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Did you mean CD38 and aging inflammation (101 results)?
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels.
Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. Chini CCS, et al. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199925 Free PMC article.
Decreased NAD(+) levels have been shown to contribute to metabolic dysfunction during aging. NAD(+) decline can be partially prevented by knockout of the enzyme CD38. However, it is not known how CD38 is regulated during aging, and how it …
Decreased NAD(+) levels have been shown to contribute to metabolic dysfunction during aging. NAD(+) decline can be part …
NADase CD38 is a key determinant of ovarian aging.
Yang Q, Chen W, Cong L, Wang M, Li H, Wang H, Luo X, Zhu J, Zeng X, Zhu Z, Xu Y, Lei M, Zhao Y, Wei C, Sun Y. Yang Q, et al. Nat Aging. 2024 Jan;4(1):110-128. doi: 10.1038/s43587-023-00532-9. Epub 2023 Dec 21. Nat Aging. 2024. PMID: 38129670 Free PMC article.
Here a comprehensive analysis of transcriptomic landscapes in different organs in young and middle-aged mice revealed that the ovaries showed earlier expression of age-associated genes, identifying increased NADase CD38 expression and decreased NAD(+) levels in the …
Here a comprehensive analysis of transcriptomic landscapes in different organs in young and middle-aged mice revealed that the ovaries showe …
Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2 macrophages, accumulate in metabolic tissues, including visceral white adipose tissue and liver, during ageing and acute responses to inflammation. These M1-like macrophages express high le …
Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2 macrophages, accumulate in metabolic tissues, including viscera …
Evolving concepts in NAD(+) metabolism.
Chini CCS, Zeidler JD, Kashyap S, Warner G, Chini EN. Chini CCS, et al. Cell Metab. 2021 Jun 1;33(6):1076-1087. doi: 10.1016/j.cmet.2021.04.003. Epub 2021 Apr 29. Cell Metab. 2021. PMID: 33930322 Free PMC article. Review.
Several evolving concepts on the metabolism, transport, and roles of these NAD pathway metabolites in disease states such as cancer, neurodegeneration, and aging have emerged in just the last few years. In this perspective, we discuss key recent discoveries and chan …
Several evolving concepts on the metabolism, transport, and roles of these NAD pathway metabolites in disease states such as cancer, …
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD(+) depletion.
Terao R, Lee TJ, Colasanti J, Pfeifer CW, Lin JB, Santeford A, Hase K, Yamaguchi S, Du D, Sohn BS, Sasaki Y, Yoshida M, Apte RS. Terao R, et al. Cell Rep. 2024 May 28;43(5):114102. doi: 10.1016/j.celrep.2024.114102. Epub 2024 Apr 17. Cell Rep. 2024. PMID: 38636518 Free PMC article.
Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic and genotoxic stresses, convergently acting through liver X nuc …
Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underly …
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD(+) …
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key p …
Inhibition of CD38 by 78c Enhanced NAD(+), Alleviated Inflammation, and Decreased Oxidative Stress in Old Murine Macrophages Induced by Oral Pathogens.
Cao K, Chowdhury N, Wellslager B, Hill WD, Yilmaz Ö, Yu H. Cao K, et al. Int J Mol Sci. 2025 Jun 26;26(13):6180. doi: 10.3390/ijms26136180. Int J Mol Sci. 2025. PMID: 40649955 Free PMC article.
CD38, a nicotinamide adenine dinucleotide (NAD(+)) glycohydrolase, increases in old murine macrophages after infection compared to young controls. ...These results suggest that the inhibition of CD38 by 78c is a promising therapeutic strategy to treat agin …
CD38, a nicotinamide adenine dinucleotide (NAD(+)) glycohydrolase, increases in old murine macrophages after infection compare …
[NAD(+) metabolism as a target for anti-aging].
Uchida H, Nakagawa T. Uchida H, et al. Nihon Yakurigaku Zasshi. 2025;160(4):268-273. doi: 10.1254/fpj.24072. Nihon Yakurigaku Zasshi. 2025. PMID: 40603033 Review. Japanese.
With age, DNA damage and chronic inflammation increase in organs, resulting in overconsumption of NAD(+) via PARP and CD38. The reduced NAD(+) levels decrease the activity of sirtuins and PARPs and impair energy metabolism, ultimately leading to agi …
With age, DNA damage and chronic inflammation increase in organs, resulting in overconsumption of NAD(+) via PARP and CD38 …
The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research.
Kitada M, Araki SI, Koya D. Kitada M, et al. Cells. 2023 Feb 12;12(4):595. doi: 10.3390/cells12040595. Cells. 2023. PMID: 36831262 Free PMC article. Review.
It is also involved in the regulation of many cellular functions including inflammation, oxidative stress and differentiation. NAD(+) declines with aging in various organs, and the reduction in NAD(+) is possibly involved in the development of age-rela …
It is also involved in the regulation of many cellular functions including inflammation, oxidative stress and differentiation. NAD …
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.
Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W. Chini EN, et al. Trends Pharmacol Sci. 2018 Apr;39(4):424-436. doi: 10.1016/j.tips.2018.02.001. Epub 2018 Feb 23. Trends Pharmacol Sci. 2018. PMID: 29482842 Free PMC article. Review.
The protein CD38 (cluster of differentiation 38) is a multifunctional enzyme that degrades NAD and modulates cellular NAD homeostasis. At the physiological level, CD38 has been implicated in the regulation of metabolism and in the pathogenesis of multi …
The protein CD38 (cluster of differentiation 38) is a multifunctional enzyme that degrades NAD and modulates cellular NAD …
32 results