Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2004 1
2005 1
2006 1
2007 1
2008 3
2009 6
2010 2
2011 8
2012 7
2013 8
2014 6
2015 9
2016 11
2017 6
2018 12
2019 9
2020 7
2021 14
2022 10
2023 8
2024 12
2025 9
2026 4

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

136 results

Results by year

Filters applied: . Clear all
Page 1
CEBPA phase separation links transcriptional activity and 3D chromatin hubs.
Christou-Kent M, Cuartero S, Garcia-Cabau C, Ruehle J, Naderi J, Erber J, Neguembor MV, Plana-Carmona M, Alcoverro-Bertran M, De Andres-Aguayo L, Klonizakis A, Julià-Vilella E, Lynch C, Serrano M, Hnisz D, Salvatella X, Graf T, Stik G. Christou-Kent M, et al. Cell Rep. 2023 Aug 29;42(8):112897. doi: 10.1016/j.celrep.2023.112897. Epub 2023 Jul 29. Cell Rep. 2023. PMID: 37516962 Free article.
Here we present evidence that the lineage-instructive TF CEBPA drives extensive chromatin compartment switching and promotes the formation of long-range chromatin hubs during induced B cell-to-macrophage transdifferentiation. Mechanistically, we find that the intrin …
Here we present evidence that the lineage-instructive TF CEBPA drives extensive chromatin compartment switching and promotes the form …
Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression.
Yan T, Yan N, Xia Y, Sawaswong V, Zhu X, Dias HB, Aibara D, Takahashi S, Hamada K, Saito Y, Li G, Liu H, Yan H, Velenosi TJ, Krausz KW, Huang J, Kimura S, Rotman Y, Qu A, Hao H, Gonzalez FJ. Yan T, et al. J Clin Invest. 2024 Apr 1;134(7):e166731. doi: 10.1172/JCI166731. J Clin Invest. 2024. PMID: 38557493 Free PMC article.
CEBPA is also expressed in hepatocytes and regulates glucolipid homeostasis; however, the role of hepatocyte-specific CEBPA in modulating liver fibrosis progression is largely unknown. Here, hepatic CEBPA expression was found to be decreased during MASH progr …
CEBPA is also expressed in hepatocytes and regulates glucolipid homeostasis; however, the role of hepatocyte-specific CEBPA in …
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK. Hilgendorf KI, et al. Cell. 2019 Nov 27;179(6):1289-1305.e21. doi: 10.1016/j.cell.2019.11.005. Epub 2019 Nov 21. Cell. 2019. PMID: 31761534 Free PMC article.
Age-related liver endothelial zonation triggers steatohepatitis by inactivating pericentral endothelium-derived C-kit.
Duan JL, Liu JJ, Ruan B, Ding J, Fang ZQ, Xu H, Song P, Xu C, Li ZW, Du W, Xu M, Ling YW, He F, Wang L. Duan JL, et al. Nat Aging. 2023 Mar;3(3):258-274. doi: 10.1038/s43587-022-00348-z. Epub 2022 Dec 30. Nat Aging. 2023. PMID: 37118422
Mechanistically, C-kit transcriptionally inhibits chemokine (C-X-C motif) receptor (CXCR)4 via CCAAT enhancer-binding protein alpha (CEBPA). Blocking CXCR4 signaling abolishes LSEC-macrophage-neutrophil cross-talk and leads to the recovery of C-kit-deficient mice wi …
Mechanistically, C-kit transcriptionally inhibits chemokine (C-X-C motif) receptor (CXCR)4 via CCAAT enhancer-binding protein alpha (CEBP …
C/EBPalpha regulates macrophage activation and systemic metabolism.
Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. Lee B, et al. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1144-54. doi: 10.1152/ajpendo.00002.2014. Epub 2014 Apr 1. Am J Physiol Endocrinol Metab. 2014. PMID: 24691027 Free PMC article.
Macrophage infiltration plays an important role in obesity-induced insulin resistance. CCAAT enhancer-binding protein-alpha (C/EBPalpha) is a transcription factor that is highly expressed in macrophages. ...We also found that C/EBPalpha-deficient macrophages …
Macrophage infiltration plays an important role in obesity-induced insulin resistance. CCAAT enhancer-binding protein-alpha (C/EBPalp …
The regulatory control of Cebpa enhancers and silencers in the myeloid and red-blood cell lineages.
