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NR4A3 inhibits the tumor progression of hepatocellular carcinoma by inducing cell cycle G0/G1 phase arrest and upregulation of CDKN2AIP expression.
Zhao X, Min X, Wang Z, Chen X, Ge C, Zhao F, Tian H, Chen T, Li J. Zhao X, et al. Int J Biol Sci. 2024 Oct 28;20(15):5850-5867. doi: 10.7150/ijbs.95174. eCollection 2024. Int J Biol Sci. 2024. PMID: 39664575 Free PMC article.
Considering that the specific mechanism by which NR4A3 regulates gene transcription in HCC (hepatocellular carcinoma) has not yet been elucidated, our study aimed to explore the transcriptional role of NR4A3 in regulating the target gene CDKN2AIP (CDKN2A interacting protei …
Considering that the specific mechanism by which NR4A3 regulates gene transcription in HCC (hepatocellular carcinoma) has not yet been eluci …
CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4beta.
Cao Y, Chen Z, Qin Z, Qian K, Liu T, Zhang Y. Cao Y, et al. Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(5):604-614. doi: 10.3724/abbs.2022040. Acta Biochim Biophys Sin (Shanghai). 2022. PMID: 35593475 Free PMC article.
CDKN2AIP exhibits anti-tumor activity by interacting with CARM1 and eIF4beta. CDKN2AIP induces testicular seminoma cell senescence by suppressing CARM1 expression and eIF4beta phosphorylation. The CDKN2AIP-CARM1 and CDKN2AIP-eIF4beta interactions, whic …
CDKN2AIP exhibits anti-tumor activity by interacting with CARM1 and eIF4beta. CDKN2AIP induces testicular seminoma cell senesc …
Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma.
Zhang H, Yu Z, Wu B, Sun F. Zhang H, et al. Bioengineered. 2021 Dec;12(2):9991-9999. doi: 10.1080/21655979.2021.1989258. Bioengineered. 2021. PMID: 34637672 Free PMC article.
We found that circFOXP1 expression was increased in osteosarcoma, and could promote angiogenesis in osteosarcoma through upregulating CDKN2AIP expression. Moreover, circFOXP1 could directly bind to miR-127-5p, which further targets CDKN2AIP directly. In conclusion, …
We found that circFOXP1 expression was increased in osteosarcoma, and could promote angiogenesis in osteosarcoma through upregulating CDK …
Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients.
Wong S, Ehrhart EJ, Stewart S, Zismann V, Cawley J, Halperin R, Briones N, Richter K, Sivaprakasam K, Perdigones N, Contente-Cuomo T, Facista S, Trent JM, Murtaza M, Khanna C, Hendricks WPD. Wong S, et al. PLoS One. 2022 Jul 22;17(7):e0264986. doi: 10.1371/journal.pone.0264986. eCollection 2022. PLoS One. 2022. PMID: 35867969 Free PMC article.
Cancer genomic heterogeneity presents significant challenges for understanding oncogenic processes and for cancer's clinical management. ...Multi-platform genomic analysis included matched tumor/normal targeted sequencing panel and exome sequencing. We found …
Cancer genomic heterogeneity presents significant challenges for understanding oncogenic processes and for cancer's cli …
Discovery of prognostic biomarkers for predicting lung cancer metastasis using microarray and survival data.
Huang HL, Wu YC, Su LJ, Huang YJ, Charoenkwan P, Chen WL, Lee HC, Chu WC, Ho SY. Huang HL, et al. BMC Bioinformatics. 2015 Feb 21;16:54. doi: 10.1186/s12859-015-0463-x. BMC Bioinformatics. 2015. PMID: 25881029 Free PMC article.
BACKGROUND: Few studies have investigated prognostic biomarkers of distant metastases of lung cancer. One of the central difficulties in identifying biomarkers from microarray data is the availability of only a small number of samples, which results overtraining. ...Sevent …
BACKGROUND: Few studies have investigated prognostic biomarkers of distant metastases of lung cancer. One of the central difficulties …
Genome Wide Differential Expression Profiles in Nevus Sebaceous Uncovered Low Expression of CDKN2AIP and Construction of a ceRNA Network.
