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44 results

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Page 1
Circulating Tumor DNA Methylation Is a Biomarker of Poor Recurrence-free Survival in Locally-Advanced Rectal Cancer.
Sugimoto K, Irie T, Momose H, Kochi S, Toake M, Tsuchiya Y, Tsukamoto R, Honjo K, Ishiyama S, Takahashi M, Hoffman RM, Sakamoto K. Sugimoto K, et al. Anticancer Res. 2025 Apr;45(4):1559-1573. doi: 10.21873/anticanres.17537. Anticancer Res. 2025. PMID: 40155013
Methylation analyses for checkpoint with forkhead and ring finger domains (CHFR), sex-determining region Y-box transcription factor 11 (SOX11) and cysteine dioxygenase type 1 (CDO1) used DNA extracted from plasma ctDNA at the time of resection of the primary tumor with cur …
Methylation analyses for checkpoint with forkhead and ring finger domains (CHFR), sex-determining region Y-box transcription factor 1 …
Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic Colorectal Cancer.
Cha Y, Kim SY, Yeo HY, Baek JY, Choi MK, Jung KH, Dong SM, Chang HJ. Cha Y, et al. Neoplasia. 2019 Jan;21(1):146-155. doi: 10.1016/j.neo.2018.11.010. Epub 2018 Dec 15. Neoplasia. 2019. PMID: 30562637 Free PMC article.
Association between CHFR methylation and in vitro sensitivity to irinotecan was also evaluated. Promoter methylation of CHFR, WRN, and SULF2 was identified in 16 (15.7%), 24 (23.5%), and 33 (32.4%) patients, respectively. ...Colorectal cancer cell lines with CHFR …
Association between CHFR methylation and in vitro sensitivity to irinotecan was also evaluated. Promoter methylation of CHFR, …
Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers.
Kang HC, Kim IJ, Park JH, Shin Y, Park HW, Ku JL, Yang HK, Lee KU, Choe KJ, Park JG. Kang HC, et al. Oncol Rep. 2004 Jul;12(1):129-33. Oncol Rep. 2004. PMID: 15201973
CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, whereas loss of CHFR expression has been observed in human tumors. ...A series of primary gastric tumors were also analyzed for CHFR …
CHFR is a recently identified mitotic stress check-point gene. CHFR is ubiquitously expressed in normal human tissues, whereas …
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.
Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Fu Z, et al. J Clin Invest. 2009 Sep;119(9):2714-24. doi: 10.1172/JCI37405. Epub 2009 Aug 17. J Clin Invest. 2009. PMID: 19690386 Free PMC article.
Downregulation of CHFR expression was closely associated with overexpression of Aurora A, an important mitotic kinase. ...These results suggest that defects in both Chfr and Mlh1 synergistically increase predisposition to tumorigenesis....
Downregulation of CHFR expression was closely associated with overexpression of Aurora A, an important mitotic kinase. ...These resul …
CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer.
Hagiwara T, Sugimoto K, Momose H, Irie T, Honjo K, Okazawa YU, Kawai M, Kawano S, Munakata S, Takahashi M, Kojima Y, Serizawa N, Nagahara A, Hoffman RM, Brock MV, Sakamoto K. Hagiwara T, et al. Anticancer Res. 2022 Feb;42(2):697-707. doi: 10.21873/anticanres.15528. Anticancer Res. 2022. PMID: 35093868
MATERIALS AND METHODS: CHFR-promoter methylation was measured by quantitative methylation-specific PCR (qMSP). ...RESULTS: CHFR-promoter methylation significantly-positively correlated with inhibition of colon cancer by SN38 in the HDRA (p=0.002). ...
MATERIALS AND METHODS: CHFR-promoter methylation was measured by quantitative methylation-specific PCR (qMSP). ...RESULTS: CHFR …
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.
Toshimitsu K, Takano A, Fujii M, Togasaki K, Matano M, Takahashi S, Kanai T, Sato T. Toshimitsu K, et al. Nat Chem Biol. 2022 Jun;18(6):605-614. doi: 10.1038/s41589-022-00984-x. Epub 2022 Mar 10. Nat Chem Biol. 2022. PMID: 35273398
A multi-omics analysis identified an association between checkpoint with forkhead and ring finger domaines (CHFR) silencing and paclitaxel sensitivity, which was further validated by gene engineering of organoids and in xenografts. ...
A multi-omics analysis identified an association between checkpoint with forkhead and ring finger domaines (CHFR) silencing and pacli …
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS. Corn PG, et al. Carcinogenesis. 2003 Jan;24(1):47-51. doi: 10.1093/carcin/24.1.47. Carcinogenesis. 2003. PMID: 12538348
In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. ...Methylation was associated with loss of Chfr mRNA and protein expression in cancer cell lines. In cells with methylated Chfr, tre …
In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. ...Met …
CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer.
Pelosof L, Yerram SR, Ahuja N, Delmas A, Danilova L, Herman JG, Azad NS. Pelosof L, et al. Int J Cancer. 2014 Feb 1;134(3):596-605. doi: 10.1002/ijc.28390. Epub 2013 Aug 24. Int J Cancer. 2014. PMID: 23873170 Free PMC article.
Differential sensitivity to docetaxel and gemcitabine was compared to potential predictive biomarkers CHFR methylation and MSI status. Cell lines that were MSI-H/CHFR-methylated, MSS/CHFR-methylated and MSS/CHFR-unmethylated were assessed for in vivo s …
Differential sensitivity to docetaxel and gemcitabine was compared to potential predictive biomarkers CHFR methylation and MSI status …
CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype.
Brandes JC, van Engeland M, Wouters KA, Weijenberg MP, Herman JG. Brandes JC, et al. Carcinogenesis. 2005 Jun;26(6):1152-6. doi: 10.1093/carcin/bgi058. Epub 2005 Mar 10. Carcinogenesis. 2005. PMID: 15760919
Among the 61 primary colon cancer samples studied, hypermethylation of the MLH1 and the CHFR promoter was found in 31% of the tumors. In 68% of all primary cancers (13/19) with MLH1 promoter hypermethylation, hypermethylation of the CHFR promoter was observed as wel …
Among the 61 primary colon cancer samples studied, hypermethylation of the MLH1 and the CHFR promoter was found in 31% of the tumors. …
The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.
Fukuda T, Kondo Y, Nakagama H. Fukuda T, et al. PLoS One. 2008 Mar 12;3(3):e1776. doi: 10.1371/journal.pone.0001776. PLoS One. 2008. PMID: 18335050 Free PMC article.
The CHFR protein comprises fork head associated- (FHA) and RING-finger (RF) domain and is frequently downregulated in human colon and gastric cancers up to 50%. The loss of CHFR mRNA expression is a consequence of promoter methylation, suggesting a tumor suppressor …
The CHFR protein comprises fork head associated- (FHA) and RING-finger (RF) domain and is frequently downregulated in human colon and …
44 results