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The Effect of Pomegranate Tea on the Clinical Outcomes and Symptom Alleviation in COVID-19 Patients: A Double-Blind Randomized Clinical Trial.
Reisi-Vanani V, Rahmani F, Kheiri S, Soleimani A, Bijad E, Abolhansanzadeh Z, Jamshidi-Kia F, Lorigooini Z. Reisi-Vanani V, et al. Can J Infect Dis Med Microbiol. 2025 Dec 7;2025:3192659. doi: 10.1155/cjid/3192659. eCollection 2025. Can J Infect Dis Med Microbiol. 2025. PMID: 41473214 Free PMC article.
Recent studies suggest pomegranate (Punica granatum) may offer immunomodulatory and antiviral benefits attributed to its polyphenol content. This study aimed to evaluate the impact of pomegranate tea on the clinical characteristics of COVID-19 patients and investigate its …
Recent studies suggest pomegranate (Punica granatum) may offer immunomodulatory and antiviral benefits attributed to its polyphenol c …
Targeting SIRT1: A Potential Strategy for Combating Severe COVID-19.
Shokri-Afra H, Saber Jeyvan F, Barartabar Z, Khanicheragh P, Yousefi Abdolmaleki E, Ilbeigi D, Musavi H, Malekzadegan Y. Shokri-Afra H, et al. Biomed Res Int. 2025 Dec 17;2025:9507417. doi: 10.1155/bmri/9507417. eCollection 2025. Biomed Res Int. 2025. PMID: 41416347 Free PMC article. Review.
Moringa oleifera potential for the treatment and prevention of COVID-19 involving molecular interaction, antioxidant properties and kinetic mechanism.
Hamadou M, Bakwo Bassogog CB, Obadias FV, Assaly AD, Mune Mune MA. Hamadou M, et al. PLoS One. 2025 Dec 3;20(12):e0337904. doi: 10.1371/journal.pone.0337904. eCollection 2025. PLoS One. 2025. PMID: 41337461 Free PMC article.
Phytochemicals in Moringa oleifera leaves were extracted using aqueous and hydromethanolic solvent system. It was found that polyphenols (4.20-5.01 mg GAE/g DM) and flavonoids (95.86-135.41 mg QE/ g DM) were the major constituents in the extracts. ...
Phytochemicals in Moringa oleifera leaves were extracted using aqueous and hydromethanolic solvent system. It was found that polyphenols …
Emerging molecular targets and natural therapeutics for idiopathic pulmonary fibrosis: Insights into mechanisms, risks, and COVID-19 links.
Singh R, Pradhan AK, Roy D, Arya M, Chakravarti R, Dutta D, Kundu A, Bhaduri S, Singh P, Ahmed KT, Bhattacharya B. Singh R, et al. Respir Med. 2025 Dec;250:108519. doi: 10.1016/j.rmed.2025.108519. Epub 2025 Nov 14. Respir Med. 2025. PMID: 41242507 Review.
This review will also discuss the role of natural phytocompounds, including steroidal saponin, stilbenoid polyphenol resveratrol, safflomin of Carthamus tinctorius or safflower yellow, along with several genetic modulation approaches in addressing IPF. ...
This review will also discuss the role of natural phytocompounds, including steroidal saponin, stilbenoid polyphenol resveratrol, saf …
The Role of Traditional Chinese Medicine in COVID-19 Treatment: Integrating Ancient Wisdom with Modern Medicine.
Bjørklund G, Antonyak H, Lysiuk R, Dzhura N, Gurgas L, Hangan T. Bjørklund G, et al. Curr Med Chem. 2025 Jul 28. doi: 10.2174/0109298673378502250707131529. Online ahead of print. Curr Med Chem. 2025. PMID: 40735994
Key components such as glycyrrhizin, quercetin, and resveratrol, along with fungal, animal, and mineral preparations, contribute to the therapeutic efficacy of TCM. Some individual polyphenolics, found in TCM formulations, significantly contribute to anti-SARS-CoV-2 effect …
Key components such as glycyrrhizin, quercetin, and resveratrol, along with fungal, animal, and mineral preparations, contribute to the ther …
Post-COVID Condition and Neuroinflammation: Possible Management with Antioxidants.
