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1987 1
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1,367 results

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Page 1
DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs.
Guo H, Vuille JA, Wittner BS, Lachtara EM, Hou Y, Lin M, Zhao T, Raman AT, Russell HC, Reeves BA, Pleskow HM, Wu CL, Gnirke A, Meissner A, Efstathiou JA, Lee RJ, Toner M, Aryee MJ, Lawrence MS, Miyamoto DT, Maheswaran S, Haber DA. Guo H, et al. Cell. 2023 Jun 22;186(13):2765-2782.e28. doi: 10.1016/j.cell.2023.05.028. Epub 2023 Jun 15. Cell. 2023. PMID: 37327786 Free PMC article.
Cancer is characterized by hypomethylation-associated silencing of large chromatin domains, whose contribution to tumorigenesis is uncertain. ...
Cancer is characterized by hypomethylation-associated silencing of large chromatin domains, whose contribution to tumorigenesis is un
CD1a affects the recurrence and prognosis of ovarian cancer.
Zhu Q, Liu J, Xie Y, Wu C. Zhu Q, et al. J Obstet Gynaecol Res. 2025 Jan;51(1):e16120. doi: 10.1111/jog.16120. Epub 2024 Nov 7. J Obstet Gynaecol Res. 2025. PMID: 39511782
OBJECTIVE: Explored the correlation between CD1a expression in recurrence and prognosis of ovarian cancer (OV). METHODS: The CD1a expression profile in OV, recurrent OV, and normal tissues, as well as corresponding clinical data, were obtained from The Can
OBJECTIVE: Explored the correlation between CD1a expression in recurrence and prognosis of ovarian cancer (OV). METHODS: The …
Infiltration of CD1a-positive dendritic cells in advanced laryngeal cancer correlates with unfavorable outcomes post-laryngectomy.
Minesaki A, Kai K, Kuratomi Y, Aishima S. Minesaki A, et al. BMC Cancer. 2021 Aug 30;21(1):973. doi: 10.1186/s12885-021-08715-6. BMC Cancer. 2021. PMID: 34461859 Free PMC article.
Tumor-infiltrating CD1a(+) DCs have been reported to be associated with clinical outcomes in carcinomas of various organs, but the clinical impact of CD1a(+) DCs in laryngeal cancer remains to be unequivocally established. ...CONCLUSIONS: Our results demonstr …
Tumor-infiltrating CD1a(+) DCs have been reported to be associated with clinical outcomes in carcinomas of various organs, but the cl …
Analysis of CD1a-Positive Monocyte-Derived Cells in the Regional Lymph Nodes of Patients with Gallbladder Cancer.
Maeda S, Kai K, Kawasaki K, Tanaka T, Ide T, Noshiro H. Maeda S, et al. Int J Mol Sci. 2024 Nov 27;25(23):12763. doi: 10.3390/ijms252312763. Int J Mol Sci. 2024. PMID: 39684473 Free PMC article.
Dendritic cells (DCs) are known to be major antigen-presenting cells, and lymph nodes (LNs) play an important role in DC-mediated immune response. CD1a is known as a marker of monocyte-derived DCs. The present study focused on the infiltration of CD1a-positive DCs ( …
Dendritic cells (DCs) are known to be major antigen-presenting cells, and lymph nodes (LNs) play an important role in DC-mediated immune res …
CD1a Reactivity in Non-neoplastic Adenohypophysis.
Pisapia DJ, Rosenblum MK, Lavi E. Pisapia DJ, et al. Am J Surg Pathol. 2016 Jun;40(6):812-7. doi: 10.1097/PAS.0000000000000644. Am J Surg Pathol. 2016. PMID: 26999501 Free PMC article.
Here, we report that the MTB-1 monoclonal antibody against the CD1a antigen reacts to native adenohypophyseal epithelial cells. We show that immunohistochemistry for CD1a exhibits strong positivity in all autopsy and surgically resected non-neoplastic adenohy …
Here, we report that the MTB-1 monoclonal antibody against the CD1a antigen reacts to native adenohypophyseal epithelial cells …
Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System.
