Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 2
2014 3
2015 1
2016 3
2017 3
2018 5
2019 7
2020 7
2021 12
2022 11
2023 10
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

60 results

Results by year

Filters applied: . Clear all
Page 1
Inhibition of pyruvate dehydrogenase accelerates anaerobic glycolysis under postmortem simulating conditions.
Taylor MJ, Stafford CD, Buhler JF, Dang DS, Alruzzi MA, Najm TA, Gerrard SD, Thornton KJ, van Vliet S, El-Kadi SW, Gerrard DE, Matarneh SK. Taylor MJ, et al. Meat Sci. 2024 Apr 7;213:109510. doi: 10.1016/j.meatsci.2024.109510. Online ahead of print. Meat Sci. 2024. PMID: 38598967
Four treatments were tested: 400 muM CPI-613, 1.5 U/ml Avidin, 400 muM CPI-613 + 1.5 U/ml Avidin, or control. ...The CPI-613 treatment did not elicit an alteration in the activity of these three enzymes. ...
Four treatments were tested: 400 muM CPI-613, 1.5 U/ml Avidin, 400 muM CPI-613 + 1.5 U/ml Avidin, or control. .. …
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma.
Nguyen TT, Torrini C, Shang E, Shu C, Mun JY, Gao Q, Humala N, Akman HO, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Nguyen TT, et al. JCI Insight. 2024 Mar 14;9(8):e172565. doi: 10.1172/jci.insight.172565. JCI Insight. 2024. PMID: 38483541 Free article.
CPI-613-mediated energy deprivation drove an integrated stress response with an upregulation of the BH3-only domain protein, Noxa, in an ATF4-dependent manner, as demonstrated by genetic loss-of-function experiments. Consistently, silencing of Noxa attenuated cell d …
CPI-613-mediated energy deprivation drove an integrated stress response with an upregulation of the BH3-only domain protein, N …
Inducing Melanoma Cell Apoptosis by ERp57/PDIA3 Antibody in the Presence of CPI-613 and Hydroxychloroquine.
Ichiki N, Saigo C, Hanamatsu Y, Iwata H, Takeuchi T. Ichiki N, et al. J Cancer. 2024 Feb 4;15(7):1779-1785. doi: 10.7150/jca.92252. eCollection 2024. J Cancer. 2024. PMID: 38434963 Free PMC article.
Therefore, we intended to examine the effects of a combination of CPI-613 and hydroxychloroquine on the growth of melanoma cells in the present study. ...The combination of CPI-613 and hydroxychloroquine enhanced the localization of ERp57/PDIA3 to the …
Therefore, we intended to examine the effects of a combination of CPI-613 and hydroxychloroquine on the growth of melanoma cel …
Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked.
Xu R, Yuan LS, Gan YQ, Lu N, Li YP, Zhou ZY, Zha QB, He XH, Wong TS, Ouyang DY. Xu R, et al. Free Radic Biol Med. 2024 Feb 20;212:117-132. doi: 10.1016/j.freeradbiomed.2023.12.029. Epub 2023 Dec 25. Free Radic Biol Med. 2024. PMID: 38151213
Here we established cellular models by pharmacological blockade of energy metabolism, followed by stimulation with a K(+) efflux inducer (ATP or nigericin). Two energy metabolic inhibitors, namely CPI-613 that targets alpha-ketoglutarate dehydrogenase and pyruvate d …
Here we established cellular models by pharmacological blockade of energy metabolism, followed by stimulation with a K(+) efflux inducer (AT …
Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway.
Gao X, Li H, Wang S, Long X, Guo X, Hua H, Li D. Gao X, et al. Bioorg Med Chem Lett. 2024 Jan 1;97:129545. doi: 10.1016/j.bmcl.2023.129545. Epub 2023 Nov 7. Bioorg Med Chem Lett. 2024. PMID: 37939862
For the therapeutic treatment of rheumatism, acute arthritis, and rheumatoid arthritis based on Qingfengteng, sinomenine hydrochloride was recently made the principal active ingredient in various dosage forms. 8-Bis(benzylthio)octanoic acid (CPI-613) was an orphan m …
For the therapeutic treatment of rheumatism, acute arthritis, and rheumatoid arthritis based on Qingfengteng, sinomenine hydrochloride was r …
Comparison of survival for metastatic pancreatic cancer patients treated with CPI-613 versus resected borderline-resectable pancreatic cancer patients.
Mangieri CW, Valenzuela CD, Solsky IB, Erali RA, Pardee T, Lima CMSR, Howerton R, Clark CJ, Shen P. Mangieri CW, et al. J Surg Oncol. 2023 Oct;128(5):844-850. doi: 10.1002/jso.27365. Epub 2023 Jun 21. J Surg Oncol. 2023. PMID: 37341164 Clinical Trial.
Survival was measured by overall survival (OS) for all study cases and disease-free survival (DFS) for resected cases with progression-free survival for CPI-613 cases. RESULTS: There were 20 patients in the CPI-613 cohort and 60 patients in the surgica …
Survival was measured by overall survival (OS) for all study cases and disease-free survival (DFS) for resected cases with progression-free …
Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04).
Mohan A, Griffith KA, Wuchu F, Zhen DB, Kumar-Sinha C, Crysler O, Hsiehchen D, Enzler T, Dippman D, Gunchick V, Achreja A, Animasahun O, Choppara S, Nenwani M, Chinnaiyan AM, Nagrath D, Zalupski MM, Sahai V. Mohan A, et al. Clin Cancer Res. 2023 Jul 5;29(13):2394-2400. doi: 10.1158/1078-0432.CCR-23-0036. Clin Cancer Res. 2023. PMID: 37115501 Free PMC article. Clinical Trial.
PURPOSE: Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. ...PATIENTS AND METHODS: Cell viability assays of devimistat gemcitabine and cisplatin (GC) were performed and the effect of devimistat on mitochondrial resp …
PURPOSE: Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. ...PATIENTS AND METHODS: Cell v …
Immunostimulation with chemotherapy of a ruthenium-arene complex via blockading CD47 signal in chronic myelogenous leukemia cells.
Hu G, Lv M, Guo B, Huang Y, Su Z, Qian Y, Xue X, Liu HK. Hu G, et al. J Inorg Biochem. 2023 Jun;243:112195. doi: 10.1016/j.jinorgbio.2023.112195. Epub 2023 Mar 22. J Inorg Biochem. 2023. PMID: 36996696
Increasing evidence suggests that blocking the "don't eat me" signal transmitted by the CD47 can promote the phagocytic ability of macrophages to cancer cells, which might be promising for improved cancer chemoimmunotherapy. In this work, we conjugated CPI-alkyne modified by D …
Increasing evidence suggests that blocking the "don't eat me" signal transmitted by the CD47 can promote the phagocytic ability of macrophag …
60 results