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Treatment of complex regional pain syndrome type I with bisphosphonates.
Giusti A, Bianchi G. Giusti A, et al. RMD Open. 2015 Aug 15;1(Suppl 1):e000056. doi: 10.1136/rmdopen-2015-000056. eCollection 2015. RMD Open. 2015. PMID: 26557377 Free PMC article. Review.
Complex regional pain syndrome type I (CRPS-I) is a common and disabling disorder affecting a peripheral limb, usually developing after a trauma to an extremity. ...Results of several clinical trials have suggested the potential beneficial effects of BPs in CRPS-I. …
Complex regional pain syndrome type I (CRPS-I) is a common and disabling disorder affecting a peripheral limb, usually developing aft …
Predictors of Responsiveness to Bisphosphonate Treatment in Patients with Complex Regional Pain Syndrome Type I: A Retrospective Chart Analysis.
Varenna M, Manara M, Rovelli F, Zucchi F, Sinigaglia L. Varenna M, et al. Pain Med. 2017 Jun 1;18(6):1131-1138. doi: 10.1093/pm/pnw207. Pain Med. 2017. PMID: 27651505
METHODS: This is a retrospective analysis of patients referred in the last five years to our rheumatologic tertiary care center, all fulfilling the Budapest CRPS-I diagnostic criteria and treated with three different bisphosphonate schedules (clodronate, pamidron …
METHODS: This is a retrospective analysis of patients referred in the last five years to our rheumatologic tertiary care center, all fulfill …
Efficacy and Safety of Bisphosphonates for Complex Regional Pain Syndrome : A Systematic Review and Meta-analysis.
Ferraro MC, O'Connell NE, Goebel A, Hill R, Curtis F, Wilkinson J, Center JR, Gustin SM, Cashin AG, McAuley JH. Ferraro MC, et al. Ann Intern Med. 2026 Feb;179(2):256-269. doi: 10.7326/ANNALS-25-03693. Epub 2025 Dec 16. Ann Intern Med. 2026. PMID: 41397259 Review.
DATA SYNTHESIS: Eleven trials (754 participants; CRPS type I, 97%), evaluating alendronate (n = 2), clodronate (n = 1), neridronate (n = 5), pamidronate (n = 1), and zoledronate (n = 2), were included. ...LIMITATIONS: High heterogeneity and uncertain medium- …
DATA SYNTHESIS: Eleven trials (754 participants; CRPS type I, 97%), evaluating alendronate (n = 2), clodronate (n = 1), neridronat …