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1990 1
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1999 32
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5,082 results

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Page 1
The structural basis for cohesin-CTCF-anchored loops.
Li Y, Haarhuis JHI, Sedeño Cacciatore Á, Oldenkamp R, van Ruiten MS, Willems L, Teunissen H, Muir KW, de Wit E, Rowland BD, Panne D. Li Y, et al. Nature. 2020 Feb;578(7795):472-476. doi: 10.1038/s41586-019-1910-z. Epub 2020 Jan 6. Nature. 2020. PMID: 31905366 Free PMC article.
Cohesin catalyses the folding of the genome into loops that are anchored by CTCF(1). The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. ...We demonstrate that this interaction is specifically required for CTCF-anchor …
Cohesin catalyses the folding of the genome into loops that are anchored by CTCF(1). The molecular mechanism of how cohesin and CT …
CTCF and CTCFL in cancer.
Debaugny RE, Skok JA. Debaugny RE, et al. Curr Opin Genet Dev. 2020 Apr;61:44-52. doi: 10.1016/j.gde.2020.02.021. Epub 2020 Apr 22. Curr Opin Genet Dev. 2020. PMID: 32334335 Free PMC article. Review.
CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), the paralog of CTCF, is normally transiently expressed in pre-meiotic male germ cells together with ubiquitously expressed …
CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF …
CTCF-mediated genome organization and leukemogenesis.
Qiu Y, Huang S. Qiu Y, et al. Leukemia. 2020 Sep;34(9):2295-2304. doi: 10.1038/s41375-020-0906-x. Epub 2020 Jun 9. Leukemia. 2020. PMID: 32518417 Free PMC article. Review.
Delineating theses normal and abnormal processes will evolve our understanding of disease pathogenesis and development of potential treatment strategies. This review highlights the role of CTCF and its associated protein complexes in three-dimensional genome organization i …
Delineating theses normal and abnormal processes will evolve our understanding of disease pathogenesis and development of potential treatmen …
Regulation of CTCF loop formation during pancreatic cell differentiation.
Lyu X, Rowley MJ, Kulik MJ, Dalton S, Corces VG. Lyu X, et al. Nat Commun. 2023 Oct 9;14(1):6314. doi: 10.1038/s41467-023-41964-6. Nat Commun. 2023. PMID: 37813869 Free PMC article.
We find that CTCF loops are formed and disassembled at different stages of the differentiation process by either recruitment of CTCF to new anchor sites or use of pre-existing sites not previously involved in loop formation. Recruitment of CTCF to new sites i …
We find that CTCF loops are formed and disassembled at different stages of the differentiation process by either recruitment of CT …
CTCF as a regulator of alternative splicing: new tricks for an old player.
Alharbi AB, Schmitz U, Bailey CG, Rasko JEJ. Alharbi AB, et al. Nucleic Acids Res. 2021 Aug 20;49(14):7825-7838. doi: 10.1093/nar/gkab520. Nucleic Acids Res. 2021. PMID: 34181707 Free PMC article. Review.
A new role for CTCF as a regulator of alternative splicing (AS) has now emerged. CTCF has been directly and indirectly linked to the modulation of AS at the individual transcript and at the transcriptome-wide level. ...In this review, we highlight previous discoveri …
A new role for CTCF as a regulator of alternative splicing (AS) has now emerged. CTCF has been directly and indirectly linked …
Roles of CTCF in conformation and functions of chromosome.
Liu F, Wu D, Wang X. Liu F, et al. Semin Cell Dev Biol. 2019 Jun;90:168-173. doi: 10.1016/j.semcdb.2018.07.021. Epub 2018 Jul 29. Semin Cell Dev Biol. 2019. PMID: 30031212 Review.
A large number of factors affect CTCF binding, methylation/demethylation, base mutation, or poly(adp-ribosyl)ation. CTCF is one of the most important elements in the regulation of chromatin folding by combining with CBSs in TADs in a positive-reverse or reverse-posi …
A large number of factors affect CTCF binding, methylation/demethylation, base mutation, or poly(adp-ribosyl)ation. CTCF is on …
CTCF: making the right connections.
Ghirlando R, Felsenfeld G. Ghirlando R, et al. Genes Dev. 2016 Apr 15;30(8):881-91. doi: 10.1101/gad.277863.116. Genes Dev. 2016. PMID: 27083996 Free PMC article. Review.
The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin complex, make physical contacts that create large loop domains. ...It now appears that …
The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites …
Multifaceted role of CTCF in X-chromosome inactivation.
Bammidi LS, Gayen S. Bammidi LS, et al. Chromosoma. 2024 Oct;133(4):217-231. doi: 10.1007/s00412-024-00826-w. Epub 2024 Oct 21. Chromosoma. 2024. PMID: 39433641 Review.
In general, CTCF is a well-known architectural protein, which plays an important role in chromatin organization and transcriptional regulation. Here, we provide significant insight into the role of CTCF in orchestrating X-chromosome inactivation and highlight future …
In general, CTCF is a well-known architectural protein, which plays an important role in chromatin organization and transcriptional r …
CTCF and BORIS in genome regulation and cancer.
Marshall AD, Bailey CG, Rasko JE. Marshall AD, et al. Curr Opin Genet Dev. 2014 Feb;24:8-15. doi: 10.1016/j.gde.2013.10.011. Epub 2013 Dec 14. Curr Opin Genet Dev. 2014. PMID: 24657531 Review.
CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in cancer. The tumour suppressor gene CTCF can be mutated or deleted in cancer, or CTCF DNA binding can be altered by epigenetic cha …
CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in can …
CTCF as a multifunctional protein in genome regulation and gene expression.
Kim S, Yu NK, Kaang BK. Kim S, et al. Exp Mol Med. 2015 Jun 5;47(6):e166. doi: 10.1038/emm.2015.33. Exp Mol Med. 2015. PMID: 26045254 Free PMC article. Review.
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. ...The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. ...
CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. ...The mapping of …
5,082 results