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2002 1
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2021 6807
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Genome modification by CRISPR/Cas9.
Ma Y, Zhang L, Huang X. Ma Y, et al. FEBS J. 2014 Dec;281(23):5186-93. doi: 10.1111/febs.13110. Epub 2014 Nov 7. FEBS J. 2014. PMID: 25315507 Free article. Review.
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9-mediated genome modification enables us to edit the genomes of a variety of organisms rapidly and efficiently. ...We will also discuss the potential applications of …
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9-mediated genome modificati …
CRISPR-Cas9 system: A new-fangled dawn in gene editing.
Gupta D, Bhattacharjee O, Mandal D, Sen MK, Dey D, Dasgupta A, Kazi TA, Gupta R, Sinharoy S, Acharya K, Chattopadhyay D, Ravichandiran V, Roy S, Ghosh D. Gupta D, et al. Life Sci. 2019 Sep 1;232:116636. doi: 10.1016/j.lfs.2019.116636. Epub 2019 Jul 8. Life Sci. 2019. PMID: 31295471 Review.
The off-target effects of CRISPR Cas system has been circumnavigated by using paired nickases. ...The execution of the CRISPR-Cas9 system has amplified the number of accessible scientific substitutes for studying gene function, thus enabling generation of CRISPR …
The off-target effects of CRISPR Cas system has been circumnavigated by using paired nickases. ...The execution of the CRISPR- …
CRISPR/Cas9 for genome editing: progress, implications and challenges.
Zhang F, Wen Y, Guo X. Zhang F, et al. Hum Mol Genet. 2014 Sep 15;23(R1):R40-6. doi: 10.1093/hmg/ddu125. Epub 2014 Mar 20. Hum Mol Genet. 2014. PMID: 24651067 Review.
CRISPR/Cas9 comprises of a nonspecific Cas9 nuclease and a set of programmable sequence-specific CRISPR RNA (crRNA), which can guide Cas9 to cleave DNA and generate double-strand breaks at target sites. ...Here, we review the molecular mechanism, applications and ch …
CRISPR/Cas9 comprises of a nonspecific Cas9 nuclease and a set of programmable sequence-specific CRISPR RNA (crRNA), which can …
Controlling and enhancing CRISPR systems.
Shivram H, Cress BF, Knott GJ, Doudna JA. Shivram H, et al. Nat Chem Biol. 2021 Jan;17(1):10-19. doi: 10.1038/s41589-020-00700-7. Epub 2020 Dec 16. Nat Chem Biol. 2021. PMID: 33328654 Free PMC article. Review.
Many bacterial and archaeal organisms use clustered regularly interspaced short palindromic repeats-CRISPR associated (CRISPR-Cas) systems to defend themselves from mobile genetic elements. ...To realize their full potential, it is important to control the timing, d …
Many bacterial and archaeal organisms use clustered regularly interspaced short palindromic repeats-CRISPR associated (CRISPR- …
Delivering CRISPR: a review of the challenges and approaches.
Lino CA, Harper JC, Carney JP, Timlin JA. Lino CA, et al. Drug Deliv. 2018 Nov;25(1):1234-1257. doi: 10.1080/10717544.2018.1474964. Drug Deliv. 2018. PMID: 29801422 Free PMC article. Review.
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR-associated system, Cas), and its repurposing into a potent gene editing tool has revolutionized t …
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokary …
CRISPR/Cas gene therapy.
Zhang B. Zhang B. J Cell Physiol. 2021 Apr;236(4):2459-2481. doi: 10.1002/jcp.30064. Epub 2020 Sep 22. J Cell Physiol. 2021. PMID: 32959897 Review.
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. ...As the quick modification of the CRISPR/Cas9 system, …
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated enzyme (Cas) is a naturally occurring gen …
The Biology of CRISPR-Cas: Backward and Forward.
Hille F, Richter H, Wong SP, Bratovič M, Ressel S, Charpentier E. Hille F, et al. Cell. 2018 Mar 8;172(6):1239-1259. doi: 10.1016/j.cell.2017.11.032. Cell. 2018. PMID: 29522745 Free article. Review.
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRI …
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) protei …
Various Aspects of a Gene Editing System-CRISPR-Cas9.
Janik E, Niemcewicz M, Ceremuga M, Krzowski L, Saluk-Bijak J, Bijak M. Janik E, et al. Int J Mol Sci. 2020 Dec 16;21(24):9604. doi: 10.3390/ijms21249604. Int J Mol Sci. 2020. PMID: 33339441 Free PMC article. Review.
The discovery of clustered, regularly interspaced short palindromic repeats (CRISPR) and their cooperation with CRISPR-associated (Cas) genes is one of the greatest advances of the century and has marked their application as a powerful genome engineering tool. ...In …
The discovery of clustered, regularly interspaced short palindromic repeats (CRISPR) and their cooperation with CRISPR-associa …
CRISPR-Cas bioinformatics.
Alkhnbashi OS, Meier T, Mitrofanov A, Backofen R, Voß B. Alkhnbashi OS, et al. Methods. 2020 Feb 1;172:3-11. doi: 10.1016/j.ymeth.2019.07.013. Epub 2019 Jul 19. Methods. 2020. PMID: 31326596 Review.
In recent years, the CRISPR-Cas system has also been engineered to facilitate target gene editing in eukaryotic genomes. Bioinformatics played an essential role in the detection and analysis of CRISPR systems and here we review the bioinformatics-based efforts that …
In recent years, the CRISPR-Cas system has also been engineered to facilitate target gene editing in eukaryotic genomes. Bioinformati …
Annotation and Classification of CRISPR-Cas Systems.
Makarova KS, Koonin EV. Makarova KS, et al. Methods Mol Biol. 2015;1311:47-75. doi: 10.1007/978-1-4939-2687-9_4. Methods Mol Biol. 2015. PMID: 25981466 Free PMC article. Review.
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is a prokaryotic adaptive immune system that is represented in most archaea and many bacteria. ...Comparative genomic analysis of the CRISPR-Cas systems in …
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is a prokaryotic adapt …
29,818 results
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