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Effect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial.
Castells A, Quintero E, Bujanda L, Castán-Cameo S, Cubiella J, Díaz-Tasende J, Lanas Á, Ono A, Serra-Burriel M, Frías-Arrocha E, Hernández C, Jover R, Andreu M, Carballo F, Morillas JD, Salas D, Almazán R, Alonso-Abreu I, Banales JM, Hernández V, Portillo I, Vanaclocha-Espí M, de la Vega M; COLONPREV study investigators. Castells A, et al. Lancet. 2025 Apr 12;405(10486):1231-1239. doi: 10.1016/S0140-6736(25)00145-X. Epub 2025 Mar 27. Lancet. 2025. PMID: 40158525 Clinical Trial.
In this trial, we aimed to compare whether invitation to screening with faecal immunochemical test was non-inferior to colonoscopy in a screening programme. METHODS: COLONPREV was a pragmatic, randomised, controlled, non-inferiority trial done at 15 tertiary hospitals acro …
In this trial, we aimed to compare whether invitation to screening with faecal immunochemical test was non-inferior to colonoscopy in a scre …
Detection of serrated lesions in proximal colon by simulated sigmoidoscopy vs faecal immunochemical testing in a multicentre, pragmatic, randomised controlled trial.
Carot L, Castells A, Hernández C, Alvarez-Urturi C, Balaguer F, Lanas A, Cubiella J, Tasende JD, Jover R, Hernandez V, Carballo F, Bujanda L, Quintero E, Andreu M, Bessa X. Carot L, et al. United European Gastroenterol J. 2018 Dec;6(10):1527-1537. doi: 10.1177/2050640618804722. Epub 2018 Sep 26. United European Gastroenterol J. 2018. PMID: 30574323 Free PMC article.
AIM: We determined the detection rate of proximal serrated polyps by simulated sigmoidoscopy and faecal immunochemical test compared with total colonoscopy in a population-based, multicentre, nationwide, randomised controlled trial (ColonPrev study). METHODS: Sigmoidoscopy …
AIM: We determined the detection rate of proximal serrated polyps by simulated sigmoidoscopy and faecal immunochemical test compared with to …
Importance of endoscopist quality metrics for findings at surveillance colonoscopy: The detection-surveillance paradox.
Mangas-Sanjuan C, Zapater P, Cubiella J, Murcia Ó, Bujanda L, Hernández V, Martínez-Ares D, Pellisé M, Seoane A, Lanas Á, Nicolás-Pérez D, Herreros-de-Tejada A, Chaparro M, Cacho G, Fernández-Díez S, Marín-Gabriel JC, Quintero E, Castells A, Jover R; COLONPREV study investigators. Mangas-Sanjuan C, et al. United European Gastroenterol J. 2018 May;6(4):622-629. doi: 10.1177/2050640617745458. Epub 2017 Nov 24. United European Gastroenterol J. 2018. PMID: 29881618 Free PMC article.
Correlation between adenoma detection rate in colonoscopy- and fecal immunochemical testing-based colorectal cancer screening programs.
Cubiella J, Castells A, Andreu M, Bujanda L, Carballo F, Jover R, Lanas Á, Morillas JD, Salas D, Quintero E; COLONPREV study investigators. Cubiella J, et al. United European Gastroenterol J. 2017 Mar;5(2):255-260. doi: 10.1177/2050640616660662. Epub 2016 Jul 20. United European Gastroenterol J. 2017. PMID: 28344793 Free PMC article.
The ADR recommended in fecal immunochemical testing (FIT)-based colorectal cancer screening programs is unknown. METHODS: Using the COLONPREV (NCT00906997) study dataset, we performed a post-hoc analysis to determine if there was a correlation between the ADR in primary an …
The ADR recommended in fecal immunochemical testing (FIT)-based colorectal cancer screening programs is unknown. METHODS: Using the COLON …
Incidence of advanced neoplasia during surveillance in high- and intermediate-risk groups of the European colorectal cancer screening guidelines.
Cubiella J, Carballo F, Portillo I, Cruzado Quevedo J, Salas D, Binefa G, Milà N, Hernández C, Andreu M, Terán Á, Arana-Arri E, Ono A, Valverde MJ, Bujanda L, Hernández V, Morillas JD, Jover R, Castells A. Cubiella J, et al. Endoscopy. 2016 Nov;48(11):995-1002. doi: 10.1055/s-0042-112571. Epub 2016 Aug 2. Endoscopy. 2016. PMID: 27485482
Patients and methods: This retrospective group study included patients meeting high- or intermediate-risk criteria for adenomas detected in CRC screening programs and the COLONPREV study before European guidelines were adopted in Spain (June 2011) with a 3-year surveillanc …
Patients and methods: This retrospective group study included patients meeting high- or intermediate-risk criteria for adenomas detected in …
Impact of age- and gender-specific cut-off values for the fecal immunochemical test for hemoglobin in colorectal cancer screening.