Cárdenas-Rodríguez N, Ignacio-Mejía I, Mejía-Barradas CM, Ortega-Cuellar D, Muñoz-González F, Vargas-Hernández MA, Albores-Méndez EM, Ibáñez-Cervantes G, Medina-Santillán R, Hernández-Ortiz A, Herrera-López E, Bandala C. Cárdenas-Rodríguez N, et al. Antioxidants (Basel). 2025 Jul 8;14(7):840. doi: 10.3390/antiox14070840. Antioxidants (Basel). 2025. PMID: 40722944 Free PMC article. Review.
A wide range of compounds-including vitamins, polyphenols, and endogenous antioxidants-have shown promise in mitigating neuroinflammation and oxidative damage in both clinical and experimental settings. ...
A wide range of compounds-including vitamins, polyphenols, and endogenous antioxidants-have shown promise in mitigating neuroinflamma …
Consumption of polyphenols, lipid profile, and markers of lipid peroxidation in patients with COVID-19.
de Azevedo MAF, de Carvalho VBL, Monteiro NVDN, Primo MGS, Ribeiro Mendes V, de Farias LM, Moura MSB, Abreu LLC, Macedo JL, Viola PCAF, de Matos Neto EM, Dos Santos Mallet JR, Martins MDCCE. de Azevedo MAF, et al. Food Funct. 2025 Jul 14;16(14):5859-5870. doi: 10.1039/d5fo00571j. Food Funct. 2025. PMID: 40586759
While viral infections such as COVID-19 can adversely affect lipid profiles, dietary polyphenol intake may improve lipid parameters and mitigate complications. Objective: To investigate the relationship between polyphenol intake, lipid profile, and lipid peroxidatio …
While viral infections such as COVID-19 can adversely affect lipid profiles, dietary polyphenol intake may improve lipid parameters a …
[Experience of using grape polyphenol concentrate in elderly patients with bronchial asthma in the post-COVID period.].
Beloglazov VA, Yatskov IA, Kumelsky ED, Teslenko MA. Beloglazov VA, et al. Adv Gerontol. 2025;38(1):145-149. Adv Gerontol. 2025. PMID: 40570227 Russian.
Objective - to study the effect of adding polyphenolic grape concentrate to the course of spa treatment in patients with bronchial asthma and post-covid syndrome on the state of LGI, intestinal permeability and edotoxemia. ...The intervention group (n=40) received grape …
Objective - to study the effect of adding polyphenolic grape concentrate to the course of spa treatment in patients with bronchial as …
Immune-Boosting and Antiviral Effects of Antioxidants in COVID-19 Pneumonia: A Therapeutic Perspective.
Sanduzzi Zamparelli S, Sanduzzi Zamparelli A, Bocchino M. Sanduzzi Zamparelli S, et al. Life (Basel). 2025 Jan 16;15(1):113. doi: 10.3390/life15010113. Life (Basel). 2025. PMID: 39860053 Free PMC article. Review.
Studies exploring antioxidants, including vitamins, trace elements, nitric oxide (NO), ozone (O(3)), glutathione (GSH), L-carnitine, melatonin, bromelain, N-acetylcysteine (NAC), and numerous polyphenols, have yielded promising outcomes. Through their ROS-scavenging proper …
Studies exploring antioxidants, including vitamins, trace elements, nitric oxide (NO), ozone (O(3)), glutathione (GSH), L-carnitine, melaton …
Antioxidant Nutraceuticals: Their Adjunct Role in the Management of COVID-19 Infections and Post-COVID Syndrome.
Mojgani N, Dadar M, Shahali Y, Simal-Gandara J, Kumar P, Ashique S, Bhowmick M, Kumar H. Mojgani N, et al. Infect Disord Drug Targets. 2025;25(6):e18715265320091. doi: 10.2174/0118715265320091241017161919. Infect Disord Drug Targets. 2025. PMID: 39757610 Review.
