CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.
Immunity. 2010.
PMID: 20153221
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CD95-Ligand not peripheral myeloid cells activates fyn kinase to t igger their recruitment of the inflammatory site
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CD95-Ligand on Peripheral Myeloid Cells Activates Syk Kinase to Trigger Their Recruitment to the Inflammatory Site
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Non-apoptotic Fas signaling.
Cytokine Growth Factor Rev. 2003 Feb;14(1):53-66. doi: 10.1016/s1359-6101(02)00072-2.
Cytokine Growth Factor Rev. 2003.
PMID: 12485619
Review.
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-indu …
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand fam …
Biology of FasL.
Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):325-35. doi: 10.1016/s1359-6101(03)00028-5.
Cytokine Growth Factor Rev. 2003.
PMID: 12787569
Review.
FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. ...
FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor …
Metalloprotease-mediated cleavage of CD95 ligand.
FEBS J. 2023 Jun;290(12):3145-3164. doi: 10.1111/febs.16737. Epub 2023 Feb 8.
FEBS J. 2023.
PMID: 36694998
Free article.
CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or n …
CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. Stimulation of …
The CD95(APO-1/Fas)/CD95L system.
Toxicol Lett. 1998 Dec 28;102-103:131-7. doi: 10.1016/s0378-4274(98)00297-5.
Toxicol Lett. 1998.
PMID: 10022244
Review.
The CD95 system is one of the best studied death systems and plays an essential role in the immune system, particularly in deletion of peripheral T-cells and in homeostasis of the liver. Here genetic defects in the CD95 system are discussed as well as …
The CD95 system is one of the best studied death systems and plays an essential role in the immune system, particularly in deletion o …
The role of CD95 and CD95 ligand in cancer.
Cell Death Differ. 2015 Apr;22(4):549-59. doi: 10.1038/cdd.2015.3. Epub 2015 Feb 6.
Cell Death Differ. 2015.
PMID: 25656654
Free PMC article.
Review.
CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. ...CD95 and CD95L were discovered to be critical survival factors for cancer …
CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death receptor/death ligand system that media …
CD95/Fas and metastatic disease: What does not kill you makes you stronger.
Semin Cancer Biol. 2020 Feb;60:121-131. doi: 10.1016/j.semcancer.2019.06.004. Epub 2019 Jun 6.
Semin Cancer Biol. 2020.
PMID: 31176682
Free article.
Review.
At least two different forms of CD95 L exist. The multi-aggregated transmembrane ligand (m-CD95 L) is cleaved by metalloproteases to release a homotrimeric soluble ligand (s-CD95 L). ...Novel inhibitors targeting the pro-inflammatory role …
At least two different forms of CD95 L exist. The multi-aggregated transmembrane ligand (m-CD95 L) is cleaved by metall …
CD95 signaling in cancer treatment.
Curr Pharm Des. 2014;20(17):2809-18. doi: 10.2174/13816128113199990589.
Curr Pharm Des. 2014.
PMID: 23944368
Review.
The CD95/CD95 ligand (CD95L) system regulates cell death, which plays a relevant role in cancer. ...However, a complete loss of CD95 is rarely seen in human cancers, and many cancer cells express large quantities of CD95. ...
The CD95/CD95 ligand (CD95L) system regulates cell death, which plays a relevant role in cancer. ...However, a complete …
Fas-induced apoptosis in B cells.
Apoptosis. 2003 Oct;8(5):451-60. doi: 10.1023/a:1025534223168.
Apoptosis. 2003.
PMID: 12975576
Review.
Engagement of the cell surface receptor Fas/APO-1 (CD95) initiates a sequence of intracellular events that leads to apoptotic cell death, and this outcome occurs in B cells as it does in other cell types. Fas signaling for B cell death is of particular …
Engagement of the cell surface receptor Fas/APO-1 (CD95) initiates a sequence of intracellular events that leads to apoptotic …
CD95-ligand contributes to abdominal aortic aneurysm progression by modulating inflammation.
Cardiovasc Res. 2019 Mar 15;115(4):807-818. doi: 10.1093/cvr/cvy264.
Cardiovasc Res. 2019.
PMID: 30428004
Free PMC article.
CD95 is an inflammatory mediator and an apoptosis inducer. Previous studies have shown elevated expression of CD95 or CD95L in the aortic tissue of AAA patients. ...WT/CD95L-/-BM mice were resistant to aneurysm formation compared to their controls. Inflamm …
CD95 is an inflammatory mediator and an apoptosis inducer. Previous studies have shown elevated expression of CD95 or C …
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.
Immunity. 2010 Feb 26;32(2):240-52. doi: 10.1016/j.immuni.2010.01.011. Epub 2010 Feb 11.
Immunity. 2010.
PMID: 20153221
Free article.
Injury to the central nervous system initiates an uncontrolled inflammatory response that results in both tissue repair and destruction. Here, we showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, …
Injury to the central nervous system initiates an uncontrolled inflammatory response that results in both tissue repair and destructi …
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