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Did you mean crisp[Title/Abstract] (1,323 results)?
Genome modification by CRISPR/Cas9.
Ma Y, Zhang L, Huang X. Ma Y, et al. FEBS J. 2014 Dec;281(23):5186-93. doi: 10.1111/febs.13110. Epub 2014 Nov 7. FEBS J. 2014. PMID: 25315507 Free article. Review.
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9-mediated genome modification enables us to edit the genomes of a variety of organisms rapidly and efficiently. ...We will also discuss the potential applications of …
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas)9-mediated genome modificati …
Delivering CRISPR: a review of the challenges and approaches.
Lino CA, Harper JC, Carney JP, Timlin JA. Lino CA, et al. Drug Deliv. 2018 Nov;25(1):1234-1257. doi: 10.1080/10717544.2018.1474964. Drug Deliv. 2018. PMID: 29801422 Free PMC article. Review.
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR-associated system, Cas), and its repurposing into a potent gene editing tool has revolutionized t …
Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokary …
CRISPR/Cas9 for genome editing: progress, implications and challenges.
Zhang F, Wen Y, Guo X. Zhang F, et al. Hum Mol Genet. 2014 Sep 15;23(R1):R40-6. doi: 10.1093/hmg/ddu125. Epub 2014 Mar 20. Hum Mol Genet. 2014. PMID: 24651067 Review.
CRISPR/Cas9 comprises of a nonspecific Cas9 nuclease and a set of programmable sequence-specific CRISPR RNA (crRNA), which can guide Cas9 to cleave DNA and generate double-strand breaks at target sites. ...Here, we review the molecular mechanism, applications and ch …
CRISPR/Cas9 comprises of a nonspecific Cas9 nuclease and a set of programmable sequence-specific CRISPR RNA (crRNA), which can …
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications.
Liu C, Zhang L, Liu H, Cheng K. Liu C, et al. J Control Release. 2017 Nov 28;266:17-26. doi: 10.1016/j.jconrel.2017.09.012. Epub 2017 Sep 11. J Control Release. 2017. PMID: 28911805 Free PMC article. Review.
Since its discovery, CRISPR-Cas9 has become the most robust platform for genome engineering in eukaryotic cells. Recently, the CRISPR-Cas9 system has triggered enormous interest in therapeutic applications. CRISPR-Cas9 can be applied to correct disease-causin …
Since its discovery, CRISPR-Cas9 has become the most robust platform for genome engineering in eukaryotic cells. Recently, the CRI …
The Biology of CRISPR-Cas: Backward and Forward.
Hille F, Richter H, Wong SP, Bratovič M, Ressel S, Charpentier E. Hille F, et al. Cell. 2018 Mar 8;172(6):1239-1259. doi: 10.1016/j.cell.2017.11.032. Cell. 2018. PMID: 29522745 Free article. Review.
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system against phages and other foreign genetic elements. Here, we review the biology of the diverse CRI …
In bacteria and archaea, clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) protei …
Cancer CRISPR Screens In Vivo.
Chow RD, Chen S. Chow RD, et al. Trends Cancer. 2018 May;4(5):349-358. doi: 10.1016/j.trecan.2018.03.002. Epub 2018 Mar 30. Trends Cancer. 2018. PMID: 29709259 Free PMC article. Review.
Clustered regularly interspaced short palindromic repeats (CRISPR) screening is a powerful toolset for investigating diverse biological processes. ...This Opinion article discusses the current status of in vivo CRISPR screens in cancer and offers perspectives on fut …
Clustered regularly interspaced short palindromic repeats (CRISPR) screening is a powerful toolset for investigating diverse biologic …
Annotation and Classification of CRISPR-Cas Systems.
Makarova KS, Koonin EV. Makarova KS, et al. Methods Mol Biol. 2015;1311:47-75. doi: 10.1007/978-1-4939-2687-9_4. Methods Mol Biol. 2015. PMID: 25981466 Free PMC article. Review.
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is a prokaryotic adaptive immune system that is represented in most archaea and many bacteria. ...Comparative genomic analysis of the CRISPR-Cas systems in …
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated proteins) is a prokaryotic adapt …
Different Methods of Delivering CRISPR/Cas9 Into Cells.
Chandrasekaran AP, Song M, Kim KS, Ramakrishna S. Chandrasekaran AP, et al. Prog Mol Biol Transl Sci. 2018;159:157-176. doi: 10.1016/bs.pmbts.2018.05.001. Epub 2018 Jun 12. Prog Mol Biol Transl Sci. 2018. PMID: 30340786 Review.
An RNA-dependent spacer is required for CRISPR/Cas9 to recognize the target DNA. Delivery of the CRISPR/Cas9-guide RNA (gRNA) complex to any cell results in modification of the target sequence. ...There are several methods available to deliver CRISPR/Cas9 and …
An RNA-dependent spacer is required for CRISPR/Cas9 to recognize the target DNA. Delivery of the CRISPR/Cas9-guide RNA (gRNA) …
CRISPR-Cas systems: ushering in the new genome editing era.
Perez Rojo F, Nyman RKM, Johnson AAT, Navarro MP, Ryan MH, Erskine W, Kaur P. Perez Rojo F, et al. Bioengineered. 2018;9(1):214-221. doi: 10.1080/21655979.2018.1470720. Bioengineered. 2018. PMID: 29968520 Free PMC article. Review.
This mini review summarizes the appearance of CRISPR-Cas systems with a focus on the predominant CRISPR-Cas9 system as well as the classifications and subtypes for CRISPR-Cas. Non-genome editing uses of CRISPR-Cas are also highlighted and a brief overv …
This mini review summarizes the appearance of CRISPR-Cas systems with a focus on the predominant CRISPR-Cas9 system as well as …
CRISPR Ethics: Moral Considerations for Applications of a Powerful Tool.
Brokowski C, Adli M. Brokowski C, et al. J Mol Biol. 2019 Jan 4;431(1):88-101. doi: 10.1016/j.jmb.2018.05.044. Epub 2018 Jun 7. J Mol Biol. 2019. PMID: 29885329 Free PMC article. Review.
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occurs regularly. ...Here we review fundamental ethical issues including the following: 1) the extent to which CRISPR use should be perm …
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is no longer an abstract hypothetical, but occ …
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