In this review, we intend to present the recent understanding and converse scientific implications for the use of nutraceutical antioxidants such as vitamins, minerals, probiotics, and polyphenols like bee propolis, in the management of viral respiratory diseases and post- …
In this review, we intend to present the recent understanding and converse scientific implications for the use of nutraceutical antioxidants …
Herbal Medicine in Three Different Mediterranean Living Areas During the COVID-19 Pandemic: The Role of Polyphenolic-Rich Thyme-like Plants.
Khalil M, Abdallah H, Calasso M, Khalil N, Daher A, Missaoui J, Diab F, Zeaiter L, Vergani L, Di Ciaula A, Portincasa P. Khalil M, et al. Plants (Basel). 2024 Nov 28;13(23):3340. doi: 10.3390/plants13233340. Plants (Basel). 2024. PMID: 39683135 Free PMC article.
Notably, in Lebanon, Za'atar, a thyme-like plant, correlated with reduced symptoms, suggesting potential protective effects that are likely due to its polyphenol richness. This study underscores the persistent reliance on traditional medicinal plants remedies in the Medite …
Notably, in Lebanon, Za'atar, a thyme-like plant, correlated with reduced symptoms, suggesting potential protective effects that are likely …
Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment.
Papadopoulou P, Polissidis A, Kythreoti G, Sagnou M, Stefanatou A, Theoharides TC. Papadopoulou P, et al. Int J Mol Sci. 2024 Oct 14;25(20):11040. doi: 10.3390/ijms252011040. Int J Mol Sci. 2024. PMID: 39456822 Free PMC article. Review.
The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognitive impairment. ...The evidence reviewed strengthens the translational value of olive polyphenols in conditions involving cognitive d …
The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognit …
Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality-A systematic review and meta-analysis.
Santa K, Tamaki R, Watanabe K, Nagaoka I. Santa K, et al. Front Nutr. 2024 Oct 7;11:1465324. doi: 10.3389/fnut.2024.1465324. eCollection 2024. Front Nutr. 2024. PMID: 39434894 Free PMC article.
RESULTS: This study found that a healthy diet, particularly rich in phytochemicals such as polyphenols and flavonoids, is effective against COVID-19. An association was detected between blood vitamin D levels and COVID-19 mortality. ...
RESULTS: This study found that a healthy diet, particularly rich in phytochemicals such as polyphenols and flavonoids, is effective a …
Identifying Mechanism of Resveratrol for the Treatment of COVID-19 and Idiopathic Pulmonary Fibrosis via Suppressing Inflammation Response Through IL-17 Signaling Pathway from the Perspectives of in silico Study.
Wang J, Shi J, Jia N, Sun Q. Wang J, et al. Curr Med Chem. 2025;32(42):9775-9792. doi: 10.2174/0109298673308841240930044555. Curr Med Chem. 2025. PMID: 39400013
BACKGROUND: Both coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) could cause severe pulmonary injury and have extremely dismal prognoses with a high risk of mortality. Resveratrol (RSV), a natural polyphenol, has promising potential in the treat …
BACKGROUND: Both coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) could cause severe pulmonary injury and have ex …
The Potential of Natural Products in the Management of COVID-19.
Saber MM, Salama MM, Badary OA. Saber MM, et al. Adv Exp Med Biol. 2024;1457:215-235. doi: 10.1007/978-3-031-61939-7_12. Adv Exp Med Biol. 2024. PMID: 39283429 Review.
In this chapter, we highlight on the potential of alkaloids, phenolic and polyphenolic compounds, flavonoids, terpenoids, cardiac glycosides, and natural products from marine sources against the human coronavirus via different mode of actions. ...
In this chapter, we highlight on the potential of alkaloids, phenolic and polyphenolic compounds, flavonoids, terpenoids, cardiac gly …
How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents.
Liu ZQ. Liu ZQ. Eur J Med Chem. 2024 Nov 15;278:116788. doi: 10.1016/j.ejmech.2024.116788. Epub 2024 Sep 4. Eur J Med Chem. 2024. PMID: 39236494 Review.
Notably, typical natural products presented herein consist of polyphenols, lignans, alkaloids, terpenoids, and peptides, which exert an advantage for the further discovery of novel anti-COVID-19 drugs from plant herbs. ...
