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Year Number of Results
2013 1
2014 2
2015 3
2016 2
2017 3
2018 3
2019 3
2020 1
2021 3
2022 1
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CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading.
Huang X, Liang X, Zhou Y, Li H, Du H, Suo Y, Liu W, Jin R, Chai B, Duan R, Li H, Li Q. Huang X, et al. Int J Biol Sci. 2021 Jan 1;17(1):353-367. doi: 10.7150/ijbs.51309. eCollection 2021. Int J Biol Sci. 2021. PMID: 33390855 Free PMC article.
Furthermore, the forkhead box O1/Kruppel-like factor 4 (FOXO1/KLF4) pathway was activated and contributed to the keratinocyte dedifferentiation. In vivo studies showed that mechanical loading and Cdh1 interference facilitated epidermal dedifferentiation and p …
Furthermore, the forkhead box O1/Kruppel-like factor 4 (FOXO1/KLF4) pathway was activated and contributed to the keratinocyte dediffe …
Identification of a new regulation pathway of EGFR and E-cadherin dynamics.
Proux-Gillardeaux V, Advedissian T, Perin C, Gelly JC, Viguier M, Deshayes F. Proux-Gillardeaux V, et al. Sci Rep. 2021 Nov 22;11(1):22705. doi: 10.1038/s41598-021-02042-3. Sci Rep. 2021. PMID: 34811416 Free PMC article.
In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study therefore reveals that galectin-7 controls epidermal homeostasis through the regulation of E-cadherin/EGFR balance....
In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study …
ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.
Smirnov A, Lena AM, Cappello A, Panatta E, Anemona L, Bischetti S, Annicchiarico-Petruzzelli M, Mauriello A, Melino G, Candi E. Smirnov A, et al. Oncogene. 2019 Mar;38(10):1625-1638. doi: 10.1038/s41388-018-0509-4. Epub 2018 Oct 18. Oncogene. 2019. PMID: 30337687 Free PMC article.
Similarly, limited data are available to understand if deregulation of the cell-cell adhesion programme is important in tumour formation. Here, using the epidermis as an experimental model with the RNA sequencing approach, we identify a novel p63-regulated gene induced dur …
Similarly, limited data are available to understand if deregulation of the cell-cell adhesion programme is important in tumour formation. He …
p120-catenin down-regulation and epidermal growth factor receptor overexpression results in a transformed epithelium that mimics esophageal squamous cell carcinoma.
Lehman HL, Yang X, Welsh PA, Stairs DB. Lehman HL, et al. Am J Pathol. 2015 Jan;185(1):240-51. doi: 10.1016/j.ajpath.2014.09.008. Am J Pathol. 2015. PMID: 25529795 Free PMC article.
The molecular pathogenesis underlying the invasive mechanism of ESCC is not well known because of the lack of existing models to study this disease. p120-Catenin (p120ctn) and the epidermal growth factor receptor (EGFR) have each been implicated in several cancers, includi …
The molecular pathogenesis underlying the invasive mechanism of ESCC is not well known because of the lack of existing models to study this …
TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition.
Sharma S, Goswami R, Zhang DX, Rahaman SO. Sharma S, et al. J Cell Mol Med. 2019 Feb;23(2):761-774. doi: 10.1111/jcmm.13972. Epub 2018 Nov 18. J Cell Mol Med. 2019. PMID: 30450767 Free PMC article.
Specifically, we found that: (a) genetic ablation or pharmacological inhibition of TRPV4 blocked matrix stiffness and TGFbeta1-induced EMT in normal mouse primary epidermal keratinocytes (NMEKs) as determined by changes in morphology, adhesion, migration and alterat …
Specifically, we found that: (a) genetic ablation or pharmacological inhibition of TRPV4 blocked matrix stiffness and TGFbeta1-induced EMT i …
[Expression of β-catenin in Skin Lesions of Patients with Scleroderma and Its Effect on Epithelial-Mesenchymal Transition of Human Epidermal Keratinocytes].
Liu JJ, Yang HF, Li YJ, Chen YM. Liu JJ, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019 Sep;50(5):654-659. Sichuan Da Xue Xue Bao Yi Xue Ban. 2019. PMID: 31762233 Chinese.
OBJECTIVE: To investigate the expression of beta-catenin in the skin lesions of patients with systemic scleroderma (SSc) and its effect on epithelial-mesenchymal transition (EMT) of human epidermal keratinocytes. METHODS: The expression of beta-catenin, Snail1 and E …
OBJECTIVE: To investigate the expression of beta-catenin in the skin lesions of patients with systemic scleroderma (SSc) and its effect on e …
IRF6 Regulates the Delivery of E-Cadherin to the Plasma Membrane.
Antiguas A, DeMali KA, Dunnwald M. Antiguas A, et al. J Invest Dermatol. 2022 Feb;142(2):314-322. doi: 10.1016/j.jid.2021.06.031. Epub 2021 Jul 24. J Invest Dermatol. 2022. PMID: 34310950
IRF6 is a transcription factor that is required for craniofacial development and epidermal morphogenesis. Specifically, Irf6-deficient mice lack the terminally differentiated epidermal layers, leading to an absence of barrier function. ...However, the mechanisms by …
IRF6 is a transcription factor that is required for craniofacial development and epidermal morphogenesis. Specifically, Irf6-deficien …
Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes.
Ho E, Ivanova IA, Dagnino L. Ho E, et al. Biochim Biophys Acta. 2016 Dec;1863(12):2892-2904. doi: 10.1016/j.bbamcr.2016.09.007. Epub 2016 Sep 11. Biochim Biophys Acta. 2016. PMID: 27627840 Free article.
The formation of tight cell-cell junctions is essential in the epidermis for its barrier properties. In this tissue, keratinocytes follow a differentiation program tightly associated with their movement from the innermost basal to the outer suprabasal layers, and wi …
The formation of tight cell-cell junctions is essential in the epidermis for its barrier properties. In this tissue, keratinocytes
CDH1 regulates E2F1 degradation in response to differentiation signals in keratinocytes.
Singh RK, Dagnino L. Singh RK, et al. Oncotarget. 2017 Jan 17;8(3):4977-4993. doi: 10.18632/oncotarget.13636. Oncotarget. 2017. PMID: 27903963 Free PMC article.
We found that Cdh1 associates with E2F1 in keratinocytes. Inhibition or RNAi-mediated silencing of Cdh1 prevents E2F1 degradation in response to differentiation signals. Our results reveal novel regulatory mechanisms that jointly modulate post-translational m …
We found that Cdh1 associates with E2F1 in keratinocytes. Inhibition or RNAi-mediated silencing of Cdh1 prevents E2F1 d …
Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes.
Tu CL, You M. Tu CL, et al. J Dermatol Sci. 2014 Feb;73(2):142-51. doi: 10.1016/j.jdermsci.2013.09.007. Epub 2013 Sep 26. J Dermatol Sci. 2014. PMID: 24120284 Free PMC article.
BACKGROUND: Extracellular Ca(2+) (Cao(2+))-induced E-cadherin-mediated cell-cell adhesion plays a critical role in promoting differentiation in epidermal keratinocytes. Our previous studies show that the calcium-sensing receptor (CaR) regulates keratinocyte c …
BACKGROUND: Extracellular Ca(2+) (Cao(2+))-induced E-cadherin-mediated cell-cell adhesion plays a critical role in promoting differentiation …
17 results