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Year Number of Results
1993 2
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2,404 results

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Page 1
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis.
Huang YH, Cai K, Xu PP, Wang L, Huang CX, Fang Y, Cheng S, Sun XJ, Liu F, Huang JY, Ji MM, Zhao WL. Huang YH, et al. Signal Transduct Target Ther. 2021 Jan 11;6(1):10. doi: 10.1038/s41392-020-00437-8. Signal Transduct Target Ther. 2021. PMID: 33431788 Free PMC article.
Among all 619 DLBCL patients, somatic mutations in KMT2D (19.5%) were most frequently observed, followed by mutations in ARID1A (8.7%), CREBBP (8.4%), KMT2C (8.2%), TET2 (7.8%), EP300 (6.8%), and EZH2 (2.9%). Among them, CREBBP/EP300 mutations were significantly ass …
Among all 619 DLBCL patients, somatic mutations in KMT2D (19.5%) were most frequently observed, followed by mutations in ARID1A (8.7%), C …
The Role of CREBBP/EP300 and Its Therapeutic Implications in Hematological Malignancies.
Zhu Y, Wang Z, Li Y, Peng H, Liu J, Zhang J, Xiao X. Zhu Y, et al. Cancers (Basel). 2023 Feb 14;15(4):1219. doi: 10.3390/cancers15041219. Cancers (Basel). 2023. PMID: 36831561 Free PMC article. Review.
CREBBP/EP300 dysregulation and CREBBP/EP300-containing complexes are critical for the initiation, progression, and chemoresistance of hematological malignancies. ...In this review, we summarize the role of CREBBP/EP300 in normal hematopoiesis and highlight th …
CREBBP/EP300 dysregulation and CREBBP/EP300-containing complexes are critical for the initiation, progression, and chemoresist …
Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.
Yi F, Cai C, Ruan B, Hao M, Yeo SK, Haas M, Yang F, Zhang X, Guan JL. Yi F, et al. Autophagy. 2023 Jun;19(6):1662-1677. doi: 10.1080/15548627.2022.2148432. Epub 2022 Nov 27. Autophagy. 2023. PMID: 36394358 Free PMC article.
Here, we report acetylation of several lysine residues of RB1CC1 by acetyltransferase CREBBP (CREB binding protein), with K276 as the major CREBBP acetylation site. K276 is also identified as a ubiquitination site by mass spectrometry, and acetylation at this site r …
Here, we report acetylation of several lysine residues of RB1CC1 by acetyltransferase CREBBP (CREB binding protein), with K276 as the …
CREBBP and p300 lysine acetyl transferases in the DNA damage response.
Dutto I, Scalera C, Prosperi E. Dutto I, et al. Cell Mol Life Sci. 2018 Apr;75(8):1325-1338. doi: 10.1007/s00018-017-2717-4. Epub 2017 Nov 23. Cell Mol Life Sci. 2018. PMID: 29170789 Free PMC article. Review.
The CREB-binding protein (CREBBP, or in short CBP) and p300 are lysine (K) acetyl transferases (KAT) belonging to the KAT3 family of proteins known to modify histones, as well as non-histone proteins, thereby regulating chromatin accessibility and transcription. ...
The CREB-binding protein (CREBBP, or in short CBP) and p300 are lysine (K) acetyl transferases (KAT) belonging to the KAT3 family of …
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Li J, Chin CR, Ying HY, Meydan C, Teater MR, Xia M, Farinha P, Takata K, Chu CS, Jiang Y, Eagles J, Passerini V, Tang Z, Rivas MA, Weigert O, Pugh TJ, Chadburn A, Steidl C, Scott DW, Roeder RG, Mason CE, Zappasodi R, Béguelin W, Melnick AM. Li J, et al. Nat Commun. 2024 Apr 3;15(1):2879. doi: 10.1038/s41467-024-47012-1. Nat Commun. 2024. PMID: 38570506 Free PMC article.
Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and …
Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B …
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors.
Crawford MC, Tripu DR, Barritt SA, Jing Y, Gallimore D, Kales SC, Bhanu NV, Xiong Y, Fang Y, Butler KAT, LeClair CA, Coussens NP, Simeonov A, Garcia BA, Dibble CC, Meier JL. Crawford MC, et al. ACS Chem Biol. 2023 Oct 20;18(10):2249-2258. doi: 10.1021/acschembio.3c00293. Epub 2023 Sep 22. ACS Chem Biol. 2023. PMID: 37737090 Free PMC article.
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicated in various cancers. ...Overall, our study demonstrates how knowledge of the relative inhibitor potency can guide the study of EP300/CRE …
The human acetyltransferase paralogues EP300 and CREBBP are master regulators of lysine acetylation whose activity has been implicate …
RNF6 promotes gastric cancer progression by regulating CCNA1/CREBBP transcription.
Jiang Q, Miao J, Wu F, Li F, Zhang J, Jing X, Cai S, Ma X, Wang X, Zhao L, Huang C. Jiang Q, et al. Cell Cycle. 2023 Sep;22(18):2018-2037. doi: 10.1080/15384101.2023.2275899. Epub 2023 Nov 23. Cell Cycle. 2023. PMID: 37904524 Free PMC article.
Cyclin A1 (CCNA1) and CREB binding protein (CREBBP) are downstream targets for RNF6 transcription regulation in GC. RNF6 binds to the promoter region of CCNA1/CREBBP and is actively regulating their expression in GC cells. ...Our study suggests that RNF6 promotes th …
Cyclin A1 (CCNA1) and CREB binding protein (CREBBP) are downstream targets for RNF6 transcription regulation in GC. RNF6 binds to the …
Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.
Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D. Jia D, et al. Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4. Cancer Discov. 2018. PMID: 30181244 Free PMC article.
In addition, a subset of Rb1/Trp53/Crebbp-deficient SCLC exhibited exceptional responses to Pracinostat in vivo Thus, CREBBP acts as a potent tumor suppressor in SCLC, and inactivation of CREBBP enhances responses to a targeted therapy.Significance: Our findi …
In addition, a subset of Rb1/Trp53/Crebbp-deficient SCLC exhibited exceptional responses to Pracinostat in vivo Thus, CREBBP a …
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.
Vlasevska S, Garcia-Ibanez L, Duval R, Holmes AB, Jahan R, Cai B, Kim A, Mo T, Basso K, Soni RK, Bhagat G, Dalla-Favera R, Pasqualucci L. Vlasevska S, et al. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218330120. doi: 10.1073/pnas.2218330120. Epub 2023 Mar 9. Proc Natl Acad Sci U S A. 2023. PMID: 36893259 Free PMC article.
Here, we show that combined germinal center (GC)-specific haploinsufficiency of Crebbp and Kmt2d synergizes in vivo to promote the expansion of abnormally polarized GCs, a common preneoplastic event. These enzymes form a biochemical complex on select enhancers/superenhance …
Here, we show that combined germinal center (GC)-specific haploinsufficiency of Crebbp and Kmt2d synergizes in vivo to promote the ex …
2,404 results