Notably, typical natural products presented herein consist of polyphenols, lignans, alkaloids, terpenoids, and peptides, which exert …
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, Giorgino G, Chiaramonte C, D'Agostini C, Bernardini S, Pieri M. Noce A, et al. Pharmaceuticals (Basel). 2024 Apr 5;17(4):463. doi: 10.3390/ph17040463. Pharmaceuticals (Basel). 2024. PMID: 38675423 Free PMC article.
The OFS's vitamin C content was equal to 22.17 mg/g (8.87 mg/capsule). The OFS's total polyphenol content was 43.98 mg/g gallic acid equivalents. At the end of the in vivo study, we highlighted a significant decrease in the inflammatory parameters in the OFS period, compar …
The OFS's vitamin C content was equal to 22.17 mg/g (8.87 mg/capsule). The OFS's total polyphenol content was 43.98 mg/g gallic acid …
Moringa oleifera and Its Biochemical Compounds: Potential Multi-targeted Therapeutic Agents Against COVID-19 and Associated Cancer Progression.
Yousefi Rad A, Rastegari AA, Shahanipour K, Monajemi R. Yousefi Rad A, et al. Biochem Genet. 2025 Apr;63(2):936-959. doi: 10.1007/s10528-024-10758-w. Epub 2024 Apr 7. Biochem Genet. 2025. PMID: 38583096 Review.
The article discusses the ability of M. oleifera to modulate NF-kappaB, MAPK, mTOR, NLRP3 inflammasome, and other inflammatory pathways, as well as the polyphenols and flavonoids like quercetin and kaempferol, that contribute to its anti-inflammatory properties. ...
The article discusses the ability of M. oleifera to modulate NF-kappaB, MAPK, mTOR, NLRP3 inflammasome, and other inflammatory pathways, as …
Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal.
Samarelli F, Graziano G, Gambacorta N, Graps EA, Leonetti F, Nicolotti O, Altomare CD. Samarelli F, et al. Viruses. 2024 Mar 14;16(3):450. doi: 10.3390/v16030450. Viruses. 2024. PMID: 38543815 Free PMC article.
An overview of the main features and therapeutic potentials of small molecules is provided for the thromboxane receptor antagonist ramatroban, the pan-caspase inhibitor emricasan, and the sodium-hydrogen antiporter 1 (NHE-1) inhibitor rimeporide, as well as natural polyphenoli …
An overview of the main features and therapeutic potentials of small molecules is provided for the thromboxane receptor antagonist ramatroba …
Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy.
Vajdi M, Karimi A, Hassanizadeh S, Farhangi MA, Bagherniya M, Askari G, Roufogalis BD, Davies NM, Sahebkar A. Vajdi M, et al. Pharmacol Rep. 2024 Apr;76(2):307-327. doi: 10.1007/s43440-024-00585-6. Epub 2024 Mar 18. Pharmacol Rep. 2024. PMID: 38498260 Review.
Researchers have developed methods for separating and isolating polyphenols from complex matrices. Polyphenols are effective in treating common viral infections, including COVID-19, and can also boost immunity. Polyphenolic-based antiviral medications can mit …
Researchers have developed methods for separating and isolating polyphenols from complex matrices. Polyphenols are effective i …
Thai traditional medicines reduce CD147 levels in lung cells: Potential therapeutic candidates for cancers, inflammations, and COVID-19.
Sukadeetad K, Sripanidkulchai B, Tangsukworakhun S, Payomchuen R, Sakulchatrungroj A, Supmoon S, Punkvang A. Sukadeetad K, et al. J Ethnopharmacol. 2024 Jun 12;327:118042. doi: 10.1016/j.jep.2024.118042. Epub 2024 Mar 15. J Ethnopharmacol. 2024. PMID: 38493907
RESULTS: UM extracts showed the most efficiency for reduction of CD147 levels in the cytoplasm and perinuclear of BEAS-2B cells stimulated with CypA. Phenolic compounds composing polyphenols, polyphenol sugars, and flavonoids were identified as the major chemical co …
RESULTS: UM extracts showed the most efficiency for reduction of CD147 levels in the cytoplasm and perinuclear of BEAS-2B cells stimulated w …
Immunoregulatory effects of nanocurcumin in inflammatory milieu: Focus on COVID-19.
