Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 2
2001 2
2003 2
2004 2
2005 1
2006 1
2007 1
2008 2
2009 1
2011 1
2012 3
2013 5
2014 2
2015 4
2016 2
2017 4
2018 5
2019 5
2020 2
2021 4
2022 1
2023 3
2024 3
2025 3
2026 4

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

63 results

Results by year

Filters applied: . Clear all
Page 1
The Ccr4-Not Complex: Architecture and Structural Insights.
Collart MA, Panasenko OO. Collart MA, et al. Subcell Biochem. 2017;83:349-379. doi: 10.1007/978-3-319-46503-6_13. Subcell Biochem. 2017. PMID: 28271483 Review.
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . ...However the complex includes only o …
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic m …
The CCR4-NOT complex: a multifaceted sensor of molecular signals instructing eukaryotic mRNA translation and stability.
Caulier G, Siblini J, Sène L, Mauxion F, Séraphin B. Caulier G, et al. Nucleic Acids Res. 2025 Nov 26;53(22):gkaf1401. doi: 10.1093/nar/gkaf1401. Nucleic Acids Res. 2025. PMID: 41459743 Free PMC article. Review.
The CCR4-NOT complex is a multi-subunit assembly found in all eukaryotic cells. Yet, its composition varies across organisms, with a universally conserved core enriched by lineage-specific subunits. ...Over time, support for the originally proposed rol …
The CCR4-NOT complex is a multi-subunit assembly found in all eukaryotic cells. Yet, its composition varies across orga …
Ccr4-Not is at the core of the eukaryotic gene expression circuitry.
Villanyi Z, Collart MA. Villanyi Z, et al. Biochem Soc Trans. 2015 Dec;43(6):1253-8. doi: 10.1042/BST20150167. Biochem Soc Trans. 2015. PMID: 26614669 Review.
An integrated view of the findings about the Ccr4-Not complex suggests that it is involved in gene expression co-ordination. Since the discovery of the Not proteins in a selection for transcription regulators in yeast [Collart and Struhl (1994) Genes Dev. 8: …
An integrated view of the findings about the Ccr4-Not complex suggests that it is involved in gene expression co-ordina …
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF, Gingras AC. Youn JY, et al. Mol Cell. 2018 Feb 1;69(3):517-532.e11. doi: 10.1016/j.molcel.2017.12.020. Epub 2018 Jan 25. Mol Cell. 2018. PMID: 29395067 Free article.
Classical bait-prey analysis reveals connections of hundreds of proteins to distinct mRNA-associated processes or complexes, including the splicing and transcriptional elongation machineries (protein phosphatase 4) and the CCR4-NOT deadenylase complex …
Classical bait-prey analysis reveals connections of hundreds of proteins to distinct mRNA-associated processes or complexes, includin …
Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation.
Yin Z, Zhang Z, Lei Y, Klionsky DJ. Yin Z, et al. Autophagy. 2023 Feb;19(2):415-425. doi: 10.1080/15548627.2022.2036476. Epub 2022 Feb 15. Autophagy. 2023. PMID: 35167422 Free PMC article.
To maintain cellular homeostasis and prevent pathologies, the induction and amplitude of autophagy activity are finely controlled through regulation of ATG gene expression. Here we report that the Ccr4-Not complex in Saccharomyces cerevisiae has bidirectional …
To maintain cellular homeostasis and prevent pathologies, the induction and amplitude of autophagy activity are finely controlled through re …
Insights into the structure and architecture of the CCR4-NOT complex.
Xu K, Bai Y, Zhang A, Zhang Q, Bartlam MG. Xu K, et al. Front Genet. 2014 May 16;5:137. doi: 10.3389/fgene.2014.00137. eCollection 2014. Front Genet. 2014. PMID: 24904637 Free PMC article. Review.
The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription initiat …
The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolis …
Reconstitution of Human CCR4-NOT Complex from Purified Proteins and an Assay of Its Deadenylation Activity.
Levdansky Y, Valkov E. Levdansky Y, et al. Methods Mol Biol. 2024;2723:1-17. doi: 10.1007/978-1-0716-3481-3_1. Methods Mol Biol. 2024. PMID: 37824061
We describe protocols to produce and reconstitute an active human CCR4-NOT complex. Individual recombinant subunits are expressed in E. coli or baculovirus-infected insect cells, purified using column chromatography, and reconstituted into a stable complex …
We describe protocols to produce and reconstitute an active human CCR4-NOT complex. Individual recombinant subunits are …
The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity.
Chen H, Miller PW, Johnson DL, Laribee RN. Chen H, et al. PLoS Genet. 2020 Oct 16;16(10):e1009046. doi: 10.1371/journal.pgen.1009046. eCollection 2020 Oct. PLoS Genet. 2020. PMID: 33064727 Free PMC article.
The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. ...Although CWI signaling represses TORC1 signaling, we find that Ccr4-Not loss inhibits TORC1 independently of CWI a …
The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA t …
Ccr4-not ubiquitin ligase signaling regulates ribosomal protein homeostasis and inhibits 40S ribosomal autophagy.
Johnson DL, Kumar R, Kakhniashvili D, Pfeffer LM, Laribee RN. Johnson DL, et al. J Biol Chem. 2024 Aug;300(8):107582. doi: 10.1016/j.jbc.2024.107582. Epub 2024 Jul 16. J Biol Chem. 2024. PMID: 39025453 Free PMC article.
The Ccr4-Not complex contains the poorly understood Not4 ubiquitin ligase that functions in transcription, mRNA decay, translation, proteostasis, and endolysosomal nutrient signaling. ...Collectively, our data indicate that balanced Ccr4-Not ubi …
The Ccr4-Not complex contains the poorly understood Not4 ubiquitin ligase that functions in transcription, mRNA decay, …
Global control of gene expression in yeast by the Ccr4-Not complex.
Collart MA. Collart MA. Gene. 2003 Aug 14;313:1-16. doi: 10.1016/s0378-1119(03)00672-3. Gene. 2003. PMID: 12957374 Review.
The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. ...The evidence points to a role for the Ccr4-Not complex as a regulatory platform that senses nutrient levels and stress....
The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. ...The evidence po …
63 results