Yang X, Qiao R, Ni N, Zhang Q, Zhang K, Shao X, Cheng W, Sun J, Jiang Y. Yang X, et al. Clin Cosmet Investig Dermatol. 2022 Mar 25;15:519-533. doi: 10.2147/CCID.S357755. eCollection 2022. Clin Cosmet Investig Dermatol. 2022. PMID: 35368624 Free PMC article.
Verification by real-time PCR and Western blot indicated that CDKN2AIP gene was downregulated consistently in NS tissue compared to normal scalp skin. ...We identified a downregulated gene, CDKN2AIP, as a target of differentially expressed mRNA and predicted a ceRNA …
Verification by real-time PCR and Western blot indicated that CDKN2AIP gene was downregulated consistently in NS tissue compared to n …
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.
Saul N, Dhondt I, Kuokkanen M, Perola M, Verschuuren C, Wouters B, von Chrzanowski H, De Vos WH, Temmerman L, Luyten W, Zečić A, Loier T, Schmitz-Linneweber C, Braeckman BP. Saul N, et al. Biogerontology. 2022 Aug;23(4):431-452. doi: 10.1007/s10522-022-09969-8. Epub 2022 Jun 24. Biogerontology. 2022. PMID: 35748965 Free PMC article.
Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, dementia, cancer, chronic obstructive pulmonary disease (COPD), asthma, rheumatism, Crohn's disease, malabsorption or kidney disease. …
Healthy individuals were defined as free from cardiovascular disease, stroke, heart failure, major adverse cardiovascular event, diabetes, d …
Proteomic approach to discover human cancer viruses from formalin-fixed tissues.
Toptan T, Cantrell PS, Zeng X, Liu Y, Sun M, Yates NA, Chang Y, Moore PS. Toptan T, et al. JCI Insight. 2020 Nov 19;5(22):e143003. doi: 10.1172/jci.insight.143003. JCI Insight. 2020. PMID: 33055416 Free PMC article.
Using 23 (12 MCV+, 11 MCV-) formalin-fixed MCC, DPS identified both viral and human biomarkers (MCV large T antigen, CDKN2AIP, SERPINB5, and TRIM29) that discriminate MCV+ and MCV- MCC. Statistical analysis of 498,131 dMS features not matching the human proteome by DPS rev …
Using 23 (12 MCV+, 11 MCV-) formalin-fixed MCC, DPS identified both viral and human biomarkers (MCV large T antigen, CDKN2AIP, SERPIN …
Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.
Yi CH, Zheng T, Leaderer D, Hoffman A, Zhu Y. Yi CH, et al. Cancer Lett. 2009 Nov 1;284(2):149-56. doi: 10.1016/j.canlet.2009.04.017. Epub 2009 May 19. Cancer Lett. 2009. PMID: 19457610 Free PMC article.
Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, and relevant biological pathways. ...Subsequent real-time PCR assays confirmed 16 of these targets, and 9 of th …
Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer …
Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis.
Solís-Fernández G, Montero-Calle A, Martínez-Useros J, López-Janeiro Á, de Los Ríos V, Sanz R, Dziakova J, Milagrosa E, Fernández-Aceñero MJ, Peláez-García A, Casal JI, Hofkens J, Rocha S, Barderas R. Solís-Fernández G, et al. Cells. 2022 Jan 27;11(3):447. doi: 10.3390/cells11030447. Cells. 2022. PMID: 35159257 Free PMC article.
Metastasis is the primary cause of colorectal cancer (CRC) death. The liver and lung, besides adjacent lymph nodes, are the most common sites of metastasis. ...Our results demonstrate that the analysis of cell extracts dilutes protein alterations in abundance in specific l …
Metastasis is the primary cause of colorectal cancer (CRC) death. The liver and lung, besides adjacent lymph nodes, are the most comm …
26 results