Arab FL, Hoseinzadeh A, Mohammadi FS, Rajabian A, Faridzadeh A, Mahmoudi M. Arab FL, et al. Biomed Pharmacother. 2024 Feb;171:116131. doi: 10.1016/j.biopha.2024.116131. Epub 2024 Jan 9. Biomed Pharmacother. 2024. PMID: 38198954 Free article. Review.
Numerous clinical trials have consistently shown that curcumin, a polyphenolic compound, is safe and well-tolerated even at high doses. There is no toxicity limit. ...
Numerous clinical trials have consistently shown that curcumin, a polyphenolic compound, is safe and well-tolerated even at high dose …
The potential preventive role of a dietary supplement containing hydroxytyrosol in COVID-19: a multi-center study.
Dhuli K, Micheletti C, Medori MC, Madeo G, Bonetti G, Donato K, Gaffuri F, Tartaglia GM, Michelini S, Fiorentino A, Cesarz D, Connelly ST, Capodicasa N, Bertelli M. Dhuli K, et al. Eur Rev Med Pharmacol Sci. 2023 Dec;27(6 Suppl):33-38. doi: 10.26355/eurrev_202312_34687. Eur Rev Med Pharmacol Sci. 2023. Retraction in: Eur Rev Med Pharmacol Sci. 2024 Apr;28(8):3288. doi: 10.26355/eurrev_202404_36067. PMID: 38112946 Free article. Retracted. Clinical Trial.
Various therapies have been proposed for treating COVID-19, among which antiviral drugs and monoclonal antibodies, but natural molecules have gained attention for their potential antiviral properties against various viral infections, including COVID-19. The use of hydroxytyrosol …
Various therapies have been proposed for treating COVID-19, among which antiviral drugs and monoclonal antibodies, but natural molecules hav …
The Role of Olive Tree Polyphenols In The Prevention of COVID-19: A Scoping Review Part 2.
Dhuli K, Micheletti C, Maltese PE, Tanzi B, Benedetti S, Tezzele S, Mareso C, Connelly ST, Gaffuri F, Tartaglia GM, Nodari S, Arabia G, Fioretti F, Calandri C, Perrone MA, Bertelli M. Dhuli K, et al. Clin Ter. 2023 Nov-Dec;174(Suppl 2(6)):149-153. doi: 10.7417/CT.2023.2481. Clin Ter. 2023. PMID: 37994758 Free article.
Polyphenols have renown anti-inflammatory and multitarget antiviral effects on several virus families, which could be among the reasons of the beneficial effects of the Mediterranean diet against COVID-19. This scoping review is focused on the effect of olive tree polyp …
Polyphenols have renown anti-inflammatory and multitarget antiviral effects on several virus families, which could be among the reaso …
The Role of Olive Tree Polyphenols in the Prevention of COVID-19: A Scoping Review, part 1.
Bonetti G, Donato K, Medori MC, Cecchin S, Marceddu G, Gadler M, Guerri G, Cristofoli F, Connelly ST, Gaffuri F, Tartaglia GM, Nodari S, Arabia G, Fioretti F, Gregorace E, Perrone MA, Bertelli M. Bonetti G, et al. Clin Ter. 2023 Nov-Dec;174(Suppl 2(6)):142-148. doi: 10.7417/CT.2023.2480. Clin Ter. 2023. PMID: 37994757 Free article.
After reviewing previous studies, olive leaves, being rich in polyphenolic compounds (a large class of bioactive substances naturally found in plants), were proposed as a viable co-therapy supplement to treat and improve clinical symptoms in COVID-19 patients. ...The aim o …
After reviewing previous studies, olive leaves, being rich in polyphenolic compounds (a large class of bioactive substances naturally …
Buccopharyngeal route administered high polyphenolic olive oil and COVID-19: A pilot clinical trial.
