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Encouraging student-driven clinical research in Germany: the CHIR-Net SIGMA network.
Frey PE, Friedrich M, Rädeker L, Fink CA, Leuck A, Tenckhoff S, Neudecker J, Mihaljevic AL. Frey PE, et al. Innov Surg Sci. 2017 Nov 27;2(4):255-260. doi: 10.1515/iss-2017-0038. eCollection 2017 Dec. Innov Surg Sci. 2017. PMID: 31579759 Free PMC article. Review.
Although this has been significantly improved after the establishment of the Study Center of the German Surgical Society (SDGC) and the surgical clinical trial network CHIR-Net, limited focus has been put on the training, teaching, and recruitment of medical student …
Although this has been significantly improved after the establishment of the Study Center of the German Surgical Society (SDGC) and the surg …
Postoperative Complications and Mobilization Following Major Abdominal Surgery With Versus Without Fitness Tracker-based Feedback (EXPELLIARMUS): A Student-led Multicenter Randomized Controlled Clinical Trial of the CHIR-Net SIGMA Study Group.
Mihaljevic AL; CHIR-Net SIGMA Study Group. Mihaljevic AL, et al. Ann Surg. 2024 Aug 1;280(2):202-211. doi: 10.1097/SLA.0000000000006232. Epub 2024 Feb 9. Ann Surg. 2024. PMID: 38984800 Free PMC article. Clinical Trial.
METHODS: EXPELLIARMUS was performed at 11 University Hospitals across Germany by the student-led clinical trial network SIGMA. Patients undergoing major abdominal surgery were enrolled, equipped with an FT, and randomly assigned to the experimental (visible screen) or cont …
METHODS: EXPELLIARMUS was performed at 11 University Hospitals across Germany by the student-led clinical trial network SIGMA. Patien …
Prospective multicentre cohort study of patient-reported outcomes and complications following major abdominal neoplastic surgery (PATRONUS) - study protocol for a CHIR-Net student-initiated German medical audit study (CHIR-Net SIGMA study).
Fink CA, Friedrich M, Frey PE, Rädeker L, Leuck A, Bruckner T, Feisst M, Tenckhoff S, Klose C, Dörr-Harim C, Neudecker J, Mihaljevic AL. Fink CA, et al. BMC Surg. 2018 Oct 29;18(1):90. doi: 10.1186/s12893-018-0422-3. BMC Surg. 2018. PMID: 30373596 Free PMC article.
Patients undergoing elective oncological abdominal surgery will be recruited at regional centres of the clinical network of the German Surgical Society (CHIR-Net) and associated hospitals. A core set of 12 cancer associated symptoms will be assessed via the PRO vers …
Patients undergoing elective oncological abdominal surgery will be recruited at regional centres of the clinical network of the German Surgi …
Postoperative complications and mobilisation following major abdominal surgery with vs. without fitness tracker-based feedback (EXPELLIARMUS): study protocol for a student-led multicentre randomised controlled trial (CHIR-Net SIGMA study group).
Schwab M, Brindl N, Studier-Fischer A, Tu T, Gsenger J, Pilgrim M, Friedrich M, Frey PE, Achilles C, Leuck A, Bürgel T, Feisst M, Klose C, Tenckhoff S, Dörr-Harim C, Mihaljevic AL. Schwab M, et al. Trials. 2020 Mar 23;21(1):293. doi: 10.1186/s13063-020-4220-8. Trials. 2020. PMID: 32293519 Free PMC article.
The study will be conducted and organised by the student-led German Clinical Trial Network SIGMA. DISCUSSION: Our study aims at investigating whether the implementation of a simple mobilisation protocol in combination with FT-based feedback can reduce postoperative morbidi …
The study will be conducted and organised by the student-led German Clinical Trial Network SIGMA. DISCUSSION: Our study aims at inves …
Postoperative Complications and Mobilization Following Major Abdominal Surgery With Versus Without Fitness Tracker-based Feedback (EXPELLIARMUS); A Student-led Multicenter Randomized Controlled Clinical Trial of the CHIR-Net SIGMA Study Group: Erratum.
Mihaljevic AL; CHIR-Net SIGMA Study Group. Mihaljevic AL, et al. Ann Surg. 2025 Jun 1;281(6):e6. doi: 10.1097/SLA.0000000000006727. Epub 2025 May 12. Ann Surg. 2025. PMID: 40358005 Free PMC article. No abstract available.
[Design and Evaluation of a Clinical Investigator Training for Student-lead Prospective Multicentre Clinical Trials: a CHIR-Net SIGMA Research-based Learning Project].
Rädeker L, Schwab M, Frey PE, Friedrich M, Sliwinski S, Steinle J, Fink CA, Leuk A, Ganschow P, Ottawa GB, Klose C, Feißt M, Dörr-Harim C, Tenckhoff S, Mihaljevic AL. Rädeker L, et al. Zentralbl Chir. 2020 Dec;145(6):521-530. doi: 10.1055/a-1007-1995. Epub 2019 Oct 28. Zentralbl Chir. 2020. PMID: 31658485 German.
In order to counter this problem, the surgical study network (CHIR-Net) founded SIGMA (Student-initiated German Medical Audit). This paper describes the development, performance and evaluation of a Clinical Investigator Training (CIT) aiming to qualify studen …
In order to counter this problem, the surgical study network (CHIR-Net) founded SIGMA (Student-initiated German Medical …
Multicenter Prospective Cohort Study of the Patient-Reported Outcome Measures PRO-CTCAE and CAT EORTC QLQ-C30 in Major Abdominal Cancer Surgery (PATRONUS): A Student-Initiated German Medical Audit (SIGMA) Study.
CHIR-Net SIGMA Study Group*; Mihaljevic AL. CHIR-Net SIGMA Study Group*, et al. Ann Surg Oncol. 2021 Jun;28(6):3075-3089. doi: 10.1245/s10434-021-09646-z. Epub 2021 Mar 8. Ann Surg Oncol. 2021. PMID: 33683524 Free PMC article.
The study was carried out by medical students of the CHIR-Net SIGMA study network. RESULTS: Data of 303 patients were obtained and analyzed across 15 sites. ...
The study was carried out by medical students of the CHIR-Net SIGMA study network. RESULTS: Data of 303 patients were o …