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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 4
1990 7
1991 19
1992 34
1993 46
1994 59
1995 57
1996 69
1997 70
1998 48
1999 59
2000 61
2001 58
2002 50
2003 42
2004 59
2005 54
2006 58
2007 52
2008 48
2009 46
2010 48
2011 51
2012 44
2013 49
2014 29
2015 38
2016 38
2017 40
2018 36
2019 38
2020 27
2021 23
2022 25
2023 19
2024 1

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1,367 results

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Page 1
Adenosine A2A receptors control generalization of contextual fear in rats.
Simões AP, Portes MAM, Lopes CR, Vanz F, Lourenço VS, Pliássova A, Gaspar IL, Silva HB, Tomé ÂR, Canas PM, Prediger RD, Cunha RA. Simões AP, et al. Transl Psychiatry. 2023 Oct 12;13(1):316. doi: 10.1038/s41398-023-02613-0. Transl Psychiatry. 2023. PMID: 37828000 Free PMC article.
We now report that A(2A)R blockade through systemic administration of the A(2A)R antagonist SCH58261 immediately after contextual fear conditioning (within the consolidation window), accelerated fear generalization. Conversely, A(2A)R activation with CGS21680 decreased fea …
We now report that A(2A)R blockade through systemic administration of the A(2A)R antagonist SCH58261 immediately after contextual fear condi …
Pericyte Dysfunction Contributes to Vascular Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats.
Lin S, Landon B, Zhang H, Jin K. Lin S, et al. Aging Dis. 2023 Aug 21. doi: 10.14336/AD.2023.0821-1. Online ahead of print. Aging Dis. 2023. PMID: 37611900
We found that rats treated with CGS21680 exhibited a significant increase in CBF at 7 and 14 days after 2VO, compared to the vehicle group. Moreover, capillary lumens beneath pericytes also increased after the CGS21680 treatment. Importantly, the treatment led to su …
We found that rats treated with CGS21680 exhibited a significant increase in CBF at 7 and 14 days after 2VO, compared to the vehicle …
Adenosine A2A Receptor Regulates microRNA-181b Expression in Aorta: Therapeutic Implications for Large-Artery Stiffness.
Akiyoshi K, Fujimori T, Fu X, Shah AP, Yamaguchi A, Steenbergen C, Santhanam L, Berkowitz D, Tuday E, Baraban JM, Das S. Akiyoshi K, et al. J Am Heart Assoc. 2023 Jul 18;12(14):e028421. doi: 10.1161/JAHA.122.028421. Epub 2023 Jul 8. J Am Heart Assoc. 2023. PMID: 37421280 Free PMC article.
We found that treatment of A7r5 cells with the A(2A)R agonist CGS21680 leads to increased association of trax with translin. Furthermore, this treatment decreases levels of pre-microRNA-181b, a target of translin/trax, and those of its downstream product, mature microRNA-1 …
We found that treatment of A7r5 cells with the A(2A)R agonist CGS21680 leads to increased association of trax with translin. Furtherm …
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension.
Bessa-Gonçalves M, Bragança B, Martins-Dias E, Vinhas A, Certal M, Rodrigues T, Ferreirinha F, Costa MA, Correia-de-Sá P, Fontes-Sousa AP. Bessa-Gonçalves M, et al. Purinergic Signal. 2024 Apr;20(2):163-179. doi: 10.1007/s11302-023-09952-z. Epub 2023 Jul 5. Purinergic Signal. 2024. PMID: 37402944 Free PMC article.
Blockage of the A(2B)AR with PSB603 (100 nM), but not of the A(2A)AR with SCH442416 (100 nM), attenuated the proliferative effect of NECA in CFs from PAH rats. The A(2A)AR agonist, CGS21680 (3 and 10 nM), was virtually devoid of effect. Overall, data suggest that adenosine …
Blockage of the A(2B)AR with PSB603 (100 nM), but not of the A(2A)AR with SCH442416 (100 nM), attenuated the proliferative effect of NECA in …
A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension.
Zhuang T, Lei Y, Chang JJ, Zhou YP, Li Y, Li YX, Yang YF, Chen MH, Meng T, Fu SM, Huang LH, Cheang WS, Cooke JP, Dong ZH, Bai YN, Ruan CC. Zhuang T, et al. Eur Heart J. 2023 Aug 1;44(29):2730-2742. doi: 10.1093/eurheartj/ehad377. Eur Heart J. 2023. PMID: 37377160
Lymphatic endothelial cell-specific A2AR knockout mice fed HSD exhibited 17 2% increase in blood pressure and 17 3% increase in Na+ content associated with decreased lymphatic density (-19 2%) compared with HSD-WT mice. A2AR activation by agonist CGS21680 increased lymphat …
Lymphatic endothelial cell-specific A2AR knockout mice fed HSD exhibited 17 2% increase in blood pressure and 17 3% increase in Na+ content …
Pharmacological Characterization of P626, a Novel Dual Adenosine A2A/A2B Receptor Antagonist, on Synaptic Plasticity and during an Ischemic-like Insult in CA1 Rat Hippocampus.
Venturini M, Cherchi F, Santalmasi C, Frulloni L, Dettori I, Catarzi D, Pedata F, Colotta V, Varano F, Coppi E, Pugliese AM. Venturini M, et al. Biomolecules. 2023 May 27;13(6):894. doi: 10.3390/biom13060894. Biomolecules. 2023. PMID: 37371474 Free PMC article.
Furthermore, the stimulation of A(2A)ARs or A(2B)ARs by respective selective agonists, CGS21680 and BAY60-6583, increases pre-synaptic neurotransmitter release, as shown by the decrease in paired-pulse facilitation (PPF) at Schaffer collateral-CA1 synapses. ...We demonstra …
Furthermore, the stimulation of A(2A)ARs or A(2B)ARs by respective selective agonists, CGS21680 and BAY60-6583, increases pre-synapti …
Combined treatment with Sigma1R and A2AR agonists fails to inhibit cocaine self-administration despite causing strong antagonistic accumbal A2AR-D2R complex interactions: the potential role of astrocytes.
Borroto-Escuela DO, Lopez-Salas A, Wydra K, Bartolini M, Zhou Z, Frankowska M, Suder A, Benitez-Porres J, Romero-Fernandez W, Filip M, Fuxe K. Borroto-Escuela DO, et al. Front Mol Neurosci. 2023 May 24;16:1106765. doi: 10.3389/fnmol.2023.1106765. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37293542 Free PMC article.
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes following cocaine self-administrat …
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R …
1,367 results