Rodríguez-Argente F, Alba-Domínguez M, Díaz-Martínez MP, Díaz-Vergara C, Díaz-Márques B, Ferrero-Ortega P, Gil-Adrados AC, Gómez-Bernardo L, Gordo-Murillo L, Fuente EH, Jurado-Palomo J, Ortega-González Á, Machado-Gallas J, Moreno-Ancillo Á, Ávila-Martín G, Marín-Guerrero AC, Álvarez-Gregori J. Rodríguez-Argente F, et al. Immun Inflamm Dis. 2023 Oct;11(10):e1054. doi: 10.1002/iid3.1054. Immun Inflamm Dis. 2023. PMID: 37904687 Free PMC article. Clinical Trial.
The investigators sought to determine whether participants following immunomodulation with tiny quantities of high polyphenolic olive oil administered through an oromucosal route could have a better outcome in COVID-19. ...This finding strongly support the appropriateness …
The investigators sought to determine whether participants following immunomodulation with tiny quantities of high polyphenolic olive …
Anti-Viral Activity of Bioactive Molecules of Silymarin against COVID-19 via In Silico Studies.
Zhang C, Sui Y, Liu S, Yang M. Zhang C, et al. Pharmaceuticals (Basel). 2023 Oct 17;16(10):1479. doi: 10.3390/ph16101479. Pharmaceuticals (Basel). 2023. PMID: 37895950 Free PMC article.
Silymarin, a mixture of herb-derived polyphenolic flavonoids extracted from the milk thistle, possesses potent antioxidative, anti-apoptotic, and anti-inflammatory properties. ...
Silymarin, a mixture of herb-derived polyphenolic flavonoids extracted from the milk thistle, possesses potent antioxidative, anti-ap …
Exploration of Molecular Targets and Mechanisms of Curcumin in the Treatment of COVID-19 with Depression by an Integrative Pharmacology Strategy.
Zhu D, Zhou X. Zhu D, et al. Curr Pharm Des. 2023;29(31):2501-2519. doi: 10.2174/0113816128260436231016061938. Curr Pharm Des. 2023. PMID: 37881069
With the global pandemic of SARS-CoV-2, the incidence of COVID-19 comorbid with depression has increased significantly. Curcumin, a natural polyphenol compound, has been shown to have antidepressant and anti-coronavirus activities. ...
With the global pandemic of SARS-CoV-2, the incidence of COVID-19 comorbid with depression has increased significantly. Curcumin, a natural …
Therapeutic Potential of Bioactive Compounds from Edible Mushrooms to Attenuate SARS-CoV-2 Infection and Some Complications of Coronavirus Disease (COVID-19).
Baruah P, Patra A, Barge S, Khan MR, Mukherjee AK. Baruah P, et al. J Fungi (Basel). 2023 Aug 31;9(9):897. doi: 10.3390/jof9090897. J Fungi (Basel). 2023. PMID: 37755005 Free PMC article. Review.
The plentiful bioactive macromolecules in edible mushrooms, like polysaccharides, proteins, and other secondary metabolites (such as flavonoids, polyphenols, etc.), have been used to treat multiple diseases, including viral infections, by traditional healers and the medica …
The plentiful bioactive macromolecules in edible mushrooms, like polysaccharides, proteins, and other secondary metabolites (such as flavono …
Association of dietary intake of polyphenols, lignans, and phytosterols with immune-stimulating microbiota and COVID-19 risk in a group of Polish men and women.
Micek A, Bolesławska I, Jagielski P, Konopka K, Waśkiewicz A, Witkowska AM, Przysławski J, Godos J. Micek A, et al. Front Nutr. 2023 Aug 3;10:1241016. doi: 10.3389/fnut.2023.1241016. eCollection 2023. Front Nutr. 2023. PMID: 37599696 Free PMC article.
RESULTS: For all investigated polyphenols and phytosterols, except campesterol, every unit increase in the tertile of intake category was associated with a decrease in the odds of contracting COVID-19. ...CONCLUSION: The beneficial effects of polyphenols and phytost …
RESULTS: For all investigated polyphenols and phytosterols, except campesterol, every unit increase in the tertile of intake category …
Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial.
Ahmadi S, Mehrabi Z, Zare M, Ghadir S, Masoumi SJ. Ahmadi S, et al. Int J Clin Pract. 2023 Jul 28;2023:5734675. doi: 10.1155/2023/5734675. eCollection 2023. Int J Clin Pract. 2023. PMID: 37547100 Free PMC article. Clinical Trial.
