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305 results

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Page 1
MiR-5195-3p functions as a tumor suppressor in prostate cancer via targeting CCNL1.
Zeng X, Hu Z, Shen Y, Wei X, Gan J, Liu Z. Zeng X, et al. Cell Mol Biol Lett. 2022 Mar 8;27(1):25. doi: 10.1186/s11658-022-00326-8. Cell Mol Biol Lett. 2022. PMID: 35260070 Free PMC article.
However, the clinical significance and biological function of miR-5195-3p in prostate cancer (PCa) have not been reported yet. METHODS: The expression levels of miR-5195-3p and Cyclin L1 (CCNL1) were determined using quantitative real-time PCR in clinical specimens …
However, the clinical significance and biological function of miR-5195-3p in prostate cancer (PCa) have not been reported yet. METHOD …
Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer.
Yang H, Liu B, Liu D, Yang Z, Zhang S, Xu P, Xing Y, Kutschick I, Pfeffer S, Britzen-Laurent N, Grützmann R, Pilarsky C. Yang H, et al. Cancers (Basel). 2022 Jun 27;14(13):3152. doi: 10.3390/cancers14133152. Cancers (Basel). 2022. PMID: 35804923 Free PMC article.
Pancreatic cancer is one of the most lethal cancers. Due to the difficulty of early diagnosis, most patients are diagnosed with metastasis or advanced-stage cancer, limiting the possibility of surgical treatment. ...We performed genome-wide CRISPR/Cas9 knocko …
Pancreatic cancer is one of the most lethal cancers. Due to the difficulty of early diagnosis, most patients are diagnosed wit …
A fine balance between CCNL1 and TIMP1 contributes to the development of breast cancer cells.
Peng L, Yanjiao M, Ai-guo W, Pengtao G, Jianhua L, Ju Y, Hongsheng O, Xichen Z. Peng L, et al. Biochem Biophys Res Commun. 2011 Jun 3;409(2):344-9. doi: 10.1016/j.bbrc.2011.05.021. Epub 2011 May 8. Biochem Biophys Res Commun. 2011. PMID: 21586274
Cyclin L1 (CCNL1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP1) are candidate genes involved in several types of cancer. However, the expression of CCNL1 and the relationship between CCNL1 and TIMP1 in breast cancer cells is unknown …
Cyclin L1 (CCNL1) and tissue inhibitor of matrix metalloproteinase-1 (TIMP1) are candidate genes involved in several types of canc …
Cyclin L1 participates in Adriamycin resistance and progression of osteosarcoma via PI3K/AKT-mTOR pathway.
Zhang Y, Zhang T, Chen L, Guo Z, Jiang X. Zhang Y, et al. Aging (Albany NY). 2024 Jun 26;16(14):11208-11223. doi: 10.18632/aging.205972. Epub 2024 Jun 26. Aging (Albany NY). 2024. PMID: 39024509 Free PMC article.
We found that CCNL1 expression levels were significantly associated with clinical prognosis of patients with OS and CCNL1 could promote OS proliferation and migration. In addition, we also revealed that cellular CCNL1 was significantly increased in ADM-resist …
We found that CCNL1 expression levels were significantly associated with clinical prognosis of patients with OS and CCNL1 coul …
MCM2 in human cancer: functions, mechanisms, and clinical significance.
Sun Y, Cheng Z, Liu S. Sun Y, et al. Mol Med. 2022 Oct 27;28(1):128. doi: 10.1186/s10020-022-00555-9. Mol Med. 2022. PMID: 36303105 Free PMC article. Review.
The overexpression of MCM2 was detected in multiple types of cancers, and the dysfunction of MCM2 was correlated with the progression and poor prognoses of malignant tumors. According to the altered expression of MCM2 and its correlation with clinicopathological features o …
The overexpression of MCM2 was detected in multiple types of cancers, and the dysfunction of MCM2 was correlated with the progression …
Identification of prevention marker associated with DNA replication in ovarian cancer: Expression of MCM2 protein and bioinformatics analysis.
Lv H, Du Y, Xin P, Zhong Y, Liu Z, Jing Y. Lv H, et al. Int J Biol Macromol. 2024 Nov;279(Pt 1):135079. doi: 10.1016/j.ijbiomac.2024.135079. Epub 2024 Aug 24. Int J Biol Macromol. 2024. PMID: 39187104
Ovarian cancer is one of the types of gynecological cancers that is considered to be particularly dangerous. ...Based on these findings, it seems that 10 genes have a role as hub genes in the prevention of ovarian cancer....
Ovarian cancer is one of the types of gynecological cancers that is considered to be particularly dangerous. ...Based on these …
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine.
Wen S, Wei Y, Zen C, Xiong W, Niu Y, Zhao Y. Wen S, et al. Mol Cancer. 2020 Dec 12;19(1):171. doi: 10.1186/s12943-020-01293-4. Mol Cancer. 2020. PMID: 33308223 Free PMC article.
High m6A level of NEAT1-1 was related to bone metastasis of prostate cancer and m6A level of NEAT1-1 was a powerful predictor of eventual death. Transcribed NEAT1-1 served as a bridge to facility the binding between CYCLINL1 and CDK19 and promoted the Pol II ser2 phosphory …
High m6A level of NEAT1-1 was related to bone metastasis of prostate cancer and m6A level of NEAT1-1 was a powerful predictor of even …
Pixantrone as a novel MCM2 inhibitor for ovarian cancer treatment.
Chen Q, Sun Y, Li H, Liu S, Zhang H, Cheng Z, Wang Y. Chen Q, et al. Eur J Pharmacol. 2024 Sep 15;979:176835. doi: 10.1016/j.ejphar.2024.176835. Epub 2024 Jul 19. Eur J Pharmacol. 2024. PMID: 39032764
Pixantrone significantly reduced the viability of ovarian cancer cells A2780 and SKOV3 in a dose- and time-dependent manner. In addition, pixantrone inhibited DNA replication, and induced cell cycle arrest and apoptosis in ovarian cancer cells via targeting MCM2. Kn …
Pixantrone significantly reduced the viability of ovarian cancer cells A2780 and SKOV3 in a dose- and time-dependent manner. In addit …
SCF(FBXW7) regulates G2-M progression through control of CCNL1 ubiquitination.
O'Brien S, Kelso S, Steinhart Z, Orlicky S, Mis M, Kim Y, Lin S, Sicheri F, Angers S. O'Brien S, et al. EMBO Rep. 2022 Dec 6;23(12):e55044. doi: 10.15252/embr.202255044. Epub 2022 Oct 24. EMBO Rep. 2022. PMID: 36278408 Free PMC article.
Here, using genome-wide CRISPR screens, we report a novel synthetic lethal genetic interaction between FBXW7 and CCNL1 and describe CCNL1 as a new substrate of the SCF-FBXW7 E3 ligase. Further analysis showed that the CCNL1-CDK11 complex is critical at the G2 …
Here, using genome-wide CRISPR screens, we report a novel synthetic lethal genetic interaction between FBXW7 and CCNL1 and describe …
Genomic instability in cancer.
Abbas T, Keaton MA, Dutta A. Abbas T, et al. Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a012914. doi: 10.1101/cshperspect.a012914. Cold Spring Harb Perspect Biol. 2013. PMID: 23335075 Free PMC article. Review.
305 results