Alvarez-Urturi C, Andreu M, Hernandez C, Perez-Riquelme F, Carballo F, Ono A, Cruzado J, Cubiella J, Hernandez V, Mao CG, Perez E, Salas D, Andrés M, Bujanda L, Portillo I, Sarasqueta C, Quintero E, Morillas JD, Lanas A, Sostres C, Augé JM, Castells A, Bessa X; COLONPREV study investigators. Alvarez-Urturi C, et al. Dig Liver Dis. 2016 May;48(5):542-551. doi: 10.1016/j.dld.2016.02.001. Epub 2016 Feb 9. Dig Liver Dis. 2016. PMID: 26936343
METHODS: CRC detection rate (DR), and analysis of resources were evaluated retrospectively, at different cut-offs of FIT (20, 25, 30, 35 and 40mug Hb/g) respect to a reference value (15mug Hb/g), according to age and gender, in a screening population of 10,611 participants of the …
METHODS: CRC detection rate (DR), and analysis of resources were evaluated retrospectively, at different cut-offs of FIT (20, 25, 30, 35 and …
Endoscopist characteristics that influence the quality of colonoscopy.
Jover R, Zapater P, Bujanda L, Hernández V, Cubiella J, Pellisé M, Ponce M, Ono A, Lanas A, Seoane A, Marín-Gabriel JC, Chaparro M, Cacho G, Herreros-de-Tejada A, Fernández-Díez S, Peris A, Nicolás-Pérez D, Murcia O, Castells A, Quintero E; COLONPREV Study Investigators. Jover R, et al. Endoscopy. 2016 Mar;48(3):241-7. doi: 10.1055/s-0042-100185. Epub 2016 Feb 4. Endoscopy. 2016. PMID: 26845473
Programmatic screening for colorectal cancer: the COLONPREV study.
Castells A, Quintero E. Castells A, et al. Dig Dis Sci. 2015 Mar;60(3):672-80. doi: 10.1007/s10620-014-3446-2. Epub 2014 Dec 10. Dig Dis Sci. 2015. PMID: 25492501 Clinical Trial.
The COLONPREV study is an ongoing multicenter, nationwide, randomized controlled trial aimed at evaluating the efficacy of once-only colonoscopy and biennial fecal immunochemical testing with respect to the reduction of CRC-related mortality at 10 years in average-risk col …
The COLONPREV study is an ongoing multicenter, nationwide, randomized controlled trial aimed at evaluating the efficacy of once-only …
Diagnostic accuracy of fecal immunochemical test in average- and familial-risk colorectal cancer screening.
Cubiella J, Castro I, Hernandez V, González-Mao C, Rivera C, Iglesias F, Alves MT, Cid L, Soto S, De-Castro L, Vega P, Hermo JA, Macenlle R, Martínez A, Estevez P, Cid E, Herreros-Villanueva M, Portillo I, Bujanda L, Fernández-Seara J; COLONPREV study investigators. Cubiella J, et al. United European Gastroenterol J. 2014 Dec;2(6):522-9. doi: 10.1177/2050640614553285. United European Gastroenterol J. 2014. PMID: 25452848 Free PMC article.
Diagnostic performance of fecal immunochemical test and sigmoidoscopy for advanced right-sided colorectal neoplasms.
Castro I, Estevez P, Cubiella J, Hernandez V, González-Mao C, Rivera C, Iglesias F, Cid L, Soto S, de-Castro L, Vega P, Hermo JA, Macenlle R, Martínez A, Cid E, Gil I, Larzabal M, Bujanda L, Castells A; COLONPREV study investigators. Castro I, et al. Dig Dis Sci. 2015 May;60(5):1424-32. doi: 10.1007/s10620-014-3434-6. Epub 2014 Nov 19. Dig Dis Sci. 2015. PMID: 25407805
Characteristics of adenomas detected by fecal immunochemical test in colorectal cancer screening.
