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Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Teichman SL, et al. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. J Clin Endocrinol Metab. 2006. PMID: 16352683 Clinical Trial.
The estimated half-life of CJC-1295 was 5.8-8.1 d. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. ...These data support the potential utility of CJC-1295 as a therapeutic agent....
The estimated half-life of CJC-1295 was 5.8-8.1 d. After multiple CJC-1295 doses, mean IGF-I levels remained abo …
Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.
Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Sackmann-Sala L, et al. Growth Horm IGF Res. 2009 Dec;19(6):471-7. doi: 10.1016/j.ghir.2009.03.001. Epub 2009 Apr 21. Growth Horm IGF Res. 2009. PMID: 19386527 Free PMC article.
OBJECTIVE: To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in human serum. BACKGROUND: The search for new markers of GH activity has received extensive attention given that the current biomarkers ( …
OBJECTIVE: To identify biomarkers of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) action in huma …
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.
Ionescu M, Frohman LA. Ionescu M, et al. J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7. doi: 10.1210/jc.2006-1702. Epub 2006 Oct 3. J Clin Endocrinol Metab. 2006. PMID: 17018654 Clinical Trial.
RESULTS: GH secretion was increased after CJC-1295 administration with preserved pulsatility. ...The IGF-I increases did not correlate with any parameters of GH secretion. CONCLUSIONS: CJC-1295 increased trough and mean GH secretio …
RESULTS: GH secretion was increased after CJC-1295 administration with preserved pulsatility. ...The IGF-I increases di …
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Dominikowski A, Rękoś Z, Olejarz M, Szczepanek-Parulska E, Domin R, RuchaŁa M. Dominikowski A, et al. Front Endocrinol (Lausanne). 2026 Jun 18;17:1822475. doi: 10.3389/fendo.2026.1822475. eCollection 2026. Front Endocrinol (Lausanne). 2026. PMID: 42395176 Free PMC article. Review.
Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis. The agents most commonly encountered in clinical practice and online self-ad …
Performance-enhancing drugs (PEDs) marketed as "research compounds" include unregulated peptides intended to modulate the growth hormone-ins …
Immunoaffinity purification of peptide hormones prior to liquid chromatography-mass spectrometry in doping controls.
Thomas A, Schänzer W, Delahaut P, Thevis M. Thomas A, et al. Methods. 2012 Feb;56(2):230-5. doi: 10.1016/j.ymeth.2011.08.009. Epub 2011 Aug 18. Methods. 2012. PMID: 21871962 Review.
With the presented methodology 12 prohibited peptides (porcine insulin, Novolog, Apidra, Lantus DesB30-32 metabolite, Humalog and human insulin, Synacthen (synthetic ACTH analogue), luteinizing hormone-releasing hormone (LH-RH), growth hormone releasing hormone (GH-RH(1-29 …
With the presented methodology 12 prohibited peptides (porcine insulin, Novolog, Apidra, Lantus DesB30-32 metabolite, Humalog and human insu …
Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth.
Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Gautam D, et al. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403. doi: 10.1073/pnas.0900977106. Epub 2009 Mar 30. Proc Natl Acad Sci U S A. 2009. PMID: 19332789 Free PMC article.
We report the surprising observation that mutant mice that selectively lack the M(3) muscarinic acetylcholine receptor subtype in the brain (neurons and glial cells; Br-M3-KO mice) showed a dwarf phenotype associated with a pronounced hypoplasia of the anterior pituitary gland an …
We report the surprising observation that mutant mice that selectively lack the M(3) muscarinic acetylcholine receptor subtype in the brain …