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Did you mean crisp[Title/Abstract] (1,323 results)?
Genome modification by CRISPR/Cas9.
Ma Y, Zhang L, Huang X. Ma Y, et al. FEBS J. 2014 Dec;281(23):5186-93. doi: 10.1111/febs.13110. Epub 2014 Nov 7. FEBS J. 2014. PMID: 25315507 Free article. Review.
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9-mediated genome modification enables us to edit the genomes of a variety of organisms rapidly and efficiently. ...We will also discuss the potential applications of …
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9-mediated genome modificati …
Delivering CRISPR: a review of the challenges and approaches.
Lino CA, Harper JC, Carney JP, Timlin JA. Lino CA, et al. Drug Deliv. 2018 Nov;25(1):1234-1257. doi: 10.1080/10717544.2018.1474964. Drug Deliv. 2018. PMID: 29801422 Free PMC article. Review.
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR-associated system, Cas), and its repurposing into a potent gene editing tool has revolutionized t …
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokary …
CRISPR/Cas9 for genome editing: progress, implications and challenges.
Zhang F, Wen Y, Guo X. Zhang F, et al. Hum Mol Genet. 2014 Sep 15;23(R1):R40-6. doi: 10.1093/hmg/ddu125. Epub 2014 Mar 20. Hum Mol Genet. 2014. PMID: 24651067 Review.
CRISPR/Cas9 comprises of a nonspecific Cas9 nuclease and a set of programmable sequence-specific CRISPR RNA (crRNA), which can guide Cas9 to cleave DNA and generate double-strand breaks at target sites. ...Here, we review the molecular mechanism, applications and ch
CRISPR/Cas9 comprises of a nonspecific Cas9 nuclease and a set of programmable sequence-specific CRISPR RNA (crRNA), which can
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications.
Liu C, Zhang L, Liu H, Cheng K. Liu C, et al. J Control Release. 2017 Nov 28;266:17-26. doi: 10.1016/j.jconrel.2017.09.012. Epub 2017 Sep 11. J Control Release. 2017. PMID: 28911805 Free PMC article. Review.
Since its discovery, CRISPR-Cas9 has become the most robust platform for genome engineering in eukaryotic cells. Recently, the CRISPR-Cas9 system has triggered enormous interest in therapeutic applications. CRISPR-Cas9 can be applied to correct disease-causin …
Since its discovery, CRISPR-Cas9 has become the most robust platform for genome engineering in eukaryotic cells. Recently, the CRI
The Biology of CRISPR-Cas: Backward and Forward.
Hille F, Richter H, Wong SP, Bratovič M, Ressel S, Charpentier E. Hille F, et al. Cell. 2018 Mar 8;172(6):1239-1259. doi: 10.1016/j.cell.2017.11.032. Cell. 2018. PMID: 29522745 Free article. Review.
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRI
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) protei …
Cancer CRISPR Screens In Vivo.
Chow RD, Chen S. Chow RD, et al. Trends Cancer. 2018 May;4(5):349-358. doi: 10.1016/j.trecan.2018.03.002. Epub 2018 Mar 30. Trends Cancer. 2018. PMID: 29709259 Free PMC article. Review.
Clustered regularly interspaced short palindromic repeats (CRISPR) screening is a powerful toolset for investigating diverse biological processes. ...This Opinion article discusses the current status of in vivo CRISPR screens in cancer and offers perspectives on fut …
Clustered regularly interspaced short palindromic repeats (CRISPR) screening is a powerful toolset for investigating diverse biologic …
Annotation and Classification of CRISPR-Cas Systems.
Makarova KS, Koonin EV. Makarova KS, et al. Methods Mol Biol. 2015;1311:47-75. doi: 10.1007/978-1-4939-2687-9_4. Methods Mol Biol. 2015. PMID: 25981466 Free PMC article. Review.
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is a prokaryotic adaptive immune system that is represented in most archaea and many bacteria. ...Comparative genomic analysis of the CRISPR-Cas systems in …
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is a prokaryotic adapt …
Different Methods of Delivering CRISPR/Cas9 Into Cells.
Chandrasekaran AP, Song M, Kim KS, Ramakrishna S. Chandrasekaran AP, et al. Prog Mol Biol Transl Sci. 2018;159:157-176. doi: 10.1016/bs.pmbts.2018.05.001. Epub 2018 Jun 12. Prog Mol Biol Transl Sci. 2018. PMID: 30340786 Review.
An RNA-dependent spacer is required for CRISPR/Cas9 to recognize the target DNA. Delivery of the CRISPR/Cas9-guide RNA (gRNA) complex to any cell results in modification of the target sequence. ...There are several methods available to deliver CRISPR/Cas9 and …
An RNA-dependent spacer is required for CRISPR/Cas9 to recognize the target DNA. Delivery of the CRISPR/Cas9-guide RNA (gRNA) …
CRISPR-Cas systems: ushering in the new genome editing era.
Perez Rojo F, Nyman RKM, Johnson AAT, Navarro MP, Ryan MH, Erskine W, Kaur P. Perez Rojo F, et al. Bioengineered. 2018;9(1):214-221. doi: 10.1080/21655979.2018.1470720. Bioengineered. 2018. PMID: 29968520 Free PMC article. Review.
This mini review summarizes the appearance of CRISPR-Cas systems with a focus on the predominant CRISPR-Cas9 system as well as the classifications and subtypes for CRISPR-Cas. Non-genome editing uses of CRISPR-Cas are also highlighted and a brief overv …
This mini review summarizes the appearance of CRISPR-Cas systems with a focus on the predominant CRISPR-Cas9 system as well as …
CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool.
Brokowski C, Adli M. Brokowski C, et al. J Mol Biol. 2019 Jan 4;431(1):88-101. doi: 10.1016/j.jmb.2018.05.044. Epub 2018 Jun 7. J Mol Biol. 2019. PMID: 29885329 Free PMC article. Review.
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occurs regularly. ...Here we review fundamental ethical issues including the following: 1) the extent to which CRISPR use should be perm …
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occ …
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