Cubiella J, Castro I, Hernandez V, González-Mao C, Rivera C, Iglesias F, Cid L, Soto S, de-Castro L, Vega P, Hermo JA, Macenlle R, Martínez A, Martínez-Ares D, Estevez P, Cid E, Herreros-Villanueva M, Portillo I, Bujanda L, Fernández-Seara J; COLONPREV study investigators. Cubiella J, et al. Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1884-92. doi: 10.1158/1055-9965.EPI-13-1346. Epub 2014 Jun 24. Cancer Epidemiol Biomarkers Prev. 2014. PMID: 24962836
Participation and detection rates by age and sex for colonoscopy versus fecal immunochemical testing in colorectal cancer screening.
Salas D, Vanaclocha M, Ibáñez J, Molina-Barceló A, Hernández V, Cubiella J, Zubizarreta R, Andreu M, Hernández C, Pérez-Riquelme F, Cruzado J, Carballo F, Bujanda L, Sarasqueta C, Portillo I, de la Vega-Prieto M, Morillas JD, Valentín V, Lanas A, Quintero E, Castells A. Salas D, et al. Cancer Causes Control. 2014 Aug;25(8):985-97. doi: 10.1007/s10552-014-0398-y. Epub 2014 May 24. Cancer Causes Control. 2014. PMID: 24859111 Clinical Trial.
METHODS: This analysis was performed with data from the first screening round within the COLONPREV study, a population-based, multicenter, nationwide trial carried out in Spain. ...
METHODS: This analysis was performed with data from the first screening round within the COLONPREV study, a population-based, multice …
Rate of detection of advanced neoplasms in proximal colon by simulated sigmoidoscopy vs fecal immunochemical tests.
Castells A, Quintero E, Álvarez C, Bujanda L, Cubiella J, Salas D, Lanas A, Carballo F, Morillas JD, Hernández C, Jover R, Hijona E, Portillo I, Enríquez-Navascués JM, Hernández V, Martínez-Turnes A, Menéndez-Villalva C, González-Mao C, Sala T, Ponce M, Andrés M, Teruel G, Peris A, Sopeña F, González-Rubio F, Seoane-Urgorri A, Grau J, Serradesanferm A, Pozo À, Pellisé M, Balaguer F, Ono A, Cruzado J, Pérez-Riquelme F, Alonso-Abreu I, Carrillo-Palau M, de la Vega-Prieto M, Iglesias R, Amador J, Blanco JM, Sastre R, Ferrándiz J, González-Hernández MJ, Andreu M, Bessa X; COLONPREV Study Investigators. Castells A, et al. Clin Gastroenterol Hepatol. 2014 Oct;12(10):1708-16.e4. doi: 10.1016/j.cgh.2014.03.022. Epub 2014 Mar 27. Clin Gastroenterol Hepatol. 2014. PMID: 24681078 Clinical Trial.
Fecal immunochemical test accuracy in average-risk colorectal cancer screening.
Hernandez V, Cubiella J, Gonzalez-Mao MC, Iglesias F, Rivera C, Iglesias MB, Cid L, Castro I, de Castro L, Vega P, Hermo JA, Macenlle R, Martínez-Turnes A, Martínez-Ares D, Estevez P, Cid E, Vidal MC, López-Martínez A, Hijona E, Herreros-Villanueva M, Bujanda L, Rodriguez-Prada JI; COLONPREV Study Investigators. Hernandez V, et al. World J Gastroenterol. 2014 Jan 28;20(4):1038-47. doi: 10.3748/wjg.v20.i4.1038. World J Gastroenterol. 2014. PMID: 24574776 Free PMC article.
Effect of oral anticoagulants on the outcome of faecal immunochemical test.
Bujanda L, Sarasqueta C, Lanas Á, Quintero E, Cubiella J, Hernandez V, Morillas JD, Perez-Fernández T, Salas D, Andreu M, Carballo F, Bessa X, Portillo I, Jover R, Balaguer F, Cosme A, Castells A; COLONPREV study investigators. Bujanda L, et al. Br J Cancer. 2014 Mar 4;110(5):1334-7. doi: 10.1038/bjc.2014.38. Epub 2014 Feb 4. Br J Cancer. 2014. PMID: 24496455 Free PMC article. Clinical Trial.
Effect of aspirin and antiplatelet drugs on the outcome of the fecal immunochemical test.
Bujanda L, Lanas Á, Quintero E, Castells A, Sarasqueta C, Cubiella J, Hernandez V, Morillas JD, Perez-Fernández T, Salas D, Andreu M, Carballo F, Bessa X, Cosme A, Jover R; COLONPREV Study Investigators. Bujanda L, et al. Mayo Clin Proc. 2013 Jul;88(7):683-9. doi: 10.1016/j.mayocp.2013.04.016. Epub 2013 Jun 7. Mayo Clin Proc. 2013. PMID: 23751980 Clinical Trial.