Yoo HJ, Kim NY, Kim JH. Yoo HJ, et al. Mol Cells. 2021 May 31;44(5):310-317. doi: 10.14348/molcells.2021.0059. Mol Cells. 2021. PMID: 33980746 Free PMC article. Review.
There are three modes by which the T-cell receptors of CD1a-restricted T cells interact with the CD1a:lipid complex: they bind to both the CD1a surface and the antigen or to only CD1a itself, which activates the T cell, or they are unable to bind becau …
There are three modes by which the T-cell receptors of CD1a-restricted T cells interact with the CD1a:lipid complex: they bind …
Efficient preclinical treatment of cortical T cell acute lymphoblastic leukemia with T lymphocytes secreting anti-CD1a T cell engagers.
Jiménez-Reinoso A, Tirado N, Martinez-Moreno A, Díaz VM, García-Peydró M, Hangiu O, Díez-Alonso L, Albitre Á, Penela P, Toribio ML, Menéndez P, Álvarez-Vallina L, Sánchez Martínez D. Jiménez-Reinoso A, et al. J Immunother Cancer. 2022 Dec;10(12):e005333. doi: 10.1136/jitc-2022-005333. J Immunother Cancer. 2022. PMID: 36564128 Free PMC article.
METHODS: We carried out a comprehensive study using robust in vitro and in vivo assays comparing the efficacy of engineered T cells either expressing a second-generation CD1a-CAR or secreting CD1a x CD3 T cell-engaging Antibodies (CD1a-STAb). RESULTS: We show …
METHODS: We carried out a comprehensive study using robust in vitro and in vivo assays comparing the efficacy of engineered T cells either e …
Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.
Jain N, Lamb AV, O'Brien S, Ravandi F, Konopleva M, Jabbour E, Zuo Z, Jorgensen J, Lin P, Pierce S, Thomas D, Rytting M, Borthakur G, Kadia T, Cortes J, Kantarjian HM, Khoury JD. Jain N, et al. Blood. 2016 Apr 14;127(15):1863-9. doi: 10.1182/blood-2015-08-661702. Epub 2016 Jan 8. Blood. 2016. PMID: 26747249 Free PMC article.
Patients with newly diagnosed T-ALL/LBL who received frontline chemotherapy between the years 2000 and 2014 at The University of Texas MD Anderson Cancer Center were identified and immunophenotypically categorized into early, thymic, and mature per the World Health Organiz …
Patients with newly diagnosed T-ALL/LBL who received frontline chemotherapy between the years 2000 and 2014 at The University of Texas MD An …
Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency.
Kobiela A, Hewelt-Belka W, Frąckowiak JE, Kordulewska N, Hovhannisyan L, Bogucka A, Etherington R, Piróg A, Dapic I, Gabrielsson S, Brown SJ, Ogg GS, Gutowska-Owsiak D. Kobiela A, et al. Front Immunol. 2024 Mar 22;15:1369238. doi: 10.3389/fimmu.2024.1369238. eCollection 2024. Front Immunol. 2024. PMID: 38585273 Free PMC article.
Lipidomic profiles of shFLGsEV showed a reduction in the long chain (LCFAs) and polyunsaturated fatty acids (PUFAs; permissive CD1a ligands) and increased content of the bulky headgroup sphingolipids (non-permissive ligands). ...DISCUSSION: We determined that sEVs constitu …
Lipidomic profiles of shFLGsEV showed a reduction in the long chain (LCFAs) and polyunsaturated fatty acids (PUFAs; permissive CD1a l …
CD1a positive putative tumour infiltrating dendritic cells in human breast cancer.
Coventry BJ. Coventry BJ. Anticancer Res. 1999 Jul-Aug;19(4B):3183-7. Anticancer Res. 1999. PMID: 10652609 Review.
CD1a molecules are expressed on dendritic cells (DC) during certain maturational phases coincident with the functions of antigen capture and processing. During these phases, CD1a is anchored to the cytoplasmic membrane through its cytoplasmic domain and the antigeni
CD1a molecules are expressed on dendritic cells (DC) during certain maturational phases coincident with the functions of antigen capt
1,367 results