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2002 1
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Page 1
CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.
Koga T, Takeshita M, Yano T, Maehara Y, Sueishi K. Koga T, et al. Int J Cancer. 2011 Mar 1;128(5):1009-17. doi: 10.1002/ijc.25447. Int J Cancer. 2011. PMID: 20473935
Aberrant promoter methylation of the checkpoint gene with forkhead-associated domain and ring finger (CHFR) gene is frequently detected in human cancer. We previously demonstrated that diminished CHFR expression was significantly correlated with both poor prognosis …
Aberrant promoter methylation of the checkpoint gene with forkhead-associated domain and ring finger (CHFR) gene is frequently detect …
CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.
Guo M, Alumkal J, Drachova T, Gao D, Marina SS, Jen J, Herman JG. Guo M, et al. Discov Med. 2015 Mar;19(104):151-8. Discov Med. 2015. PMID: 25828518 Free article.
We analyzed the DNA methylation status of eight genes (CHFR, FANCF, MGMT, p16, DAPK, ASC or TMS-1, RAR-B, and CRBP1) using nested methylation-specific PCR (MSP) on over 314 paraffin-embedded, human non-small cell lung cancer samples. ...Our methylation analysis showed freq …
We analyzed the DNA methylation status of eight genes (CHFR, FANCF, MGMT, p16, DAPK, ASC or TMS-1, RAR-B, and CRBP1) using nested met …
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS. Corn PG, et al. Carcinogenesis. 2003 Jan;24(1):47-51. doi: 10.1093/carcin/24.1.47. Carcinogenesis. 2003. PMID: 12538348
In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. ...Methylation was associated with loss of Chfr mRNA and protein expression in cancer cell lines. In cells with methylated Chfr, tre …
In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. ...Met …
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.
Pillai RN, Brodie SA, Sica GL, Shaojin Y, Li G, Nickleach DC, Yuan L, Varma VA, Bonta D, Herman JG, Brock MV, Ribeiro MJ, Ramalingam SS, Owonikoko TK, Khuri FR, Brandes JC. Pillai RN, et al. Clin Cancer Res. 2013 Mar 15;19(6):1603-11. doi: 10.1158/1078-0432.CCR-12-2995. Epub 2013 Feb 5. Clin Cancer Res. 2013. PMID: 23386692 Free PMC article.
RESULTS: High expression (score = 4) of CHFR is strongly associated with adverse outcomes: the risk for progressive disease after first-line chemotherapy with carboplatin-paclitaxel was 52% in patients with CHFR-high versus only 19% in those with CHFR-low tum …
RESULTS: High expression (score = 4) of CHFR is strongly associated with adverse outcomes: the risk for progressive disease after fir …
CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes.
Takeshita M, Koga T, Takayama K, Kouso H, Nishimura-Ikeda Y, Yoshino I, Maehara Y, Nakanishi Y, Sueishi K. Takeshita M, et al. Int J Cancer. 2008 Oct 1;123(7):1623-30. doi: 10.1002/ijc.23673. Int J Cancer. 2008. PMID: 18623126
The relationship between CHFR protein and mRNA levels and the association between this relationship and promoter methylation of the CHFR gene were also examined in 20 frozen sections of NSCLC. ...Multivariate analysis revealed that CHFR expression was an inde …
The relationship between CHFR protein and mRNA levels and the association between this relationship and promoter methylation of the …
WHO grading system for invasive pulmonary lung adenocarcinoma reveals distinct molecular signature: An analysis from the cancer genome atlas database.
Forest F, Laville D, Da Cruz V, Casteillo F, Clemenson A, Yvorel V, Picot T. Forest F, et al. Exp Mol Pathol. 2022 Apr;125:104756. doi: 10.1016/j.yexmp.2022.104756. Epub 2022 Mar 23. Exp Mol Pathol. 2022. PMID: 35339455
SCGB1A1 mRNA expression was higher in grade 2 (p = 0.0179) whereas NUP155, CHFR, POLQ and CDC7 have a higher expression in grade 3 (p = 0.0189, 0.0427, 0.0427 and 0.427 respectively). ...
SCGB1A1 mRNA expression was higher in grade 2 (p = 0.0179) whereas NUP155, CHFR, POLQ and CDC7 have a higher expression in grade 3 (p …
CHFR aberrant methylation involves a subset of human lung adenocarcinoma associated with poor clinical outcomes.
Koga T, Takeshita M, Ijichi K, Yano T, Maehara Y, Sueishi K. Koga T, et al. Hum Pathol. 2013 Jul;44(7):1382-90. doi: 10.1016/j.humpath.2012.11.008. Epub 2013 Feb 14. Hum Pathol. 2013. PMID: 23415374
EGFR mutations occurred in patients who were negative for both CHFR hypermethylation and KRAS mutation. Among the 4 genetic or epigenetic abnormalities, only CHFR hypermethylation was significantly correlated with poor prognosis and lymphatic vessel invasion (P = .0 …
EGFR mutations occurred in patients who were negative for both CHFR hypermethylation and KRAS mutation. Among the 4 genetic or epigen …
Molecular characteristics of non-small cell lung cancer with reduced CHFR expression in The Cancer Genome Atlas (TCGA) project.
Brodie SA, Li G, Brandes JC. Brodie SA, et al. Respir Med. 2015 Jan;109(1):131-6. doi: 10.1016/j.rmed.2014.11.004. Epub 2014 Nov 21. Respir Med. 2015. PMID: 25477232 Free PMC article.
BACKGROUND: CHFR expression has previously been established as a powerful predictor for response to taxane based first-line chemotherapy in non-small cell lung cancer. It is currently unknown however, if reduced CHFR expression correlates with certain molecular subt …
BACKGROUND: CHFR expression has previously been established as a powerful predictor for response to taxane based first-line chemother …
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small-cell lung cancer.
Takeshita M, Koga T, Takayama K, Yano T, Maehara Y, Nakanishi Y, Sueishi K. Takeshita M, et al. Cancer Biol Ther. 2010 Nov 1;10(9):933-41. doi: 10.4161/cbt.10.9.13320. Epub 2010 Nov 1. Cancer Biol Ther. 2010. PMID: 20855974 Free article.
Experiments using cancer cell lines have revealed that CHFR methylation correlates with sensitivity to microtubule inhibitors. However, this marker may not benefit actual clinical cases because it is difficult to detect CHFR methylation without surgically resected s …
Experiments using cancer cell lines have revealed that CHFR methylation correlates with sensitivity to microtubule inhibitors. Howeve …
13 results