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Year Number of Results
2003 2
2004 1
2005 1
2006 4
2007 1
2008 7
2009 7
2010 3
2011 4
2012 1
2013 1
2014 3
2016 1
2017 1
2018 2
2019 1
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Page 1
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.
Toshimitsu K, Takano A, Fujii M, Togasaki K, Matano M, Takahashi S, Kanai T, Sato T. Toshimitsu K, et al. Nat Chem Biol. 2022 Jun;18(6):605-614. doi: 10.1038/s41589-022-00984-x. Epub 2022 Mar 10. Nat Chem Biol. 2022. PMID: 35273398
A multi-omics analysis identified an association between checkpoint with forkhead and ring finger domaines (CHFR) silencing and paclitaxel sensitivity, which was further validated by gene engineering of organoids and in xenografts. ...
A multi-omics analysis identified an association between checkpoint with forkhead and ring finger domaines (CHFR) silencing and pacli …
CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer.
Hagiwara T, Sugimoto K, Momose H, Irie T, Honjo K, Okazawa YU, Kawai M, Kawano S, Munakata S, Takahashi M, Kojima Y, Serizawa N, Nagahara A, Hoffman RM, Brock MV, Sakamoto K. Hagiwara T, et al. Anticancer Res. 2022 Feb;42(2):697-707. doi: 10.21873/anticanres.15528. Anticancer Res. 2022. PMID: 35093868
MATERIALS AND METHODS: CHFR-promoter methylation was measured by quantitative methylation-specific PCR (qMSP). ...RESULTS: CHFR-promoter methylation significantly-positively correlated with inhibition of colon cancer by SN38 in the HDRA (p=0.002). ...
MATERIALS AND METHODS: CHFR-promoter methylation was measured by quantitative methylation-specific PCR (qMSP). ...RESULTS: CHFR …
Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic Colorectal Cancer.
Cha Y, Kim SY, Yeo HY, Baek JY, Choi MK, Jung KH, Dong SM, Chang HJ. Cha Y, et al. Neoplasia. 2019 Jan;21(1):146-155. doi: 10.1016/j.neo.2018.11.010. Epub 2018 Dec 15. Neoplasia. 2019. PMID: 30562637 Free PMC article.
Association between CHFR methylation and in vitro sensitivity to irinotecan was also evaluated. ...Both CHFR overexpression and combination with 5-aza-2'-deoxycytidine reversed irinotecan sensitivity in CHFR-methylated cell lines, whereas CHFR knockdow …
Association between CHFR methylation and in vitro sensitivity to irinotecan was also evaluated. ...Both CHFR overexpression an …
Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers.
Kang HC, Kim IJ, Park JH, Shin Y, Park HW, Ku JL, Yang HK, Lee KU, Choe KJ, Park JG. Kang HC, et al. Oncol Rep. 2004 Jul;12(1):129-33. Oncol Rep. 2004. PMID: 15201973
CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, whereas loss of CHFR expression has been observed in human tumors. ...A series of primary gastric tumors were also analyzed for CHFR …
CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, whereas …
A phase 2 trial of gemcitabine and docetaxel in patients with metastatic colorectal adenocarcinoma with methylated checkpoint with forkhead and ring finger domain promoter and/or microsatellite instability phenotype.
Baretti M, Karunasena E, Zahurak M, Walker R, Zhao Y, Pisanic TR 2nd, Wang TH, Greten TF, Duffy AG, Gootjes E, Meijer G, Verheul HMW, Ahuja N, Herman JG, Azad NS. Baretti M, et al. Clin Transl Sci. 2021 May;14(3):954-963. doi: 10.1111/cts.12960. Epub 2021 Apr 3. Clin Transl Sci. 2021. PMID: 33811727 Free PMC article. Clinical Trial.
We previously reported CHFR methylation in a subset of colorectal cancer (CRC; 30%) with high concordance with microsatellite instability (MSI). We also showed that CHFR methylation predicted for sensitivity to docetaxel, whereas the MSI-high phenotypes were sensiti …
We previously reported CHFR methylation in a subset of colorectal cancer (CRC; 30%) with high concordance with microsatellite instabi …
CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer.
Pelosof L, Yerram SR, Ahuja N, Delmas A, Danilova L, Herman JG, Azad NS. Pelosof L, et al. Int J Cancer. 2014 Feb 1;134(3):596-605. doi: 10.1002/ijc.28390. Epub 2013 Aug 24. Int J Cancer. 2014. PMID: 23873170 Free PMC article.
Differential sensitivity to docetaxel and gemcitabine was compared to potential predictive biomarkers CHFR methylation and MSI status. Cell lines that were MSI-H/CHFR-methylated, MSS/CHFR-methylated and MSS/CHFR-unmethylated were assessed for in vivo s …
Differential sensitivity to docetaxel and gemcitabine was compared to potential predictive biomarkers CHFR methylation and MSI status …
Aberrant methylation of the CHFR gene in digestive tract cancer.
Morioka Y, Hibi K, Sakai M, Koike M, Fujiwara M, Kodera Y, Ito K, Nakao A. Morioka Y, et al. Anticancer Res. 2006 May-Jun;26(3A):1791-5. Anticancer Res. 2006. PMID: 16827108 Free article.
The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas. ...The methylation status of the CHFR gene in 38 esophageal and 53 gastric cancers was subsequently examined and the correlation between CHFR methylation and th …
The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas. ...The methylation status of the …
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.
Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Fu Z, et al. J Clin Invest. 2009 Sep;119(9):2714-24. doi: 10.1172/JCI37405. Epub 2009 Aug 17. J Clin Invest. 2009. PMID: 19690386 Free PMC article.
Downregulation of CHFR expression was closely associated with overexpression of Aurora A, an important mitotic kinase. ...These results suggest that defects in both Chfr and Mlh1 synergistically increase predisposition to tumorigenesis....
Downregulation of CHFR expression was closely associated with overexpression of Aurora A, an important mitotic kinase. ...These resul …
The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.
Fukuda T, Kondo Y, Nakagama H. Fukuda T, et al. PLoS One. 2008 Mar 12;3(3):e1776. doi: 10.1371/journal.pone.0001776. PLoS One. 2008. PMID: 18335050 Free PMC article.
The CHFR protein comprises fork head associated- (FHA) and RING-finger (RF) domain and is frequently downregulated in human colon and gastric cancers up to 50%. The loss of CHFR mRNA expression is a consequence of promoter methylation, suggesting a tumor suppressor …
The CHFR protein comprises fork head associated- (FHA) and RING-finger (RF) domain and is frequently downregulated in human colon and …
Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk.
Kang HC, Kim IJ, Jang SG, Hong SH, Hwang JA, Shin HR, Park JG. Kang HC, et al. Cancer Lett. 2008 Feb 18;260(1-2):170-9. doi: 10.1016/j.canlet.2007.10.036. Cancer Lett. 2008. PMID: 18079053
CHFR was recently identified as an early mitotic checkpoint that delays transition to metaphase in response to mitotic stress. Although studies have shown that CHFR is relevant to tumorigenesis, no previous report has investigated whether polymorphisms in the CHF …
CHFR was recently identified as an early mitotic checkpoint that delays transition to metaphase in response to mitotic stress. Althou …
40 results