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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2004 1
2005 1
2006 1
2007 1
2008 3
2009 6
2010 2
2011 8
2012 7
2013 8
2014 6
2015 9
2016 11
2017 6
2018 12
2019 9
2020 7
2021 14
2022 10
2023 8
2024 6

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120 results

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Page 1
CEBPA phase separation links transcriptional activity and 3D chromatin hubs.
Christou-Kent M, Cuartero S, Garcia-Cabau C, Ruehle J, Naderi J, Erber J, Neguembor MV, Plana-Carmona M, Alcoverro-Bertran M, De Andres-Aguayo L, Klonizakis A, Julià-Vilella E, Lynch C, Serrano M, Hnisz D, Salvatella X, Graf T, Stik G. Christou-Kent M, et al. Cell Rep. 2023 Aug 29;42(8):112897. doi: 10.1016/j.celrep.2023.112897. Epub 2023 Jul 29. Cell Rep. 2023. PMID: 37516962 Free article.
Both overexpressing B cells and native CEBPA-expressing cell types such as primary granulocyte-macrophage progenitors, liver cells, and trophectoderm cells reveal nuclear CEBPA foci and long-range 3D chromatin hubs at CEBPA-bound regions. In short, we …
Both overexpressing B cells and native CEBPA-expressing cell types such as primary granulocyte-macrophage progenitors, liver c …
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK. Hilgendorf KI, et al. Cell. 2019 Nov 27;179(6):1289-1305.e21. doi: 10.1016/j.cell.2019.11.005. Epub 2019 Nov 21. Cell. 2019. PMID: 31761534 Free PMC article.
Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer.
Hashimoto A, Sarker D, Reebye V, Jarvis S, Sodergren MH, Kossenkov A, Sanseviero E, Raulf N, Vasara J, Andrikakou P, Meyer T, Huang KW, Plummer R, Chee CE, Spalding D, Pai M, Khan S, Pinato DJ, Sharma R, Basu B, Palmer D, Ma YT, Evans J, Habib R, Martirosyan A, Elasri N, Reynaud A, Rossi JJ, Cobbold M, Habib NA, Gabrilovich DI. Hashimoto A, et al. Clin Cancer Res. 2021 Nov 1;27(21):5961-5978. doi: 10.1158/1078-0432.CCR-21-0986. Epub 2021 Aug 18. Clin Cancer Res. 2021. PMID: 34407972 Free PMC article. Clinical Trial.
MTL-CEBPA treatment in those patients caused a marked decrease in peripheral blood monocytic myeloid-derived suppressor cell (M-MDSC) numbers and an overall reduction in the numbers of protumoral M2 tumor-associated macrophages (TAM). ...The antitumor effects of MTL …
MTL-CEBPA treatment in those patients caused a marked decrease in peripheral blood monocytic myeloid-derived suppressor cell (M-MDSC) …
Age-related liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit.
Duan JL, Liu JJ, Ruan B, Ding J, Fang ZQ, Xu H, Song P, Xu C, Li ZW, Du W, Xu M, Ling YW, He F, Wang L. Duan JL, et al. Nat Aging. 2023 Mar;3(3):258-274. doi: 10.1038/s43587-022-00348-z. Epub 2022 Dec 30. Nat Aging. 2023. PMID: 37118422
Mechanistically, C-kit transcriptionally inhibits chemokine (C-X-C motif) receptor (CXCR)4 via CCAAT enhancer-binding protein alpha (CEBPA). Blocking CXCR4 signaling abolishes LSEC-macrophage-neutrophil cross-talk and leads to the recovery of C-kit-deficient mice wi …
Mechanistically, C-kit transcriptionally inhibits chemokine (C-X-C motif) receptor (CXCR)4 via CCAAT enhancer-binding protein alpha (CEBP
Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.
Ko MS, Yun JY, Baek IJ, Jang JE, Hwang JJ, Lee SE, Heo SH, Bader DA, Lee CH, Han J, Moon JS, Lee JM, Hong EG, Lee IK, Kim SW, Park JY, Hartig SM, Kang UJ, Moore DD, Koh EH, Lee KU. Ko MS, et al. Autophagy. 2021 May;17(5):1205-1221. doi: 10.1080/15548627.2020.1753002. Epub 2020 May 13. Autophagy. 2021. PMID: 32400277 Free PMC article.
