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Year Number of Results
1967 1
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1985 3
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1990 8
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2000 25
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2002 31
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2007 43
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1,369 results

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Page 1
Cri du Chat syndrome.
Cerruti Mainardi P. Cerruti Mainardi P. Orphanet J Rare Dis. 2006 Sep 5;1:33. doi: 10.1186/1750-1172-1-33. Orphanet J Rare Dis. 2006. PMID: 16953888 Free PMC article. Review.
The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). ...The cat-like cry critical region was further narrowed using quantitative polymerase chain reaction (PCR) and three candidate …
The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromos …
DDAH1 promotes neurogenesis and neural repair in cerebral ischemia.
Gao Q, Ni P, Wang Y, Huo P, Zhang X, Wang S, Xiao F, Li Y, Feng W, Yuan J, Zhang T, Li Q, Fan B, Kan Y, Li Z, Qi Y, Xing J, Yang Z, Cheng H, Gao X, Feng X, Xue M, Liu Y, Luo Y, Lu Z, Zhao Y. Gao Q, et al. Acta Pharm Sin B. 2024 May;14(5):2097-2118. doi: 10.1016/j.apsb.2024.02.001. Epub 2024 Feb 6. Acta Pharm Sin B. 2024. PMID: 38799640 Free PMC article.
However, the relevant mechanism by which ChAT(+) neurons develop in NSC niches is poorly understood. Our RNA-seq analysis revealed that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a hydrolase for asymmetric N(G),N(G)-dimethylarginine (ADMA), regulated genes r …
However, the relevant mechanism by which ChAT(+) neurons develop in NSC niches is poorly understood. Our RNA-seq analysis revealed th …
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A, Pigeonneau N, Bidnenko E, Marchadier E, Hoebeke M, Aymerich S, Becher D, Bisicchia P, Botella E, Delumeau O, Doherty G, Denham EL, Fogg MJ, Fromion V, Goelzer A, Hansen A, Härtig E, Harwood CR, Homuth G, Jarmer H, Jules M, Klipp E, Le Chat L, Lecointe F, Lewis P, Liebermeister W, March A, Mars RA, Nannapaneni P, Noone D, Pohl S, Rinn B, Rügheimer F, Sappa PK, Samson F, Schaffer M, Schwikowski B, Steil L, Stülke J, Wiegert T, Devine KM, Wilkinson AJ, van Dijl JM, Hecker M, Völker U, Bessières P, Noirot P. Nicolas P, et al. Science. 2012 Mar 2;335(6072):1103-6. doi: 10.1126/science.1206848. Science. 2012. PMID: 22383849
A Common CHAT Gene Mutation of Congenital Myasthenic Syndrome Found in Kadazandusun Children.
Tan KA, Chew HB, Yacob Y, Khoo TB. Tan KA, et al. J Pediatr Genet. 2022 Sep 15;13(3):232-236. doi: 10.1055/s-0042-1750747. eCollection 2024 Sep. J Pediatr Genet. 2022. PMID: 39086444 Free PMC article.
A rare homozygous mutation c.916G > C (p.Val306Leu) in CHAT gene was found in two siblings born of a consanguineous marriage. Third patient had compound heterozygous mutations c.406G > A (p.Val136Met) and c.916G > C (p.Val306Leu) in CHAT gene. …
A rare homozygous mutation c.916G > C (p.Val306Leu) in CHAT gene was found in two siblings born of a consanguineous marriag …
Self-injurious behavior.
Huisman S, Mulder P, Kuijk J, Kerstholt M, van Eeghen A, Leenders A, van Balkom I, Oliver C, Piening S, Hennekam R. Huisman S, et al. Neurosci Biobehav Rev. 2018 Jan;84:483-491. doi: 10.1016/j.neubiorev.2017.02.027. Epub 2017 Jul 8. Neurosci Biobehav Rev. 2018. PMID: 28694012 Free article. Review.