Risk of advanced proximal neoplasms according to distal colorectal findings: comparison of sigmoidoscopy-based strategies.
Castells A, Bessa X, Quintero E, Bujanda L, Cubiella J, Salas D, Lanas A, Carballo F, Morillas JD, Hernández C, Jover R, Montalvo I, Arenas J, Cosme A, Hernández V, Iglesias B, Castro I, Cid L, Sala T, Ponce M, Andrés M, Teruel G, Peris A, Roncales MP, González-Rubio F, Seoane-Urgorri A, Grau J, Serradesanferm A, Pellisé M, Ono A, Cruzado J, Pérez-Riquelme F, Alonso-Abreu I, Carrillo-Palau M, de la Vega-Prieto M, Iglesias R, Amador J, Blanco JM, Sastre R, Ferrándiz J, González-Hernández MJ, Andreu M; COLONPREV study investigators. Castells A, et al. J Natl Cancer Inst. 2013 Jun 19;105(12):878-86. doi: 10.1093/jnci/djt117. Epub 2013 May 24. J Natl Cancer Inst. 2013. PMID: 23708054 Clinical Trial.
Relationship of colonoscopy-detected serrated polyps with synchronous advanced neoplasia in average-risk individuals.
Álvarez C, Andreu M, Castells A, Quintero E, Bujanda L, Cubiella J, Salas D, Lanas Á, Carballo F, Morillas JD, Hernández C, Jover R, Sarasqueta C, Enriquéz-Navascués JM, Hernández V, Estévez P, Macenlle R, Sala T, Balaguer F, Pellisé M, Moreira L, Gil I, Peris A, González-Rubio F, Ferrández A, Poves C, Ponce M, Grau J, Serradesanferm A, Ono A, Cruzado J, Pérez-Riquelme F, Alonso-Abreu I, Carrillo-Palau M, Santander C, Díaz Tasende J, Herreros A, Cacho G, Barranco LE, Bessa X; ColonPrev study investigators. Álvarez C, et al. Gastrointest Endosc. 2013 Aug;78(2):333-341.e1. doi: 10.1016/j.gie.2013.03.003. Epub 2013 Apr 25. Gastrointest Endosc. 2013. PMID: 23623039 Clinical Trial.
DESIGN: Multicenter, randomized, controlled trial. SETTING: The ColonPrev study, a population-based, multicenter, nationwide, randomized, controlled trial. ...
DESIGN: Multicenter, randomized, controlled trial. SETTING: The ColonPrev study, a population-based, multicenter, nationwide, randomi …
Modifiable endoscopic factors that influence the adenoma detection rate in colorectal cancer screening colonoscopies.
Jover R, Zapater P, Polanía E, Bujanda L, Lanas A, Hermo JA, Cubiella J, Ono A, González-Méndez Y, Peris A, Pellisé M, Seoane A, Herreros-de-Tejada A, Ponce M, Marín-Gabriel JC, Chaparro M, Cacho G, Fernández-Díez S, Arenas J, Sopeña F, de-Castro L, Vega-Villaamil P, Rodríguez-Soler M, Carballo F, Salas D, Morillas JD, Andreu M, Quintero E, Castells A; COLONPREV study investigators. Jover R, et al. Gastrointest Endosc. 2013 Mar;77(3):381-389.e1. doi: 10.1016/j.gie.2012.09.027. Epub 2012 Dec 4. Gastrointest Endosc. 2013. PMID: 23218945 Clinical Trial.
Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening.
Quintero E, Castells A, Bujanda L, Cubiella J, Salas D, Lanas Á, Andreu M, Carballo F, Morillas JD, Hernández C, Jover R, Montalvo I, Arenas J, Laredo E, Hernández V, Iglesias F, Cid E, Zubizarreta R, Sala T, Ponce M, Andrés M, Teruel G, Peris A, Roncales MP, Polo-Tomás M, Bessa X, Ferrer-Armengou O, Grau J, Serradesanferm A, Ono A, Cruzado J, Pérez-Riquelme F, Alonso-Abreu I, de la Vega-Prieto M, Reyes-Melian JM, Cacho G, Díaz-Tasende J, Herreros-de-Tejada A, Poves C, Santander C, González-Navarro A; COLONPREV Study Investigators. Quintero E, et al. N Engl J Med. 2012 Feb 23;366(8):697-706. doi: 10.1056/NEJMoa1108895. N Engl J Med. 2012. PMID: 22356323 Free article. Clinical Trial.