Repele A, Krueger S, Bhattacharyya T, Tuineau MY, Manu. Repele A, et al. PLoS One. 2019 Jun 10;14(6):e0217580. doi: 10.1371/journal.pone.0217580. eCollection 2019. PLoS One. 2019. PMID: 31181110 Free PMC article.
The expression of Cebpa itself is finely modulated, as Cebpa is expressed at high and intermediate levels in neutrophils and macrophages respectively and downregulated in non-myeloid lineages. The cis-regulatory logic underlying the lineage-specific modulatio …
The expression of Cebpa itself is finely modulated, as Cebpa is expressed at high and intermediate levels in neutrophils and …
Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice.
Ko MS, Yun JY, Baek IJ, Jang JE, Hwang JJ, Lee SE, Heo SH, Bader DA, Lee CH, Han J, Moon JS, Lee JM, Hong EG, Lee IK, Kim SW, Park JY, Hartig SM, Kang UJ, Moore DD, Koh EH, Lee KU. Ko MS, et al. Autophagy. 2021 May;17(5):1205-1221. doi: 10.1080/15548627.2020.1753002. Epub 2020 May 13. Autophagy. 2021. PMID: 32400277 Free PMC article.
The ability of the nlrp3 knockouts to rescue BAT dysfunction suggests the transcriptional function of NLRP3 as an unexpected, but a quite specific therapeutic target for obesity-related metabolic diseases.Abbreviations: ACTB: actin, beta; BAPs: brown adipocyte precursors; BAT: br …
The ability of the nlrp3 knockouts to rescue BAT dysfunction suggests the transcriptional function of NLRP3 as an unexpected, but a quite sp …
The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer.
Wang A, Zheng WS, Luo Z, Bai L, Zhang S. Wang A, et al. J Transl Med. 2024 Feb 18;22(1):173. doi: 10.1186/s12967-024-04995-1. J Transl Med. 2024. PMID: 38369516 Free PMC article.
Furthermore, these factors play a role in macrophage polarization, with ZBP1 upregulated in M1 macrophages compared to both M0 and M2 polarized macrophages. We observed cg09897064 methylation in M2 polarization, but not in M0 and M1 polarized macrophages …
Furthermore, these factors play a role in macrophage polarization, with ZBP1 upregulated in M1 macrophages compared to both M0 …
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.
Avellino R, Havermans M, Erpelinck C, Sanders MA, Hoogenboezem R, van de Werken HJ, Rombouts E, van Lom K, van Strien PM, Gebhard C, Rehli M, Pimanda J, Beck D, Erkeland S, Kuiken T, de Looper H, Gröschel S, Touw I, Bindels E, Delwel R. Avellino R, et al. Blood. 2016 Jun 16;127(24):2991-3003. doi: 10.1182/blood-2016-01-695759. Epub 2016 Mar 10. Blood. 2016. PMID: 26966090 Free PMC article.
Of these, 1 enhancer located +42 kb from CEBPA is active and engages with the CEBPA promoter in myeloid cells only. Germ line deletion of the homologous enhancer in mice in vivo reduces Cebpa levels exclusively in hematopoietic stem cells (HSCs) and myeloid-p …
Of these, 1 enhancer located +42 kb from CEBPA is active and engages with the CEBPA promoter in myeloid cells only. Germ line …
Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer.
Hashimoto A, Sarker D, Reebye V, Jarvis S, Sodergren MH, Kossenkov A, Sanseviero E, Raulf N, Vasara J, Andrikakou P, Meyer T, Huang KW, Plummer R, Chee CE, Spalding D, Pai M, Khan S, Pinato DJ, Sharma R, Basu B, Palmer D, Ma YT, Evans J, Habib R, Martirosyan A, Elasri N, Reynaud A, Rossi JJ, Cobbold M, Habib NA, Gabrilovich DI. Hashimoto A, et al. Clin Cancer Res. 2021 Nov 1;27(21):5961-5978. doi: 10.1158/1078-0432.CCR-21-0986. Epub 2021 Aug 18. Clin Cancer Res. 2021. PMID: 34407972 Free PMC article. Clinical Trial.
MTL-CEBPA treatment in those patients caused a marked decrease in peripheral blood monocytic myeloid-derived suppressor cell (M-MDSC) numbers and an overall reduction in the numbers of protumoral M2 tumor-associated macrophages (TAM). ...The antitumor effects of MTL …
MTL-CEBPA treatment in those patients caused a marked decrease in peripheral blood monocytic myeloid-derived suppressor cell (M-MDSC) …
136 results