The ability of the nlrp3 knockouts to rescue BAT dysfunction suggests the transcriptional function of NLRP3 as an unexpected, but a quite specific therapeutic target for obesity-related metabolic diseases.Abbreviations: ACTB: actin, beta; BAPs: brown adipocyte precursors; BAT: br …
The ability of the nlrp3 knockouts to rescue BAT dysfunction suggests the transcriptional function of NLRP3 as an unexpected, but a quite sp …
The regulatory control of Cebpa enhancers and silencers in the myeloid and red-blood cell lineages.
Repele A, Krueger S, Bhattacharyya T, Tuineau MY, Manu. Repele A, et al. PLoS One. 2019 Jun 10;14(6):e0217580. doi: 10.1371/journal.pone.0217580. eCollection 2019. PLoS One. 2019. PMID: 31181110 Free PMC article.
The expression of Cebpa itself is finely modulated, as Cebpa is expressed at high and intermediate levels in neutrophils and macrophages respectively and downregulated in non-myeloid lineages. The cis-regulatory logic underlying the lineage-specific modulatio …
The expression of Cebpa itself is finely modulated, as Cebpa is expressed at high and intermediate levels in neutrophils and …
C/EBPalpha regulates macrophage activation and systemic metabolism.
Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. Lee B, et al. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1144-54. doi: 10.1152/ajpendo.00002.2014. Epub 2014 Apr 1. Am J Physiol Endocrinol Metab. 2014. PMID: 24691027 Free PMC article.
Macrophage infiltration plays an important role in obesity-induced insulin resistance. CCAAT enhancer-binding protein-alpha (C/EBPalpha) is a transcription factor that is highly expressed in macrophages. To examine the roles of C/EBPalpha in regulating macrophage
Macrophage infiltration plays an important role in obesity-induced insulin resistance. CCAAT enhancer-binding protein-alpha (C/EBPalp
Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression.
Yan T, Yan N, Xia Y, Sawaswong V, Zhu X, Dias HB, Aibara D, Takahashi S, Hamada K, Saito Y, Li G, Liu H, Yan H, Velenosi TJ, Krausz KW, Huang J, Kimura S, Rotman Y, Qu A, Hao H, Gonzalez FJ. Yan T, et al. J Clin Invest. 2024 Apr 1;134(7):e166731. doi: 10.1172/JCI166731. J Clin Invest. 2024. PMID: 38557493 Free PMC article.
CEBPA is also expressed in hepatocytes and regulates glucolipid homeostasis; however, the role of hepatocyte-specific CEBPA in modulating liver fibrosis progression is largely unknown. Here, hepatic CEBPA expression was found to be decreased during MASH progr
CEBPA is also expressed in hepatocytes and regulates glucolipid homeostasis; however, the role of hepatocyte-specific CEBPA in
Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity.
Torcal Garcia G, Kowenz-Leutz E, Tian TV, Klonizakis A, Lerner J, De Andres-Aguayo L, Sapozhnikova V, Berenguer C, Carmona MP, Casadesus MV, Bulteau R, Francesconi M, Peiro S, Mertins P, Zaret K, Leutz A, Graf T. Torcal Garcia G, et al. Elife. 2023 Jun 27;12:e83951. doi: 10.7554/eLife.83951. Elife. 2023. PMID: 37365888 Free PMC article.
Here, we describe how the speed of C/EBPalpha-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. ...Increasing the proportion of unmethylated C/EBPalpha in granulocyte/macrophage progenitors by inhibiting Car …
Here, we describe how the speed of C/EBPalpha-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mo …
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.
Avellino R, Havermans M, Erpelinck C, Sanders MA, Hoogenboezem R, van de Werken HJ, Rombouts E, van Lom K, van Strien PM, Gebhard C, Rehli M, Pimanda J, Beck D, Erkeland S, Kuiken T, de Looper H, Gröschel S, Touw I, Bindels E, Delwel R. Avellino R, et al. Blood. 2016 Jun 16;127(24):2991-3003. doi: 10.1182/blood-2016-01-695759. Epub 2016 Mar 10. Blood. 2016. PMID: 26966090 Free PMC article.
Of these, 1 enhancer located +42 kb from CEBPA is active and engages with the CEBPA promoter in myeloid cells only. Germ line deletion of the homologous enhancer in mice in vivo reduces Cebpa levels exclusively in hematopoietic stem cells (HSCs) and myeloid-p …
Of these, 1 enhancer located +42 kb from CEBPA is active and engages with the CEBPA promoter in myeloid cells only. Germ line …
120 results