: 10.1007/s12079-018-0451-9. Epub 2018 Jan 22. J Cell Commun Signal. 2018. PMID: 29357008 Free PMC article. Review.
Studies using human breast cancer tissue samples demonstrated that CCN6 messenger RNA and protein are expressed in normal breast epithelia but reduced or lost in aggressive breast cancer phenotypes, especially inflammatory breast cancer and metaplastic …
Studies using human breast cancer tissue samples demonstrated that CCN6 messenger RNA and protein are expressed in normal brea …
Effects of CCN6 overexpression on the cell motility and activation of p38/bone morphogenetic protein signaling pathways in pancreatic cancer cells.
Nam MW, Lee HK, Kim CW, Choi Y, Ahn D, Go RE, Choi KC. Nam MW, et al. Biomed Pharmacother. 2023 Jul;163:114780. doi: 10.1016/j.biopha.2023.114780. Epub 2023 Apr 25. Biomed Pharmacother. 2023. PMID: 37105075 Free article.
Despite this, little is known about the role of CCN6 in PDAC. The current study investigated the role of CCN6 in PDAC by generating CCN6-overexpressing PANC-1 cells (PANC-1-CCN6) by infecting lentivirus particles containing CCN6. ...Although the …
Despite this, little is known about the role of CCN6 in PDAC. The current study investigated the role of CCN6 in PDAC by gener …
CCN6 (WISP3): a new anti-cancer therapy?
Leask A. Leask A. J Cell Commun Signal. 2010 Dec;4(4):199-200. doi: 10.1007/s12079-010-0106-y. Epub 2010 Nov 9. J Cell Commun Signal. 2010. PMID: 21234127 Free PMC article.
A recent study from Huang and colleagues (Cancer Res. 70: 3340-50, 2010) suggests that CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon may result in the promotion of tumor survival. CCN6 may represent a novel therapeutic …
A recent study from Huang and colleagues (Cancer Res. 70: 3340-50, 2010) suggests that CCN6 (WISP3) is downregulated in aggres …
CCN6: a novel method of aTAKing cancer.
Leask A. Leask A. J Cell Commun Signal. 2013 Jun;7(2):161-2. doi: 10.1007/s12079-012-0189-8. Epub 2013 Jan 5. J Cell Commun Signal. 2013. PMID: 23292930 Free PMC article.
For example, CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon appears to result in the tumor survival by promoting Akt phosphorylation. In a recent report by Pal et al. (Cancer Res 72(18):4818-4828, 2012), CCN6 knockdown …
For example, CCN6 (WISP3) is downregulated in aggressive breast cancers, and this phenomenon appears to result in the tumor su …
78 results