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1,175 results

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Page 1
COL1A1: A novel oncogenic gene and therapeutic target in malignancies.
Li X, Sun X, Kan C, Chen B, Qu N, Hou N, Liu Y, Han F. Li X, et al. Pathol Res Pract. 2022 Aug;236:154013. doi: 10.1016/j.prp.2022.154013. Epub 2022 Jul 5. Pathol Res Pract. 2022. PMID: 35816922 Review.
COL1A1 is also associated with cancer progression and prognosis; elevated COL1A1 expression is associated with poor prognosis in cancer patients. ...This review discusses current research progress concerning COL1A1 in different tumor types, and …
COL1A1 is also associated with cancer progression and prognosis; elevated COL1A1 expression is associated with poor pro …
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer.
Choi JH, Lee BS, Jang JY, Lee YS, Kim HJ, Roh J, Shin YS, Woo HG, Kim CH. Choi JH, et al. Nat Commun. 2023 Feb 24;14(1):1055. doi: 10.1038/s41467-023-36691-x. Nat Commun. 2023. PMID: 36828832 Free PMC article.
We also demonstrate the interdependent ligand-receptor interaction of COL1A1 and CD44 between fibroblasts and malignant cells, facilitating HNSCC progression. ...
We also demonstrate the interdependent ligand-receptor interaction of COL1A1 and CD44 between fibroblasts and malignant cells, facili …
FEATURES OF COL1A1 EXPRESSION IN BREAST CANCER TISSUE OF YOUNG PATIENTS.
Chekhun V, Mushii O, Zadvornyi T, Borikun T, Martyniuk О, Kashuba E, Kryzhanivska A, Andriiv A, Diakiv I, Lukianova N. Chekhun V, et al. Exp Oncol. 2023 Dec 28;45(3):351-363. doi: 10.15407/exp-oncology.2023.03.351. Exp Oncol. 2023. PMID: 38186020

RESULTS: The bioinformatic analysis showed that BCa tissue is characterized by 6.0 times (p < 0.05) higher level of COL1A1 mRNA compared to normal breast tissue. The correlation of COL1A1 expression at the mRNA and protein levels with the molecular subtype of

…

RESULTS: The bioinformatic analysis showed that BCa tissue is characterized by 6.0 times (p < 0.05) higher level of COL1A1 mRNA co

…
RhoBTB3 Regulates Proliferation and Invasion of Breast Cancer Cells via Col1a1.
Kim K, Kim YJ. Kim K, et al. Mol Cells. 2022 Sep 30;45(9):631-639. doi: 10.14348/molcells.2022.2037. Epub 2022 Jun 14. Mol Cells. 2022. PMID: 35698915 Free PMC article.
Further, Col1a1 knockdown in breast cancer cells limited the proliferative and invasive ability of cancer cells. Knockdown of RhoBTB3 may exert inhibit the proliferation, migration, and metastasis of breast cancer cells by repressing the expression of …
Further, Col1a1 knockdown in breast cancer cells limited the proliferative and invasive ability of cancer cells. Knockd …
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
Blanc V, Riordan JD, Soleymanjahi S, Nadeau JH, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng IO, Ha Y, Roberts LR, Davidson NO. Blanc V, et al. J Clin Invest. 2021 Jan 4;131(1):e138699. doi: 10.1172/JCI138699. J Clin Invest. 2021. PMID: 33445170 Free PMC article.
Here we studied hepatocyte-specific A1cf-transgenic (A1cf+/Tg), A1cf+/Tg Apobec1-/-, and A1cf-/- mice fed chow or high-fat/high-fructose diets using RNA-Seq, RNA CLIP-Seq, and tissue microarrays from human hepatocellular cancer (HCC). A1cf+/Tg mice exhibited increased hepa …
Here we studied hepatocyte-specific A1cf-transgenic (A1cf+/Tg), A1cf+/Tg Apobec1-/-, and A1cf-/- mice fed chow or high-fat/high-fructose die …
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1-targeting miRNA-92a-1-5p.
Yu L, Sui B, Fan W, Lei L, Zhou L, Yang L, Diao Y, Zhang Y, Li Z, Liu J, Hao X. Yu L, et al. J Extracell Vesicles. 2021 Jan;10(3):e12056. doi: 10.1002/jev2.12056. Epub 2021 Jan 18. J Extracell Vesicles. 2021. PMID: 33489015 Free PMC article.
In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs; however, pathological fractures frequently occur in PCa patients, and bone resorption is observed in all metastatic lesions under histopathologic assessment. ...Among the delivered miR …
In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs; however, pathological fractures frequently o …
Voluntary exercise sensitizes cancer immunotherapy via the collagen inhibition-orchestrated inflammatory tumor immune microenvironment.
Luo Z, Mei J, Wang X, Wang R, He Z, Geffen Y, Sun X, Zhang X, Xu J, Wan R, Feng X, Jiao C, Su X, Sun J, Chen S, Chen J, Mao W, Yang Y, Sun Y. Luo Z, et al. Cell Rep. 2024 Sep 24;43(9):114697. doi: 10.1016/j.celrep.2024.114697. Epub 2024 Aug 31. Cell Rep. 2024. PMID: 39217611 Free article.
Physical activity reduces cancer-associated mortality through multiple mechanisms, including tumor immune microenvironment (TIME) reprogramming. ...Our work reveals the predictive value of miR-29a-3p for immunotherapy, provides mechanistic insights into exercise-induced an …
Physical activity reduces cancer-associated mortality through multiple mechanisms, including tumor immune microenvironment (TIME) rep …
Expression, prognostic value and potential immunotherapeutic target of COL1A1 in colon cancer.
Zeng X, Chen G, Guo D, Chen Y, Hu X. Zeng X, et al. Cell Mol Biol (Noisy-le-grand). 2023 Dec 31;69(15):120-125. doi: 10.14715/cmb/2023.69.15.21. Cell Mol Biol (Noisy-le-grand). 2023. PMID: 38279475
Correlation analysis was implemented to study the causal relationship between COL1A1 and immune checkpoint molecules and inflammation immune cell infiltration. Results showed that in colorectal cancer, COL1A1 was highly expressed and linked with a few clinico …
Correlation analysis was implemented to study the causal relationship between COL1A1 and immune checkpoint molecules and inflammation …
RUNX2 promotes malignant progression in gastric cancer by regulating COL1A1.
Li Y, Sun R, Zhao X, Sun B. Li Y, et al. Cancer Biomark. 2021;31(3):227-238. doi: 10.3233/CBM-200472. Cancer Biomark. 2021. PMID: 33896817 Free article.
RESULTS: RUNX2 and COL1A1 were highly expressed at both the gene and protein levels in GC, and patients who were positive for RUNX2 and COL1A1 had shorter survival. ...RUNX2/COL1A1 can be employed as a novel target for therapy in GC....
RESULTS: RUNX2 and COL1A1 were highly expressed at both the gene and protein levels in GC, and patients who were positive for RUNX2 a …
Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer.
Ucaryilmaz Metin C, Ozcan G. Ucaryilmaz Metin C, et al. BMC Cancer. 2022 Jun 23;22(1):692. doi: 10.1186/s12885-022-09736-5. BMC Cancer. 2022. PMID: 35739492 Free PMC article.
BACKGROUND: Gastric cancer is one of the deadliest cancers, currently available therapies have limited success. ...Lastly, we conducted a database search for drugs targeting the signature genes. RESULTS: Our study revealed the COL1A1, COL1A2, COL3A1, COL5A1, …
BACKGROUND: Gastric cancer is one of the deadliest cancers, currently available therapies have limited success. ...Lastly, we …
1,175 results