BACKGROUND: Curcumin is a polyphenol derivative of the Curcuma longa rhizome, with potential antioxidant, anticancer, antidepressant, antiviral, and anti-inflammatory effects. ...
BACKGROUND: Curcumin is a polyphenol derivative of the Curcuma longa rhizome, with potential antioxidant, anticancer, antidepressant, …
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases.
Kakavandi S, Zare I, VaezJalali M, Dadashi M, Azarian M, Akbari A, Ramezani Farani M, Zalpoor H, Hajikhani B. Kakavandi S, et al. Cell Commun Signal. 2023 May 15;21(1):110. doi: 10.1186/s12964-023-01104-5. Cell Commun Signal. 2023. PMID: 37189112 Free PMC article. Review.
In addition, SARS-CoV-2 can stimulate pathological intracellular signaling pathways by triggering transcription factor hypoxia-inducible factor-1 (HIF-1), neuropilin-1 (NRP-1), CD147, and Eph receptors, which play important roles in the progression of neurodegenerative diseases l …
In addition, SARS-CoV-2 can stimulate pathological intracellular signaling pathways by triggering transcription factor hypoxia-inducible fac …
Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L.
Alexova R, Alexandrova S, Dragomanova S, Kalfin R, Solak A, Mehan S, Petralia MC, Fagone P, Mangano K, Nicoletti F, Tancheva L. Alexova R, et al. Molecules. 2023 Apr 27;28(9):3772. doi: 10.3390/molecules28093772. Molecules. 2023. PMID: 37175181 Free PMC article. Review.
Pomegranate (Punica granatum L.) is a rich source of polyphenols, including ellagitannins and ellagic acid. The plant is used in traditional medicine, and its purified components can provide anti-inflammatory and antioxidant activity and support of host defenses during vir …
Pomegranate (Punica granatum L.) is a rich source of polyphenols, including ellagitannins and ellagic acid. The plant is used in trad …
The Problem of Home Therapy during COVID-19 Pandemic in Italy: Government Guidelines versus Freedom of Cure?
Fazio S, Cosentino M, Marino F, Pandolfi S, Zanolin E, Bellavite P. Fazio S, et al. J Pharm Pharmacol Res. 2022 Aug 2;6(3):100-114. doi: 10.26502/fjppr.055. J Pharm Pharmacol Res. 2022. PMID: 37168835 Free PMC article.
To try to remedy this situation, several volunteer groups were formed, managing to promptlycure thousands of patients at home with non-steroidal anti-inflammatory drugs and a variety of re-purposed drugs (principally hydroxychloroquine, ivermectin) and supplements (such as antiox …
To try to remedy this situation, several volunteer groups were formed, managing to promptlycure thousands of patients at home with non-stero …
Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells.
Lin CK, Chen BY, Ting JU, Rogio KGG, Tsai PW, Liu YC. Lin CK, et al. J Taiwan Inst Chem Eng. 2023 Apr;145:104838. doi: 10.1016/j.jtice.2023.104838. Epub 2023 Apr 3. J Taiwan Inst Chem Eng. 2023. PMID: 37051508 Free PMC article.
METHODS: H. cordata leaves extracts by water and 60% ethanol solvent were analyzed for total polyphenols, antioxidant activity, cyclic voltammetry (CV), and MFCs. The bioactive compounds of H. cordata leaves extracts were assayed via LC/MS analysis. ...SIGNIFICANT FINDINGS …
METHODS: H. cordata leaves extracts by water and 60% ethanol solvent were analyzed for total polyphenols, antioxidant activity, cycli …
Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19.
England C, TrejoMartinez J, PerezSanchez P, Karki U, Xu J. England C, et al. Life (Basel). 2023 Feb 23;13(3):617. doi: 10.3390/life13030617. Life (Basel). 2023. PMID: 36983772 Free PMC article. Review.
