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CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N, Bishop K, van der Stok M, Nair K, Khan N, Crawford H, Payne R, Leslie A, Prado J, Prendergast A, Frater J, McCarthy N, Brander C, Learn GH, Nickle D, Rousseau C, Coovadia H, Mullins JI, Heckerman D, Walker BD, Goulder P. Kiepiela P, et al. Nat Med. 2007 Jan;13(1):46-53. doi: 10.1038/nm1520. Epub 2006 Dec 17. Nat Med. 2007. PMID: 17173051
Of the HIV proteins targeted, only Gag-specific responses were associated with lowering viremia. ...Association of the specific CD8(+) T-cell response with low viremia was independent of HLA type and unrelated to epit …
Of the HIV proteins targeted, only Gag-specific responses were associated with lowering viremia. ...Associati …
Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity.
Price DA, Scullard G, Oxenius A, Braganza R, Beddows SA, Kazmi S, Clarke JR, Johnson GE, Weber JN, Phillips RE. Price DA, et al. J Virol. 2003 May;77(10):6041-9. doi: 10.1128/jvi.77.10.6041-6049.2003. J Virol. 2003. PMID: 12719595 Free PMC article. Clinical Trial.
Many individuals chronically infected with human immunodeficiency virus type 1 (HIV-1) experience a recrudescence of plasma virus during continuous combination antiretroviral therapy (ART) due either to the emergence of drug-resistant viruses or …
Many individuals chronically infected with human immunodeficiency virus type 1 (HIV-1) experience a recrudescenc …
A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection.
Imami N, Pires A, Hardy G, Wilson J, Gazzard B, Gotch F. Imami N, et al. J Virol. 2002 Sep;76(18):9011-23. doi: 10.1128/jvi.76.18.9011-9023.2002. J Virol. 2002. PMID: 12186885 Free PMC article.
Previous reports have emphasized the requirements for strong type 1 cell-mediated responses in the control of human immunodeficiency virus type 1 (HIV-1). HIV-1 Gag p24-specific CD4 helper T-lymphocyte (HTL) responses have been sho …
Previous reports have emphasized the requirements for strong type 1 cell-mediated responses in the control of human immunod …