Each syndrome is caused by a mutation in a different gene, and this allows detection of several pathways that lead to SIB. Studying these with the behavioral consequences as specific aim will be an important step toward targeted early interventions and prevention....
Each syndrome is caused by a mutation in a different gene, and this allows detection of several pathways that lead to SIB. Studying t …
Design of a novel electrospun PVA platform for gene therapy applications using the CHAT peptide.
Mulholland EJ, McErlean EM, Dunne N, McCarthy HO. Mulholland EJ, et al. Int J Pharm. 2021 Apr 1;598:120366. doi: 10.1016/j.ijpharm.2021.120366. Epub 2021 Feb 6. Int J Pharm. 2021. PMID: 33561501
The electrospinning of polymers has previously shown excellent potential for localised gene therapy. Thus, it was proposed that for the first time, the cell-penetrating CHAT peptide could be utilised to deliver DNA via electrospun nanofibres for localised gene …
The electrospinning of polymers has previously shown excellent potential for localised gene therapy. Thus, it was proposed that for t …
Influence of a genetic variant of CHAT gene over the profile of plasma soluble ChAT in Alzheimer disease.
Rocha-Dias PF, Simao-Silva DP, Silva SSLD, Piovezan MR, Souza RKM, Darreh-Shori T, Furtado-Alle L, Souza RLR. Rocha-Dias PF, et al. Genet Mol Biol. 2020 Nov 20;43(4):e20190404. doi: 10.1590/1678-4685-GMB-2019-0404. eCollection 2020. Genet Mol Biol. 2020. PMID: 33306773 Free PMC article.
We found no significant differences in plasma levels of ChAT activity and protein between AD and EC groups. Although no differences were observed in plasma ChAT activity and protein concentration among ChEI-treated and untreated AD patients, ChAT activity and …
We found no significant differences in plasma levels of ChAT activity and protein between AD and EC groups. Although no differences w …
Human Neural Stem Cells Encoding ChAT Gene Restore Cognitive Function via Acetylcholine Synthesis, Abeta Elimination, and Neuroregeneration in APPswe/PS1dE9 Mice.
Park D, Choi EK, Cho TH, Joo SS, Kim YB. Park D, et al. Int J Mol Sci. 2020 May 31;21(11):3958. doi: 10.3390/ijms21113958. Int J Mol Sci. 2020. PMID: 32486466 Free PMC article.
We established a human neural stem cell (NSC) line encoding choline acetyltransferase (ChAT) gene, an acetylcholine-synthesizing enzyme. APPswe/PS1dE9 AD model mice transplanted with the F3.ChAT NSCs exhibited improved cognitive function and physical activity …
We established a human neural stem cell (NSC) line encoding choline acetyltransferase (ChAT) gene, an acetylcholine-synthesizi …
The cholinergic gene locus.
Eiden LE. Eiden LE. J Neurochem. 1998 Jun;70(6):2227-40. doi: 10.1046/j.1471-4159.1998.70062227.x. J Neurochem. 1998. PMID: 9603187 Review.
Messenger RNAs and the cognate gene(s) encoding choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) have been cloned from mammals and several other animal classes in the last decade. These have provided molecular tools for investigat …
Messenger RNAs and the cognate gene(s) encoding choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter ( …
Cis-regulatory elements of the cholinergic gene locus in the silkworm Bombyx mori.
Banzai K, Izumi S. Banzai K, et al. Insect Mol Biol. 2022 Feb;31(1):73-84. doi: 10.1111/imb.12739. Epub 2021 Sep 30. Insect Mol Biol. 2022. PMID: 34549831
Genes of choline acetyltransferase (ChAT) and vesicular acetylcholine transporter are encoded in the same gene locus, called the cholinergic gene locus. ...We found that dibutyryl-cAMP, an analogue of cAMP, influences the expression of ChAT in B …
Genes of choline acetyltransferase (ChAT) and vesicular acetylcholine transporter are encoded in the same gene locus, c …
1,369 results