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2002 1
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Page 1
CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.
Koga T, Takeshita M, Yano T, Maehara Y, Sueishi K. Koga T, et al. Int J Cancer. 2011 Mar 1;128(5):1009-17. doi: 10.1002/ijc.25447. Int J Cancer. 2011. PMID: 20473935 Free article.
CHFR hypermethylation and EGFR mutation were mutually exclusive (p = 0.004). ...Thus, CHFR alteration should be considered a therapeutic target against NSCLC in patients with poor prognoses....
CHFR hypermethylation and EGFR mutation were mutually exclusive (p = 0.004). ...Thus, CHFR alteration should be considered a t …
CHFR aberrant methylation involves a subset of human lung adenocarcinoma associated with poor clinical outcomes.
Koga T, Takeshita M, Ijichi K, Yano T, Maehara Y, Sueishi K. Koga T, et al. Hum Pathol. 2013 Jul;44(7):1382-90. doi: 10.1016/j.humpath.2012.11.008. Epub 2013 Feb 14. Hum Pathol. 2013. PMID: 23415374
EGFR mutations occurred in patients who were negative for both CHFR hypermethylation and KRAS mutation. Among the 4 genetic or epigenetic abnormalities, only CHFR hypermethylation was significantly correlated with poor prognosis and lymphatic vessel invasion (P = .0 …
EGFR mutations occurred in patients who were negative for both CHFR hypermethylation and KRAS mutation. Among the 4 genetic or epigen …
CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.
Pillai RN, Brodie SA, Sica GL, Shaojin Y, Li G, Nickleach DC, Yuan L, Varma VA, Bonta D, Herman JG, Brock MV, Ribeiro MJ, Ramalingam SS, Owonikoko TK, Khuri FR, Brandes JC. Pillai RN, et al. Clin Cancer Res. 2013 Mar 15;19(6):1603-11. doi: 10.1158/1078-0432.CCR-12-2995. Epub 2013 Feb 5. Clin Cancer Res. 2013. PMID: 23386692 Free PMC article.
RESULTS: High expression (score = 4) of CHFR is strongly associated with adverse outcomes: the risk for progressive disease after first-line chemotherapy with carboplatin-paclitaxel was 52% in patients with CHFR-high versus only 19% in those with CHFR-low tum …
RESULTS: High expression (score = 4) of CHFR is strongly associated with adverse outcomes: the risk for progressive disease after fir …
CHFR expression is preferentially impaired in smoking-related squamous cell carcinoma of the lung, and the diminished expression significantly harms outcomes.
Takeshita M, Koga T, Takayama K, Kouso H, Nishimura-Ikeda Y, Yoshino I, Maehara Y, Nakanishi Y, Sueishi K. Takeshita M, et al. Int J Cancer. 2008 Oct 1;123(7):1623-30. doi: 10.1002/ijc.23673. Int J Cancer. 2008. PMID: 18623126 Free article.
The relationship between CHFR protein and mRNA levels and the association between this relationship and promoter methylation of the CHFR gene were also examined in 20 frozen sections of NSCLC. ...Multivariate analysis revealed that CHFR expression was an inde …
The relationship between CHFR protein and mRNA levels and the association between this relationship and promoter methylation of the …
CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.
Guo M, Alumkal J, Drachova T, Gao D, Marina SS, Jen J, Herman JG. Guo M, et al. Discov Med. 2015 Mar;19(104):151-8. Discov Med. 2015. PMID: 25828518 Free article.
Our methylation analysis showed frequencies of methylation of 10% for CHFR, 14% for FANCF, 30% for MGMT, 29% for p16, 17% for DAPK, 33% for ASC, 38% for RAR-B, and 7% for CRBP1. There was a strong correlation between methylation of the mitotic G2-M checkpoint gene, CHFR …
Our methylation analysis showed frequencies of methylation of 10% for CHFR, 14% for FANCF, 30% for MGMT, 29% for p16, 17% for DAPK, 3 …
Molecular characteristics of non-small cell lung cancer with reduced CHFR expression in The Cancer Genome Atlas (TCGA) project.
Brodie SA, Li G, Brandes JC. Brodie SA, et al. Respir Med. 2015 Jan;109(1):131-6. doi: 10.1016/j.rmed.2014.11.004. Epub 2014 Nov 21. Respir Med. 2015. PMID: 25477232 Free PMC article.
It is currently unknown however, if reduced CHFR expression correlates with certain molecular subtypes of lung cancer. PURPOSE: In order to determine which patients may benefit from CHFR biomarker testing we conducted the present study to characterize clinical and m …
It is currently unknown however, if reduced CHFR expression correlates with certain molecular subtypes of lung cancer. PURPOSE: In or …
Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers.
Mizuno K, Osada H, Konishi H, Tatematsu Y, Yatabe Y, Mitsudomi T, Fujii Y, Takahashi T. Mizuno K, et al. Oncogene. 2002 Apr 4;21(15):2328-33. doi: 10.1038/sj.onc.1205402. Oncogene. 2002. PMID: 11948416
In this study, we demonstrated tumor-specific aberrant hypermethylation of the promoter region of the CHFR gene in a significant fraction of lung cancers in association with loss of detectable levels of CHFR transcripts. ...Treatment with the demethylating agent 5-a …
In this study, we demonstrated tumor-specific aberrant hypermethylation of the promoter region of the CHFR gene in a significant frac …
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS. Corn PG, et al. Carcinogenesis. 2003 Jan;24(1):47-51. doi: 10.1093/carcin/24.1.47. Carcinogenesis. 2003. PMID: 12538348
In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. ...Methylation was associated with loss of Chfr mRNA and protein expression in cancer cell lines. In cells with methylated Chfr, tre …
In addition, Chfr was methylated in 37% of primary colon adenocarcinomas and in 10% of primary non-small cell lung carcinomas. ...Met …
Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small-cell lung cancer.
Takeshita M, Koga T, Takayama K, Yano T, Maehara Y, Nakanishi Y, Sueishi K. Takeshita M, et al. Cancer Biol Ther. 2010 Nov 1;10(9):933-41. doi: 10.4161/cbt.10.9.13320. Epub 2010 Nov 1. Cancer Biol Ther. 2010. PMID: 20855974 Free article.
Experiments using cancer cell lines have revealed that CHFR methylation correlates with sensitivity to microtubule inhibitors. ...The SDI method revealed that CHFR gene methylation was significantly related to high sensitivity to paclitaxel (p....
Experiments using cancer cell lines have revealed that CHFR methylation correlates with sensitivity to microtubule inhibitors. ...The …
WHO grading system for invasive pulmonary lung adenocarcinoma reveals distinct molecular signature: An analysis from the cancer genome atlas database.
Forest F, Laville D, Da Cruz V, Casteillo F, Clemenson A, Yvorel V, Picot T. Forest F, et al. Exp Mol Pathol. 2022 Apr;125:104756. doi: 10.1016/j.yexmp.2022.104756. Epub 2022 Mar 23. Exp Mol Pathol. 2022. PMID: 35339455
SCGB1A1 mRNA expression was higher in grade 2 (p = 0.0179) whereas NUP155, CHFR, POLQ and CDC7 have a higher expression in grade 3 (p = 0.0189, 0.0427, 0.0427 and 0.427 respectively). ...
SCGB1A1 mRNA expression was higher in grade 2 (p = 0.0179) whereas NUP155, CHFR, POLQ and CDC7 have a higher expression in grade 3 (p …
13 results