Plants naturally produce a diverse range of bioactive compounds as secondary metabolites, such as alkaloids, terpenoids/terpenes and polyphenols, which are a rich source of countless antiviral compounds. Plants can also be genetically engineered to produce valuable recombi …
Plants naturally produce a diverse range of bioactive compounds as secondary metabolites, such as alkaloids, terpenoids/terpenes and poly …
The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19-Results from a pragmatic randomized clinical trial.
Ujjan ID, Khan S, Nigar R, Ahmed H, Ahmad S, Khan A. Ujjan ID, et al. Front Nutr. 2023 Jan 18;9:1023997. doi: 10.3389/fnut.2022.1023997. eCollection 2022. Front Nutr. 2023. PMID: 36742008 Free PMC article.
BACKGROUND: Curcumin (CUR) and quercetin (QUE), two natural polyphenols, possess diverse biological activities including broad-spectrum antiviral, antioxidant, and immunomodulatory effects. ...
BACKGROUND: Curcumin (CUR) and quercetin (QUE), two natural polyphenols, possess diverse biological activities including broad-spectr …
Quercetin as a possible complementary agent for early-stage COVID-19: Concluding results of a randomized clinical trial.
Di Pierro F, Khan A, Iqtadar S, Mumtaz SU, Chaudhry MNA, Bertuccioli A, Derosa G, Maffioli P, Togni S, Riva A, Allegrini P, Recchia M, Zerbinati N. Di Pierro F, et al. Front Pharmacol. 2023 Jan 13;13:1096853. doi: 10.3389/fphar.2022.1096853. eCollection 2022. Front Pharmacol. 2023. PMID: 36712674 Free PMC article.
Background: Quercetin, a natural polyphenol with demonstrated broad-spectrum antiviral, anti-inflammatory, and antioxidant properties, has been proposed as an adjuvant for early-stage coronavirus disease 2019 (COVID-19) infection. ...
Background: Quercetin, a natural polyphenol with demonstrated broad-spectrum antiviral, anti-inflammatory, and antioxidant properties …
Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway: A potential anti-inflammatory compound against inflammation-induced long-COVID.
Dissook S, Umsumarng S, Mapoung S, Semmarath W, Arjsri P, Srisawad K, Dejkriengkraikul P. Dissook S, et al. Front Med (Lausanne). 2023 Jan 9;9:1072056. doi: 10.3389/fmed.2022.1072056. eCollection 2022. Front Med (Lausanne). 2023. PMID: 36698809 Free PMC article.
The seed meal of Perilla frutescens (P. frutescens), which contains two major dietary polyphenols (rosmarinic acid and luteolin), has been reported to exhibit anti-inflammation activities. ...RESULTS: PFEA was found to contain Ra (388.70 11.12 mg/g extract) and Lu (248.82 …
The seed meal of Perilla frutescens (P. frutescens), which contains two major dietary polyphenols (rosmarinic acid and luteolin), has …
A review on biochemical constituents of pumpkin and their role as pharma foods; a key strategy to improve health in post COVID 19 period.
Hussain A, Kausar T, Sehar S, Sarwar A, Quddoos MY, Aslam J, Liaqat A, Siddique T, An QU, Kauser S, Rehman A, Nisar R. Hussain A, et al. Food Prod Process Nutr. 2023;5(1):22. doi: 10.1186/s43014-023-00138-z. Epub 2023 Mar 22. Food Prod Process Nutr. 2023. PMID: 40476921 Free PMC article. Review.
Pumpkins are well equipped with nutraceuticals and functional bioactives like tocopherols, polyphenols, terpenoids and lutein therefore, consumption and processing of this remarkable vegetable could be encouraged as pharma food due to its antihyperlipidemic, antiviral, ant …
Pumpkins are well equipped with nutraceuticals and functional bioactives like tocopherols, polyphenols, terpenoids and lutein therefo …
Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline.
Melrose J, Smith MM. Melrose J, et al. Front Biosci (Elite Ed). 2022 Oct 9;14(4):27. doi: 10.31083/j.fbe1404027. Front Biosci (Elite Ed). 2022. PMID: 36575843 Free article. Review.
The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue protective properties. Phytochemicals are widely distributed in plants, herbs and shrubs …
The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of widely-distributed polyphenolic p …
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