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Chronic fatigue syndrome.
Devanur LD, Kerr JR. Devanur LD, et al. Among authors: kerr jr. J Clin Virol. 2006 Nov;37(3):139-50. doi: 10.1016/j.jcv.2006.08.013. Epub 2006 Sep 15. J Clin Virol. 2006. PMID: 16978917 Free article. Review.
Chronic fatigue syndrome (CFS) is thought to have a worldwide prevalence of 0.4-1% with approximately 240,000 patients in the UK. ...But, emotional stress is distinct from depression, the presence of which precludes a diagnosis of CFS. There is no specific treatment …
Chronic fatigue syndrome (CFS) is thought to have a worldwide prevalence of 0.4-1% with approximately 240,000 patients in the UK. ... …
Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
Kerr JR. Kerr JR. Front Pediatr. 2019 Mar 13;7:59. doi: 10.3389/fped.2019.00059. eCollection 2019. Front Pediatr. 2019. PMID: 30918887 Free PMC article. Review.
The disease may be triggered by infection with a variety of micro-organisms, including Epstein-Barr virus (EBV). A subset of CFS/ME patients exhibit up regulation of EBV virus induced gene 2 (EBI2) mRNA in peripheral blood mononuclear cells (PBMC), and these patient …
The disease may be triggered by infection with a variety of micro-organisms, including Epstein-Barr virus (EBV). A subset of CFS/ME p …
Use of single-nucleotide polymorphisms (SNPs) to distinguish gene expression subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).
Shimosako N, Kerr JR. Shimosako N, et al. Among authors: kerr jr. J Clin Pathol. 2014 Dec;67(12):1078-83. doi: 10.1136/jclinpath-2014-202597. Epub 2014 Sep 19. J Clin Pathol. 2014. PMID: 25240059
AIMS: We have reported gene expression changes in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and the fact that such gene expression data can be used to identify subtypes of CFS/ME with distinct clinical phenotypes. ...CON …
AIMS: We have reported gene expression changes in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) an …
Current research priorities in chronic fatigue syndrome/myalgic encephalomyelitis: disease mechanisms, a diagnostic test and specific treatments.
Kerr JR, Christian P, Hodgetts A, Langford PR, Devanur LD, Petty R, Burke B, Sinclair LI, Richards SC, Montgomery J, McDermott CR, Harrison TJ, Kellam P, Nutt DJ, Holgate ST; Collaborative Clinical Study Group. Kerr JR, et al. J Clin Pathol. 2007 Feb;60(2):113-6. doi: 10.1136/jcp.2006.042374. Epub 2006 Aug 25. J Clin Pathol. 2007. PMID: 16935968 Free PMC article. Review.
However, we do not yet know the precise gene signature and metabolic pathways involved. Currently, this is being dealt with using a microarray representing 47,000 human genes and variants, massive parallel signature sequencing and real-time PCR. It will be important …
However, we do not yet know the precise gene signature and metabolic pathways involved. Currently, this is being dealt with using a m …
Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.
Zhang L, Gough J, Christmas D, Mattey DL, Richards SC, Main J, Enlander D, Honeybourne D, Ayres JG, Nutt DJ, Kerr JR. Zhang L, et al. Among authors: kerr jr. J Clin Pathol. 2010 Feb;63(2):156-64. doi: 10.1136/jcp.2009.072561. Epub 2009 Dec 2. J Clin Pathol. 2010. PMID: 19955554 Free PMC article.
RESULTS: In patients with CFS/ME, differential expression was confirmed for all 88 genes. Q-CFS/ME had similar patterns of gene expression to idiopathic CFS/ME. ...
RESULTS: In patients with CFS/ME, differential expression was confirmed for all 88 genes. Q-CFS/ME had similar patterns …
Pathogenesis of parvovirus B19 infection: host gene variability, and possible means and effects of virus persistence.
Kerr JR. Kerr JR. J Vet Med B Infect Dis Vet Public Health. 2005 Sep-Oct;52(7-8):335-9. doi: 10.1111/j.1439-0450.2005.00859.x. J Vet Med B Infect Dis Vet Public Health. 2005. PMID: 16316396 Review.
Interestingly, one particular single-nucleotide polymorphism (SNP) which is associated with symptomatic B19 infection occurs in the Ku80 gene which has recently been shown to be a B19 co-receptor. B19 persistence is probably the key to this phenomenon, and some new data ar …
Interestingly, one particular single-nucleotide polymorphism (SNP) which is associated with symptomatic B19 infection occurs in the Ku80 …
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.
Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST. Kerr JR, et al. J Infect Dis. 2008 Apr 15;197(8):1171-84. doi: 10.1086/533453. J Infect Dis. 2008. PMID: 18462164
We set out to determine the precise abnormalities of gene expression in the blood of patients with CFS/ME. We analyzed gene expression in peripheral blood from 25 patients with CFS/ME diagnosed according to the Centers for Disease Control and Preventio …
We set out to determine the precise abnormalities of gene expression in the blood of patients with CFS/ME. We analyzed gene
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.
Kaushik N, Fear D, Richards SC, McDermott CR, Nuwaysir EF, Kellam P, Harrison TJ, Wilkinson RJ, Tyrrell DA, Holgate ST, Kerr JR. Kaushik N, et al. Among authors: kerr jr. J Clin Pathol. 2005 Aug;58(8):826-32. doi: 10.1136/jcp.2005.025718. J Clin Pathol. 2005. PMID: 16049284 Free PMC article.
AIMS: To test the hypothesis that there are reproducible abnormalities of gene expression in patients with CFS compared with normal healthy persons. METHODS: To gain further insight into the pathogenesis of this disease, gene expression was analysed in periph …
AIMS: To test the hypothesis that there are reproducible abnormalities of gene expression in patients with CFS compared with n …
Gene profiling of patients with chronic fatigue syndrome/myalgic encephalomyelitis.
Kerr JR. Kerr JR. Curr Rheumatol Rep. 2008 Dec;10(6):482-91. doi: 10.1007/s11926-008-0079-5. Curr Rheumatol Rep. 2008. PMID: 19007540
Following two microarray studies, we reported the differential expression of 88 human genes in patients with CFS; 85 of these genes were upregulated and 3 were downregulated. ...Gene signatures in each subtype implicate five human genes as possi …
Following two microarray studies, we reported the differential expression of 88 human genes in patients with CFS; 85 of these …
Association of chronic fatigue syndrome with human leucocyte antigen class II alleles.
Smith J, Fritz EL, Kerr JR, Cleare AJ, Wessely S, Mattey DL. Smith J, et al. Among authors: kerr jr. J Clin Pathol. 2005 Aug;58(8):860-3. doi: 10.1136/jcp.2004.022681. J Clin Pathol. 2005. PMID: 16049290 Free PMC article.
RESULTS: Analysis by 2 x 2 contingency tables revealed an increased frequency of HLA-DQA1*01 alleles in patients with CFS (51.0% v 35%; odds ratio (OR), 1.93; p = 0.008). HLA-DQB1*06 was also increased in the patients with CFS (30.2% v 20.0%; OR, 1.73, p = 0.052). . …
RESULTS: Analysis by 2 x 2 contingency tables revealed an increased frequency of HLA-DQA1*01 alleles in patients with CFS (51.0% v 35 …
13 results